FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016239192> ?p ?o ?g. }

• W2016239192 endingPage "630" @default.
• W2016239192 startingPage "617" @default.
• W2016239192 abstract "A long-term system of organ culture for bovine lenses was used to investigate the effect of osmotic stress on lens opacification and crystallin loss. Lenses were pre-incubated in control medium containing l-[U-14C]tyrosine so that labelled crystallins were produced. The fate of these crystallins was studied in relation to two forms of osmotic stress. The addition of either ouabain or EGTA to the medium induced severe osmotic swelling and disturbance of the lens monovalent cation balance, but only the former treatment was followed by an increase in lens calcium. The changes due to osmotic stress were accompanied by loss of transparency and protein only in the lenses with increased calcium. Both opacification and increased calcium were found largely to be confined to the outer cortical fibres. Protein loss increased with time as lens calcium continued to increase. The protein recovered from the incubation medium was characterized by gel filtration and immunological techniques. The first protein detected was βl-crystallin, and this formed the major part of the lost protein throughout, although α- and γ- crystallins were detected at a later stage. Increased calcium also resulted in a change in the susceptibility of the crystallins to aggregation, since there was an increase in [14C]tyrosine incorporated into the lens high-molecular-weight (HM) fraction after exposure to ouabain, but not after exposure to EGTA. The relevance of these findings to human cataract is discussed." @default.
• W2016239192 created "2016-06-24" @default.
• W2016239192 creator A5044785988 @default.
• W2016239192 creator A5046252066 @default.
• W2016239192 creator A5061455039 @default.
• W2016239192 date "1986-06-01" @default.
• W2016239192 modified "2023-10-10" @default.
• W2016239192 title "Calcium-induced opacification and loss of protein in the organ-cultured bovine lens" @default.
• W2016239192 cites W1775749144 @default.
• W2016239192 cites W1965472751 @default.
• W2016239192 cites W1968492568 @default.
• W2016239192 cites W1969731157 @default.
• W2016239192 cites W1972313209 @default.
• W2016239192 cites W1976713241 @default.
• W2016239192 cites W1977262893 @default.
• W2016239192 cites W1987445204 @default.
• W2016239192 cites W1988581719 @default.
• W2016239192 cites W1988720723 @default.
• W2016239192 cites W1992519772 @default.
• W2016239192 cites W1994984571 @default.
• W2016239192 cites W1999888020 @default.
• W2016239192 cites W2007293727 @default.
• W2016239192 cites W2007854058 @default.
• W2016239192 cites W2013872219 @default.
• W2016239192 cites W2018377262 @default.
• W2016239192 cites W2026724376 @default.
• W2016239192 cites W2032929246 @default.
• W2016239192 cites W2036388116 @default.
• W2016239192 cites W2040268687 @default.
• W2016239192 cites W2040492192 @default.
• W2016239192 cites W2050087590 @default.
• W2016239192 cites W2055357754 @default.
• W2016239192 cites W2055902473 @default.
• W2016239192 cites W2058837235 @default.
• W2016239192 cites W2070762010 @default.
• W2016239192 cites W2075552513 @default.
• W2016239192 cites W2083955842 @default.
• W2016239192 cites W2086217342 @default.
• W2016239192 cites W2120783213 @default.
• W2016239192 cites W2123929920 @default.
• W2016239192 cites W2168793594 @default.
• W2016239192 cites W2404400472 @default.
• W2016239192 cites W2410789929 @default.
• W2016239192 cites W3049438204 @default.
• W2016239192 doi "https://doi.org/10.1016/0014-4835(86)90051-5" @default.
• W2016239192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3087764" @default.
• W2016239192 hasPublicationYear "1986" @default.
• W2016239192 type Work @default.
• W2016239192 sameAs 2016239192 @default.
• W2016239192 citedByCount "48" @default.
• W2016239192 countsByYear W20162391922015 @default.
• W2016239192 countsByYear W20162391922016 @default.
• W2016239192 countsByYear W20162391922017 @default.
• W2016239192 countsByYear W20162391922018 @default.
• W2016239192 crossrefType "journal-article" @default.
• W2016239192 hasAuthorship W2016239192A5044785988 @default.
• W2016239192 hasAuthorship W2016239192A5046252066 @default.
• W2016239192 hasAuthorship W2016239192A5061455039 @default.
• W2016239192 hasConcept C104317684 @default.
• W2016239192 hasConcept C12554922 @default.
• W2016239192 hasConcept C151730666 @default.
• W2016239192 hasConcept C15336307 @default.
• W2016239192 hasConcept C168529131 @default.
• W2016239192 hasConcept C178790620 @default.
• W2016239192 hasConcept C185592680 @default.
• W2016239192 hasConcept C202751555 @default.
• W2016239192 hasConcept C25642318 @default.
• W2016239192 hasConcept C2776165026 @default.
• W2016239192 hasConcept C2777658833 @default.
• W2016239192 hasConcept C2779133857 @default.
• W2016239192 hasConcept C28483552 @default.
• W2016239192 hasConcept C519063684 @default.
• W2016239192 hasConcept C537181965 @default.
• W2016239192 hasConcept C55493867 @default.
• W2016239192 hasConcept C7263354 @default.
• W2016239192 hasConcept C86803240 @default.
• W2016239192 hasConceptScore W2016239192C104317684 @default.
• W2016239192 hasConceptScore W2016239192C12554922 @default.
• W2016239192 hasConceptScore W2016239192C151730666 @default.
• W2016239192 hasConceptScore W2016239192C15336307 @default.
• W2016239192 hasConceptScore W2016239192C168529131 @default.
• W2016239192 hasConceptScore W2016239192C178790620 @default.
• W2016239192 hasConceptScore W2016239192C185592680 @default.
• W2016239192 hasConceptScore W2016239192C202751555 @default.
• W2016239192 hasConceptScore W2016239192C25642318 @default.
• W2016239192 hasConceptScore W2016239192C2776165026 @default.
• W2016239192 hasConceptScore W2016239192C2777658833 @default.
• W2016239192 hasConceptScore W2016239192C2779133857 @default.
• W2016239192 hasConceptScore W2016239192C28483552 @default.
• W2016239192 hasConceptScore W2016239192C519063684 @default.
• W2016239192 hasConceptScore W2016239192C537181965 @default.
• W2016239192 hasConceptScore W2016239192C55493867 @default.
• W2016239192 hasConceptScore W2016239192C7263354 @default.
• W2016239192 hasConceptScore W2016239192C86803240 @default.
• W2016239192 hasIssue "6" @default.
• W2016239192 hasLocation W20162391921 @default.
• W2016239192 hasLocation W20162391922 @default.
• W2016239192 hasOpenAccess W2016239192 @default.

• next