Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016243384> ?p ?o ?g. }
- W2016243384 endingPage "111" @default.
- W2016243384 startingPage "106" @default.
- W2016243384 abstract "Diazoxide is the prototypical opener of mitochondrial ATP-sensitive potassium channels (mitoKATP) and protects neurons in vivo and in vitro against chemical and anoxic stresses. While we have previously shown that diazoxide administration induces acute preconditioning against transient cerebral ischemia in rats, the potential for delayed preconditioning of diazoxide has not been examined. The purpose of this study was to determine whether diazoxide promotes delayed preconditioning following 90 min of middle cerebral artery occlusion (MCAO) in male Wistar rats. Diazoxide (10 mg/kg) or vehicle was injected intraperitoneally 24 h before MCAO. Infarct volumes were measured 72 h after reperfusion. In animals anesthetized with halothane, treatment with diazoxide exhibited a 35% reduction (48.3 ± 3.0% to 31.3 ± 4.8%) and 18% reduction (35.1 ± 2.2% to 28.9 ± 2.1%) in cortical and subcortical infarct volumes, respectively. Administration of the mitoKATP blocker 5-hydroxydecanoate attenuated this beneficial effect. In contrast, diazoxide did not induce delayed preconditioning in isoflurane-anesthetized rats. These findings support the concept that diazoxide produces delayed preconditioning via mitoKATP activation but that physiological status can affect induction of preconditioning." @default.
- W2016243384 created "2016-06-24" @default.
- W2016243384 creator A5020289992 @default.
- W2016243384 creator A5036118230 @default.
- W2016243384 creator A5040836134 @default.
- W2016243384 creator A5072838750 @default.
- W2016243384 date "2007-09-01" @default.
- W2016243384 modified "2023-10-15" @default.
- W2016243384 title "Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats" @default.
- W2016243384 cites W1551955865 @default.
- W2016243384 cites W1937991361 @default.
- W2016243384 cites W1973126805 @default.
- W2016243384 cites W1981653972 @default.
- W2016243384 cites W1983558383 @default.
- W2016243384 cites W1985243477 @default.
- W2016243384 cites W1988086690 @default.
- W2016243384 cites W1999631310 @default.
- W2016243384 cites W2005918419 @default.
- W2016243384 cites W2013900800 @default.
- W2016243384 cites W2018977754 @default.
- W2016243384 cites W2020147370 @default.
- W2016243384 cites W2027310465 @default.
- W2016243384 cites W2046297960 @default.
- W2016243384 cites W2046354381 @default.
- W2016243384 cites W2049410223 @default.
- W2016243384 cites W2060797779 @default.
- W2016243384 cites W2061138920 @default.
- W2016243384 cites W2064688638 @default.
- W2016243384 cites W2073248216 @default.
- W2016243384 cites W2077549773 @default.
- W2016243384 cites W2082329504 @default.
- W2016243384 cites W2082425573 @default.
- W2016243384 cites W2082782176 @default.
- W2016243384 cites W2095329663 @default.
- W2016243384 cites W2095984188 @default.
- W2016243384 cites W2096442918 @default.
- W2016243384 cites W2106829353 @default.
- W2016243384 cites W2110204147 @default.
- W2016243384 cites W2112505121 @default.
- W2016243384 cites W2113208711 @default.
- W2016243384 cites W2126544267 @default.
- W2016243384 cites W2136545895 @default.
- W2016243384 cites W2147022890 @default.
- W2016243384 cites W2156651751 @default.
- W2016243384 cites W2169160949 @default.
- W2016243384 cites W2171387787 @default.
- W2016243384 cites W4238942122 @default.
- W2016243384 doi "https://doi.org/10.1016/j.brainres.2007.06.071" @default.
- W2016243384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17706941" @default.
- W2016243384 hasPublicationYear "2007" @default.
- W2016243384 type Work @default.
- W2016243384 sameAs 2016243384 @default.
- W2016243384 citedByCount "28" @default.
- W2016243384 countsByYear W20162433842012 @default.
- W2016243384 countsByYear W20162433842013 @default.
- W2016243384 countsByYear W20162433842014 @default.
- W2016243384 countsByYear W20162433842015 @default.
- W2016243384 countsByYear W20162433842016 @default.
- W2016243384 countsByYear W20162433842017 @default.
- W2016243384 countsByYear W20162433842018 @default.
- W2016243384 countsByYear W20162433842021 @default.
- W2016243384 countsByYear W20162433842022 @default.
- W2016243384 crossrefType "journal-article" @default.
- W2016243384 hasAuthorship W2016243384A5020289992 @default.
- W2016243384 hasAuthorship W2016243384A5036118230 @default.
- W2016243384 hasAuthorship W2016243384A5040836134 @default.
- W2016243384 hasAuthorship W2016243384A5072838750 @default.
- W2016243384 hasConcept C126322002 @default.
- W2016243384 hasConcept C150903083 @default.
- W2016243384 hasConcept C207001950 @default.
- W2016243384 hasConcept C25938499 @default.
- W2016243384 hasConcept C2776359302 @default.
- W2016243384 hasConcept C2779306644 @default.
- W2016243384 hasConcept C2779311647 @default.
- W2016243384 hasConcept C2779872217 @default.
- W2016243384 hasConcept C42219234 @default.
- W2016243384 hasConcept C541997718 @default.
- W2016243384 hasConcept C71924100 @default.
- W2016243384 hasConcept C83743174 @default.
- W2016243384 hasConcept C86803240 @default.
- W2016243384 hasConcept C98274493 @default.
- W2016243384 hasConceptScore W2016243384C126322002 @default.
- W2016243384 hasConceptScore W2016243384C150903083 @default.
- W2016243384 hasConceptScore W2016243384C207001950 @default.
- W2016243384 hasConceptScore W2016243384C25938499 @default.
- W2016243384 hasConceptScore W2016243384C2776359302 @default.
- W2016243384 hasConceptScore W2016243384C2779306644 @default.
- W2016243384 hasConceptScore W2016243384C2779311647 @default.
- W2016243384 hasConceptScore W2016243384C2779872217 @default.
- W2016243384 hasConceptScore W2016243384C42219234 @default.
- W2016243384 hasConceptScore W2016243384C541997718 @default.
- W2016243384 hasConceptScore W2016243384C71924100 @default.
- W2016243384 hasConceptScore W2016243384C83743174 @default.
- W2016243384 hasConceptScore W2016243384C86803240 @default.
- W2016243384 hasConceptScore W2016243384C98274493 @default.
- W2016243384 hasLocation W20162433841 @default.
- W2016243384 hasLocation W20162433842 @default.
- W2016243384 hasOpenAccess W2016243384 @default.