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• W2016231502 abstract "ABSTRACT The EcfG-type sigma factor RpoE2 is the regulator of the general stress response in Sinorhizobium meliloti . RpoE2 activity is negatively regulated by two NepR-type anti-sigma factors (RsiA1/A2), themselves under the control of two anti-anti-sigma factors (RsiB1/B2) belonging to the PhyR family of response regulators. The current model of RpoE2 activation suggests that in response to stress, RsiB1/B2 are activated by phosphorylation of an aspartate residue in their receiver domain. Once activated, RsiB1/B2 become able to interact with the anti-sigma factors and release RpoE2, which can then associate with the RNA polymerase to transcribe its target genes. The purpose of this work was to identify and characterize proteins involved in controlling the phosphorylation status of RsiB1/B2. Using in vivo approaches, we show that the putative histidine kinase encoded by the rsiC gene (SMc01507), located downstream from rpoE2 , is able to both positively and negatively regulate the general stress response. In addition, our data suggest that the negative action of RsiC results from inhibition of RsiB1/B2 phosphorylation. From these observations, we propose that RsiC is a bifunctional histidine kinase/phosphatase responsible for RsiB1/B2 phosphorylation or dephosphorylation in the presence or absence of stress, respectively. Two proteins were previously proposed to control PhyR phosphorylation in Caulobacter crescentus and Sphingomonas sp. strain FR1. However, these proteins contain a Pfam:HisKA_2 domain of dimerization and histidine phosphotransfer, whereas S. meliloti RsiC harbors a Pfam:HWE_HK domain instead. Therefore, this is the first report of an HWE_HK-containing protein controlling the general stress response in Alphaproteobacteria ." @default.
• W2016231502 created "2016-06-24" @default.
• W2016231502 creator A5033696182 @default.
• W2016231502 creator A5041325374 @default.
• W2016231502 date "2014-07-15" @default.
• W2016231502 modified "2023-09-30" @default.
• W2016231502 title "A Putative Bifunctional Histidine Kinase/Phosphatase of the HWE Family Exerts Positive and Negative Control on the Sinorhizobium meliloti General Stress Response" @default.
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• W2016231502 doi "https://doi.org/10.1128/jb.01623-14" @default.
• W2016231502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4097584" @default.
• W2016231502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24794560" @default.
• W2016231502 hasPublicationYear "2014" @default.
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