FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016243066> ?p ?o ?g. }

• W2016243066 endingPage "1176" @default.
• W2016243066 startingPage "1168" @default.
• W2016243066 abstract "Stereotactic body radiation therapy (SBRT) in central lung tumors has been associated with higher rates of severe toxicity. We sought to evaluate toxicity and local control in a large cohort and to identify predictive dosimetric parameters.We identified patients who received SBRT for central tumors according to either of 2 definitions. Local failure (LF) was estimated using a competing risks model, and multivariate analysis (MVA) was used to assess factors associated with LF. We reviewed patient toxicity and applied Cox proportional hazard analysis and log-rank tests to assess whether dose-volume metrics of normal structures correlated with pulmonary toxicity.One hundred twenty-five patients received SBRT for non-small cell lung cancer (n=103) or metastatic lesions (n=22), using intensity modulated radiation therapy. The most common dose was 45 Gy in 5 fractions. Median follow-up was 17.4 months. Incidence of toxicity ≥ grade 3 was 8.0%, including 5.6% pulmonary toxicity. Sixteen patients (12.8%) experienced esophageal toxicity ≥ grade 2, including 50% of patients in whom PTV overlapped the esophagus. There were 2 treatment-related deaths. Among patients receiving biologically effective dose (BED) ≥80 Gy (n=108), 2-year LF was 21%. On MVA, gross tumor volume (GTV) was significantly associated with LF. None of the studied dose-volume metrics of the lungs, heart, proximal bronchial tree (PBT), or 2 cm expansion of the PBT (no-fly-zone [NFZ]) correlated with pulmonary toxicity ≥grade 2. There were no differences in pulmonary toxicity between central tumors located inside the NFZ and those outside the NFZ but with planning target volume (PTV) intersecting the mediastinum.Using moderate doses, SBRT for central lung tumors achieves acceptable local control with low rates of severe toxicity. Dosimetric analysis showed no significant correlation between dose to the lungs, heart, or NFZ and severe pulmonary toxicity. Esophageal toxicity may be an underappreciated risk, particularly when PTV overlaps the esophagus." @default.
• W2016243066 created "2016-06-24" @default.
• W2016243066 creator A5003258247 @default.
• W2016243066 creator A5008379872 @default.
• W2016243066 creator A5010688246 @default.
• W2016243066 creator A5022293657 @default.
• W2016243066 creator A5026192010 @default.
• W2016243066 creator A5034787589 @default.
• W2016243066 creator A5045550469 @default.
• W2016243066 creator A5052930984 @default.
• W2016243066 creator A5065864037 @default.
• W2016243066 creator A5081575876 @default.
• W2016243066 date "2014-12-01" @default.
• W2016243066 modified "2023-09-26" @default.
• W2016243066 title "Local Control and Toxicity in a Large Cohort of Central Lung Tumors Treated With Stereotactic Body Radiation Therapy" @default.
• W2016243066 cites W1972037710 @default.
• W2016243066 cites W1981905971 @default.
• W2016243066 cites W1985876222 @default.
• W2016243066 cites W2013058506 @default.
• W2016243066 cites W2024121508 @default.
• W2016243066 cites W2031236516 @default.
• W2016243066 cites W2041602527 @default.
• W2016243066 cites W2046757928 @default.
• W2016243066 cites W2051021899 @default.
• W2016243066 cites W2060653243 @default.
• W2016243066 cites W2061893665 @default.
• W2016243066 cites W2063739307 @default.
• W2016243066 cites W2069787198 @default.
• W2016243066 cites W2071364157 @default.
• W2016243066 cites W2077096883 @default.
• W2016243066 cites W2088901883 @default.
• W2016243066 cites W2108569878 @default.
• W2016243066 cites W2115646671 @default.
• W2016243066 cites W2119975047 @default.
• W2016243066 cites W2127426304 @default.
• W2016243066 cites W2128366510 @default.
• W2016243066 cites W2143022948 @default.
• W2016243066 cites W2144644621 @default.
• W2016243066 cites W2159746573 @default.
• W2016243066 cites W2806575069 @default.
• W2016243066 doi "https://doi.org/10.1016/j.ijrobp.2014.08.008" @default.
• W2016243066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4276458" @default.
• W2016243066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25303891" @default.
• W2016243066 hasPublicationYear "2014" @default.
• W2016243066 type Work @default.
• W2016243066 sameAs 2016243066 @default.
• W2016243066 citedByCount "88" @default.
• W2016243066 countsByYear W20162430662015 @default.
• W2016243066 countsByYear W20162430662016 @default.
• W2016243066 countsByYear W20162430662017 @default.
• W2016243066 countsByYear W20162430662018 @default.
• W2016243066 countsByYear W20162430662019 @default.
• W2016243066 countsByYear W20162430662020 @default.
• W2016243066 countsByYear W20162430662021 @default.
• W2016243066 countsByYear W20162430662022 @default.
• W2016243066 countsByYear W20162430662023 @default.
• W2016243066 crossrefType "journal-article" @default.
• W2016243066 hasAuthorship W2016243066A5003258247 @default.
• W2016243066 hasAuthorship W2016243066A5008379872 @default.
• W2016243066 hasAuthorship W2016243066A5010688246 @default.
• W2016243066 hasAuthorship W2016243066A5022293657 @default.
• W2016243066 hasAuthorship W2016243066A5026192010 @default.
• W2016243066 hasAuthorship W2016243066A5034787589 @default.
• W2016243066 hasAuthorship W2016243066A5045550469 @default.
• W2016243066 hasAuthorship W2016243066A5052930984 @default.
• W2016243066 hasAuthorship W2016243066A5065864037 @default.
• W2016243066 hasAuthorship W2016243066A5081575876 @default.
• W2016243066 hasBestOaLocation W20162430662 @default.
• W2016243066 hasConcept C126322002 @default.
• W2016243066 hasConcept C126838900 @default.
• W2016243066 hasConcept C141071460 @default.
• W2016243066 hasConcept C2776256026 @default.
• W2016243066 hasConcept C2777714996 @default.
• W2016243066 hasConcept C2780387249 @default.
• W2016243066 hasConcept C2781047374 @default.
• W2016243066 hasConcept C29730261 @default.
• W2016243066 hasConcept C2989005 @default.
• W2016243066 hasConcept C509974204 @default.
• W2016243066 hasConcept C71924100 @default.
• W2016243066 hasConcept C72563966 @default.
• W2016243066 hasConceptScore W2016243066C126322002 @default.
• W2016243066 hasConceptScore W2016243066C126838900 @default.
• W2016243066 hasConceptScore W2016243066C141071460 @default.
• W2016243066 hasConceptScore W2016243066C2776256026 @default.
• W2016243066 hasConceptScore W2016243066C2777714996 @default.
• W2016243066 hasConceptScore W2016243066C2780387249 @default.
• W2016243066 hasConceptScore W2016243066C2781047374 @default.
• W2016243066 hasConceptScore W2016243066C29730261 @default.
• W2016243066 hasConceptScore W2016243066C2989005 @default.
• W2016243066 hasConceptScore W2016243066C509974204 @default.
• W2016243066 hasConceptScore W2016243066C71924100 @default.
• W2016243066 hasConceptScore W2016243066C72563966 @default.
• W2016243066 hasIssue "5" @default.
• W2016243066 hasLocation W20162430661 @default.
• W2016243066 hasLocation W20162430662 @default.
• W2016243066 hasLocation W20162430663 @default.
• W2016243066 hasLocation W20162430664 @default.
• W2016243066 hasOpenAccess W2016243066 @default.

• next