FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016235063> ?p ?o ?g. }

• W2016235063 endingPage "3453" @default.
• W2016235063 startingPage "3447" @default.
• W2016235063 abstract "Superparamagnetic iron-oxide nanoparticles are useful as contrast agents for anatomical, functional and cellular MRI, drug delivery agents, and diagnostic biosensors. Nanoparticles are generally cleared by the reticuloendothelial system (RES), in particular taken up by Kupffer cells in the liver, limiting particle bioavailability and in-vivo applications. Strategies that decrease the RES clearance and prolong the circulation residence time of particles can improve the in-vivo targeting efficiency.Intralipid 20.0%, an FDA approved nutritional supplement, was intravenously administered in rats at the clinical dose (2g/kg) 1h before intravenous injection of ultra-small superparamagnetic iron-oxide (USPIO) or micron-sized paramagnetic iron-oxide (MPIO) particles. Blood half-life, monocyte labeling efficiency, and particle biodistribution were assessed by magnetic resonance relaxometry, flow cytometry, inductively-coupled plasma MS, and histology.Pre-treatment with Intralipid resulted in a 3.1-fold increase in USPIO blood half-life and a 2-fold increase in USPIO-labeled monocytes. A 2.5-fold increase in MPIO blood half-life and a 5-fold increase in MPIO-labeled monocytes were observed following Intralipid pre-treatment, with a 3.2-fold increase in mean iron content up to 2.60pg Fe/monocyte. With Intralipid, there was a 49.2% and 45.1% reduction in liver uptake vs. untreated controls at 48h for USPIO and MPIO, respectively.Intralipid pre-treatment significantly decreases initial RES uptake and increases in-vivo circulation and blood monocyte labeling efficiency for nano- and micron-sized superparamagnetic iron-oxide particles.Our findings can have broad applications for imaging and drug delivery applications, increasing the bioavailability of nano- and micron-sized particles for target sites other than the liver." @default.
• W2016235063 created "2016-06-24" @default.
• W2016235063 creator A5003190501 @default.
• W2016235063 creator A5009400572 @default.
• W2016235063 creator A5012299627 @default.
• W2016235063 creator A5018999020 @default.
• W2016235063 creator A5022501599 @default.
• W2016235063 creator A5054832727 @default.
• W2016235063 creator A5075307449 @default.
• W2016235063 creator A5077227967 @default.
• W2016235063 creator A5080178867 @default.
• W2016235063 creator A5086565038 @default.
• W2016235063 creator A5091066140 @default.
• W2016235063 date "2013-06-01" @default.
• W2016235063 modified "2023-10-12" @default.
• W2016235063 title "Decreased reticuloendothelial system clearance and increased blood half-life and immune cell labeling for nano- and micron-sized superparamagnetic iron-oxide particles upon pre-treatment with Intralipid" @default.
• W2016235063 cites W120534517 @default.
• W2016235063 cites W1705921322 @default.
• W2016235063 cites W1757677204 @default.
• W2016235063 cites W1953299746 @default.
• W2016235063 cites W1966963585 @default.
• W2016235063 cites W1967637067 @default.
• W2016235063 cites W1968484150 @default.
• W2016235063 cites W1968909035 @default.
• W2016235063 cites W1975359123 @default.
• W2016235063 cites W1979716619 @default.
• W2016235063 cites W1984421760 @default.
• W2016235063 cites W1989065176 @default.
• W2016235063 cites W1991183903 @default.
• W2016235063 cites W1991379144 @default.
• W2016235063 cites W2004083062 @default.
• W2016235063 cites W2015371492 @default.
• W2016235063 cites W2021345126 @default.
• W2016235063 cites W2023137223 @default.
• W2016235063 cites W2023890923 @default.
• W2016235063 cites W2029179588 @default.
• W2016235063 cites W2031178652 @default.
• W2016235063 cites W2031565650 @default.
• W2016235063 cites W2041004691 @default.
• W2016235063 cites W2045226800 @default.
• W2016235063 cites W2047855476 @default.
• W2016235063 cites W2053311966 @default.
• W2016235063 cites W2062993966 @default.
• W2016235063 cites W2065527895 @default.
• W2016235063 cites W2069676654 @default.
• W2016235063 cites W2069928673 @default.
• W2016235063 cites W2082769422 @default.
• W2016235063 cites W2083568292 @default.
• W2016235063 cites W2093975421 @default.
• W2016235063 cites W2097204745 @default.
• W2016235063 cites W2099193754 @default.
• W2016235063 cites W2100601291 @default.
• W2016235063 cites W2106147359 @default.
• W2016235063 cites W2107370389 @default.
• W2016235063 cites W2107525560 @default.
• W2016235063 cites W2113136548 @default.
• W2016235063 cites W2115057777 @default.
• W2016235063 cites W2119678257 @default.
• W2016235063 cites W2120668470 @default.
• W2016235063 cites W2125390543 @default.
• W2016235063 cites W2134231135 @default.
• W2016235063 cites W2138968683 @default.
• W2016235063 cites W2140181820 @default.
• W2016235063 cites W2141722219 @default.
• W2016235063 cites W2160843021 @default.
• W2016235063 cites W2182949166 @default.
• W2016235063 cites W2276706217 @default.
• W2016235063 cites W2323782004 @default.
• W2016235063 doi "https://doi.org/10.1016/j.bbagen.2013.01.021" @default.
• W2016235063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3640706" @default.
• W2016235063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23396002" @default.
• W2016235063 hasPublicationYear "2013" @default.
• W2016235063 type Work @default.
• W2016235063 sameAs 2016235063 @default.
• W2016235063 citedByCount "61" @default.
• W2016235063 countsByYear W20162350632014 @default.
• W2016235063 countsByYear W20162350632015 @default.
• W2016235063 countsByYear W20162350632016 @default.
• W2016235063 countsByYear W20162350632017 @default.
• W2016235063 countsByYear W20162350632018 @default.
• W2016235063 countsByYear W20162350632019 @default.
• W2016235063 countsByYear W20162350632020 @default.
• W2016235063 countsByYear W20162350632021 @default.
• W2016235063 countsByYear W20162350632022 @default.
• W2016235063 countsByYear W20162350632023 @default.
• W2016235063 crossrefType "journal-article" @default.
• W2016235063 hasAuthorship W2016235063A5003190501 @default.
• W2016235063 hasAuthorship W2016235063A5009400572 @default.
• W2016235063 hasAuthorship W2016235063A5012299627 @default.
• W2016235063 hasAuthorship W2016235063A5018999020 @default.
• W2016235063 hasAuthorship W2016235063A5022501599 @default.
• W2016235063 hasAuthorship W2016235063A5054832727 @default.
• W2016235063 hasAuthorship W2016235063A5075307449 @default.
• W2016235063 hasAuthorship W2016235063A5077227967 @default.
• W2016235063 hasAuthorship W2016235063A5080178867 @default.
• W2016235063 hasAuthorship W2016235063A5086565038 @default.
• W2016235063 hasAuthorship W2016235063A5091066140 @default.
• W2016235063 hasBestOaLocation W20162350632 @default.

• next