Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016247267> ?p ?o ?g. }
- W2016247267 endingPage "728" @default.
- W2016247267 startingPage "713" @default.
- W2016247267 abstract "Enterovirus 71 has been implicated in several outbreaks of hand, foot and mouth disease in the Asia-Pacific region. The present study aimed to achieve comprehensive evolutionary dynamic aspects of EV71 during 1994–2013, based on phylogenetic analyses of the VP1 sequences. The results indicated that 4 genotypes, namely C4, C1, C2 and B4 are the predominant strains, especially in Southeast Asian countries. No common ancestor was shared in different countries. Fourteen sites of substitutions were detected in the VP1 gene sequences; including the most common sites related to neutralization at position V249I [47.1% (189/401)] and A289T [42.6% (171/401)]. However, the sites Q22H and Q22R associated with increased virulence were recognized only in 13.7% (55/401) and 18% (72/401), respectively. None of the above mutations seemed to become fixed because the ratio of Ka/Ks was greater than 1.0. Mutations K43E, A58T, S184T, and T240S could possibly change the spatial structure. Two mutations, G145E and T240S, could obviously affect the hydrophobicity of VP1 and thus alter the EV71 immunoreactivity. In conclusion, the VP1 gene of EV71 strains circulating in the Asia-Pacific region during 1994–2013, showed polymorphisms and divergence with very slow evolution rate, which may be one of the reasons for periodic outbreaks in this area." @default.
- W2016247267 created "2016-06-24" @default.
- W2016247267 creator A5002287326 @default.
- W2016247267 creator A5006012404 @default.
- W2016247267 creator A5022341130 @default.
- W2016247267 creator A5027387813 @default.
- W2016247267 creator A5043493952 @default.
- W2016247267 creator A5066759596 @default.
- W2016247267 creator A5068355510 @default.
- W2016247267 creator A5068535394 @default.
- W2016247267 creator A5079211027 @default.
- W2016247267 creator A5086689963 @default.
- W2016247267 date "2013-11-01" @default.
- W2016247267 modified "2023-10-18" @default.
- W2016247267 title "Patterns of polymorphism and divergence in the VP1 gene of enterovirus 71 circulating in the Asia-Pacific region between 1994 and 2013" @default.
- W2016247267 cites W1880845650 @default.
- W2016247267 cites W1963557660 @default.
- W2016247267 cites W1963850809 @default.
- W2016247267 cites W1967665983 @default.
- W2016247267 cites W1968890801 @default.
- W2016247267 cites W1973667633 @default.
- W2016247267 cites W1978898017 @default.
- W2016247267 cites W1985006736 @default.
- W2016247267 cites W1987104397 @default.
- W2016247267 cites W1988381117 @default.
- W2016247267 cites W1989387089 @default.
- W2016247267 cites W1996651614 @default.
- W2016247267 cites W2000707546 @default.
- W2016247267 cites W2004408368 @default.
- W2016247267 cites W2005758406 @default.
- W2016247267 cites W2012819919 @default.
- W2016247267 cites W2018286595 @default.
- W2016247267 cites W2022439718 @default.
- W2016247267 cites W2026706600 @default.
- W2016247267 cites W2027491116 @default.
- W2016247267 cites W2027611340 @default.
- W2016247267 cites W2032290412 @default.
- W2016247267 cites W2036310174 @default.
- W2016247267 cites W2038403644 @default.
- W2016247267 cites W2040461364 @default.
- W2016247267 cites W2043389934 @default.
- W2016247267 cites W2049376874 @default.
- W2016247267 cites W2060809301 @default.
- W2016247267 cites W2062876847 @default.
- W2016247267 cites W2078183805 @default.
- W2016247267 cites W2080138827 @default.
- W2016247267 cites W2083468489 @default.
- W2016247267 cites W2087572168 @default.
- W2016247267 cites W2093313353 @default.
- W2016247267 cites W2093639082 @default.
- W2016247267 cites W2096420865 @default.
- W2016247267 cites W2099315132 @default.
- W2016247267 cites W2100008113 @default.
- W2016247267 cites W2100870450 @default.
- W2016247267 cites W2104244040 @default.
- W2016247267 cites W2105353162 @default.
- W2016247267 cites W2107140272 @default.
- W2016247267 cites W2110599330 @default.
- W2016247267 cites W2113543279 @default.
- W2016247267 cites W2117195081 @default.
- W2016247267 cites W2120950675 @default.
- W2016247267 cites W2123753779 @default.
- W2016247267 cites W2126073956 @default.
- W2016247267 cites W2135857095 @default.
- W2016247267 cites W2136790268 @default.
- W2016247267 cites W2144916816 @default.
- W2016247267 cites W2146067302 @default.
- W2016247267 cites W2149886005 @default.
- W2016247267 cites W2153545807 @default.
- W2016247267 cites W2153819224 @default.
- W2016247267 cites W2154283429 @default.
- W2016247267 cites W2155972879 @default.
- W2016247267 cites W2158606300 @default.
- W2016247267 cites W2162794587 @default.
- W2016247267 cites W2165892911 @default.
- W2016247267 cites W2169001784 @default.
- W2016247267 cites W2315624236 @default.
- W2016247267 cites W2333742702 @default.
- W2016247267 doi "https://doi.org/10.1016/j.jviromet.2013.07.051" @default.
- W2016247267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23933074" @default.
- W2016247267 hasPublicationYear "2013" @default.
- W2016247267 type Work @default.
- W2016247267 sameAs 2016247267 @default.
- W2016247267 citedByCount "16" @default.
- W2016247267 countsByYear W20162472672014 @default.
- W2016247267 countsByYear W20162472672015 @default.
- W2016247267 countsByYear W20162472672016 @default.
- W2016247267 countsByYear W20162472672017 @default.
- W2016247267 countsByYear W20162472672018 @default.
- W2016247267 countsByYear W20162472672020 @default.
- W2016247267 countsByYear W20162472672021 @default.
- W2016247267 countsByYear W20162472672022 @default.
- W2016247267 crossrefType "journal-article" @default.
- W2016247267 hasAuthorship W2016247267A5002287326 @default.
- W2016247267 hasAuthorship W2016247267A5006012404 @default.
- W2016247267 hasAuthorship W2016247267A5022341130 @default.
- W2016247267 hasAuthorship W2016247267A5027387813 @default.
- W2016247267 hasAuthorship W2016247267A5043493952 @default.