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• W2016232806 abstract "The TGF-β superfamily of growth and differentiation factors, including TGF-β, Activins and bone morphogenetic proteins (BMPs) play critical roles in regulating the development of many organisms. These factors signal through a heteromeric complex of type I and II serine/threonine kinase receptors that phosphorylate members of the Smad family of transcription factors, thereby promoting their nuclear localization. Although components of TGF-β/Activin signaling pathways are well defined in vertebrates, no such pathway has been clearly defined in invertebrates. In this study we describe the role of Baboon (Babo), a type I Activin receptor previously called Atr-I, in Drosophila development and characterize aspects of the Babo intracellular signal-transduction pathway. Genetic analysis of babo loss-of-function mutants and ectopic activation studies indicate that Babo signaling plays a role in regulating cell proliferation. In mammalian cells, activated Babo specifically stimulates Smad2-dependent pathways to induce TGF-β/Activin-responsive promoters but not BMP-responsive elements. Furthermore, we identify a new Drosophila Smad, termed dSmad2, that is most closely related to vertebrate Smads 2 and 3. Activated Babo associates with dSmad2 but not Mad, phosphorylates the carboxy-terminal SSXS motif and induces heteromeric complex formation with Medea, the Drosophila Smad4 homolog. Our results define a novel Drosophila Activin/TGF-β pathway that is analogous to its vertebrate counterpart and show that this pathway functions to promote cellular growth with minimal effects on patterning." @default.
• W2016232806 created "2016-06-24" @default.
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• W2016232806 date "1999-01-01" @default.
• W2016232806 modified "2023-09-25" @default.
• W2016232806 title "The <i>Drosophila</i> Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development" @default.
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• W2016232806 doi "https://doi.org/10.1101/gad.13.1.98" @default.
• W2016232806 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316373" @default.
• W2016232806 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9887103" @default.
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