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- W2016244057 abstract "We have previously shown that DNA elements controlling tissue specific expression of the rat thyroglobulin gene extend 170 bp upstream of the cap site and have identified a thyroid specific nuclear factor which binds the promoter in the −60 region (site C). Here we report that the distal portion of the promoter, extending from −160 to −120, contains two contiguous DNA elements (sites A and B) which interact with the same thyroid-specific factor binding to proximal site C. A second nuclear factor, ubiquitously distributed, binds to the distal site A. Transient cotransfection-competition studies show that all the three binding sites A, B and C titrate a trans-acting factor(s) which is necessary for the transcription of the thyroglobulin gene." @default.
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- W2016244057 date "1989-08-01" @default.
- W2016244057 modified "2023-09-28" @default.
- W2016244057 title "Protein binding domains of the rat thyroglobulin promoter" @default.
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- W2016244057 doi "https://doi.org/10.1016/0006-291x(89)92162-1" @default.
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