FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016239180> ?p ?o ?g. }

• W2016239180 endingPage "832" @default.
• W2016239180 startingPage "824" @default.
• W2016239180 abstract "Endomorphin 1 (EM-1) and endomorphin 2 (EM-2) were tested for their capacity to alter immune function. Addition of either of these peptides to murine spleen cells in vitro inhibited antibody formation to sheep red blood cells in a bi-phasic dose dependent manner. Maximal inhibition was achieved at doses in the range of 10(-13) to 10(-15)M. Neither naloxone (general opioid receptor antagonist) nor CTAP (selective mu opioid receptor antagonist) blocked the immunosuppressive effect. To show that there was specificity to the immunosuppressive activity of the peptides, affinity-purified rabbit antibodies were raised against each of the synthetic EM peptides haptenized to KLH and tested for capacity to inhibit immunosuppression. Antibody responses were monitored by a standard solid phase antibody capture ELISA, and antibodies were purified by immunochromatography using the synthetic peptides coupled to a Sepharose 6B resin. Verification of the specificity of affinity-purified antisera was performed by immunodot-blot and solid-phase RIA assays. The antisera specific for both EM-1 and EM-2 neutralized the immunosuppressive effects of their respective peptides in a dose-related manner. Control normal rabbit IgG had no blocking activity on either EM-1 or EM-2. These studies show that the endomorphins are immunomodulatory at ultra-low concentrations, but the data do not support a mechanism involving the mu-opioid receptor." @default.
• W2016239180 created "2016-06-24" @default.
• W2016239180 creator A5008766246 @default.
• W2016239180 creator A5010204930 @default.
• W2016239180 creator A5016366494 @default.
• W2016239180 creator A5052550871 @default.
• W2016239180 creator A5054710841 @default.
• W2016239180 creator A5054800487 @default.
• W2016239180 creator A5064198617 @default.
• W2016239180 creator A5067003063 @default.
• W2016239180 creator A5077020787 @default.
• W2016239180 creator A5083366854 @default.
• W2016239180 creator A5084801324 @default.
• W2016239180 creator A5090773805 @default.
• W2016239180 date "2008-08-01" @default.
• W2016239180 modified "2023-09-27" @default.
• W2016239180 title "Endomorphin 1 and endomorphin 2 suppress in vitro antibody formation at ultra-low concentrations: Anti-peptide antibodies but not opioid antagonists block the activity" @default.
• W2016239180 cites W1965494788 @default.
• W2016239180 cites W1965572881 @default.
• W2016239180 cites W1966022227 @default.
• W2016239180 cites W1969646859 @default.
• W2016239180 cites W1969845682 @default.
• W2016239180 cites W1973068053 @default.
• W2016239180 cites W1975262853 @default.
• W2016239180 cites W1975649472 @default.
• W2016239180 cites W1986727340 @default.
• W2016239180 cites W1986751279 @default.
• W2016239180 cites W1986825833 @default.
• W2016239180 cites W1996804028 @default.
• W2016239180 cites W1999451543 @default.
• W2016239180 cites W2001238760 @default.
• W2016239180 cites W2003747800 @default.
• W2016239180 cites W2003829627 @default.
• W2016239180 cites W2007149931 @default.
• W2016239180 cites W2010065648 @default.
• W2016239180 cites W2011973300 @default.
• W2016239180 cites W2021233566 @default.
• W2016239180 cites W2023551439 @default.
• W2016239180 cites W2025788872 @default.
• W2016239180 cites W2032816274 @default.
• W2016239180 cites W2038278262 @default.
• W2016239180 cites W2039245564 @default.
• W2016239180 cites W2043364141 @default.
• W2016239180 cites W2045394078 @default.
• W2016239180 cites W2046181541 @default.
• W2016239180 cites W2048886131 @default.
• W2016239180 cites W2050716453 @default.
• W2016239180 cites W2056282259 @default.
• W2016239180 cites W2059302025 @default.
• W2016239180 cites W2071481472 @default.
• W2016239180 cites W2072971490 @default.
• W2016239180 cites W2076466501 @default.
• W2016239180 cites W2080447652 @default.
• W2016239180 cites W2083411648 @default.
• W2016239180 cites W2085986158 @default.
• W2016239180 cites W2092144004 @default.
• W2016239180 cites W2093110345 @default.
• W2016239180 cites W2093912831 @default.
• W2016239180 cites W2117854425 @default.
• W2016239180 cites W2120628922 @default.
• W2016239180 cites W2122534380 @default.
• W2016239180 cites W2126792672 @default.
• W2016239180 cites W2133510368 @default.
• W2016239180 cites W2136046736 @default.
• W2016239180 cites W2137964312 @default.
• W2016239180 cites W2147815294 @default.
• W2016239180 cites W2158512964 @default.
• W2016239180 cites W2166622535 @default.
• W2016239180 cites W2313193534 @default.
• W2016239180 cites W307835833 @default.
• W2016239180 doi "https://doi.org/10.1016/j.bbi.2008.02.004" @default.
• W2016239180 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3926125" @default.
• W2016239180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18374539" @default.
• W2016239180 hasPublicationYear "2008" @default.
• W2016239180 type Work @default.
• W2016239180 sameAs 2016239180 @default.
• W2016239180 citedByCount "12" @default.
• W2016239180 countsByYear W20162391802014 @default.
• W2016239180 countsByYear W20162391802017 @default.
• W2016239180 countsByYear W20162391802023 @default.
• W2016239180 crossrefType "journal-article" @default.
• W2016239180 hasAuthorship W2016239180A5008766246 @default.
• W2016239180 hasAuthorship W2016239180A5010204930 @default.
• W2016239180 hasAuthorship W2016239180A5016366494 @default.
• W2016239180 hasAuthorship W2016239180A5052550871 @default.
• W2016239180 hasAuthorship W2016239180A5054710841 @default.
• W2016239180 hasAuthorship W2016239180A5054800487 @default.
• W2016239180 hasAuthorship W2016239180A5064198617 @default.
• W2016239180 hasAuthorship W2016239180A5067003063 @default.
• W2016239180 hasAuthorship W2016239180A5077020787 @default.
• W2016239180 hasAuthorship W2016239180A5083366854 @default.
• W2016239180 hasAuthorship W2016239180A5084801324 @default.
• W2016239180 hasAuthorship W2016239180A5090773805 @default.
• W2016239180 hasBestOaLocation W20162391802 @default.
• W2016239180 hasConcept C104317684 @default.
• W2016239180 hasConcept C153911025 @default.
• W2016239180 hasConcept C159654299 @default.
• W2016239180 hasConcept C170493617 @default.

• next