FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016251173> ?p ?o ?g. }

• W2016251173 endingPage "1922" @default.
• W2016251173 startingPage "1917" @default.
• W2016251173 abstract "Between March 1990 and December 1994, 316 consecutive children with localised neuroblastoma were registered in the French NBL 90 study. In addition to the assessment of a new chemotherapy regimen in unresectable neuroblastoma, we evaluated the prognostic significance of MYCN amplification and loss of the short arm of chromosome 1 (LOH1p). MYCN was found in 22/225 children (10%) and associated with unfavourable clinical features such as age at diagnosis > 1 year and large and unresectable tumours. LOH1p was observed in 9/91 patients (10%), of whom some had favourable prognostic factors such as age at diagnosis < 1 year (n = 4), INSS stage 1 or 2 (n = 3) and no MYCN amplification (n = 4). Overall survival (OS) and event-free survival (EFS) were, respectively, 56% and 22% (median follow-up: 36 months) for children with LOH1p compared with 97% and 94% for those without (log-rank = 10−8). All except 1 of the 5 children with MYCN amplification and LOH1p relapsed and ultimately died of the disease. Among the 4 with LOH1p and no MYCN amplification, recurrence occurred in 3 (2 local, 1 metastatic), all alive in second remission after salvage therapy (12–19 months after the relapse). In multivariate analysis, LOH1p was the strongest prognostic indicator for subsequent relapse. LOH1p appears more discriminant than MYCN amplification for predicting the risk of recurrence in children with localised neuroblastoma. However, its analysis was possible in only 30% of our patients and its final impact on survival should be confirmed in larger, prospective studies in order to stratify subsequent treatment." @default.
• W2016251173 created "2016-06-24" @default.
• W2016251173 creator A5007701213 @default.
• W2016251173 creator A5018479327 @default.
• W2016251173 creator A5025063054 @default.
• W2016251173 creator A5027448217 @default.
• W2016251173 creator A5029619328 @default.
• W2016251173 creator A5033870647 @default.
• W2016251173 creator A5036592214 @default.
• W2016251173 creator A5049198404 @default.
• W2016251173 creator A5056684913 @default.
• W2016251173 creator A5062385469 @default.
• W2016251173 creator A5062827900 @default.
• W2016251173 creator A5071022729 @default.
• W2016251173 creator A5072146290 @default.
• W2016251173 creator A5075229558 @default.
• W2016251173 date "1997-10-01" @default.
• W2016251173 modified "2023-09-26" @default.
• W2016251173 title "Loss of chromosome 1p may have a prognostic value in localised Neuroblastoma: results of the French NBL 90 study" @default.
• W2016251173 cites W1854022682 @default.
• W2016251173 cites W1920335633 @default.
• W2016251173 cites W1962288837 @default.
• W2016251173 cites W1978737996 @default.
• W2016251173 cites W1979247735 @default.
• W2016251173 cites W1981028064 @default.
• W2016251173 cites W1993610674 @default.
• W2016251173 cites W1997898033 @default.
• W2016251173 cites W2031245636 @default.
• W2016251173 cites W2035025012 @default.
• W2016251173 cites W2039061731 @default.
• W2016251173 cites W2042503478 @default.
• W2016251173 cites W2050109646 @default.
• W2016251173 cites W2054759420 @default.
• W2016251173 cites W2070272322 @default.
• W2016251173 cites W2077781687 @default.
• W2016251173 cites W2081491684 @default.
• W2016251173 cites W2093202549 @default.
• W2016251173 cites W2096398040 @default.
• W2016251173 cites W2132604294 @default.
• W2016251173 cites W2138509410 @default.
• W2016251173 cites W2162697934 @default.
• W2016251173 cites W4237455119 @default.
• W2016251173 doi "https://doi.org/10.1016/s0959-8049(97)00295-5" @default.
• W2016251173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9516824" @default.
• W2016251173 hasPublicationYear "1997" @default.
• W2016251173 type Work @default.
• W2016251173 sameAs 2016251173 @default.
• W2016251173 citedByCount "31" @default.
• W2016251173 countsByYear W20162511732012 @default.
• W2016251173 countsByYear W20162511732016 @default.
• W2016251173 countsByYear W20162511732020 @default.
• W2016251173 crossrefType "journal-article" @default.
• W2016251173 hasAuthorship W2016251173A5007701213 @default.
• W2016251173 hasAuthorship W2016251173A5018479327 @default.
• W2016251173 hasAuthorship W2016251173A5025063054 @default.
• W2016251173 hasAuthorship W2016251173A5027448217 @default.
• W2016251173 hasAuthorship W2016251173A5029619328 @default.
• W2016251173 hasAuthorship W2016251173A5033870647 @default.
• W2016251173 hasAuthorship W2016251173A5036592214 @default.
• W2016251173 hasAuthorship W2016251173A5049198404 @default.
• W2016251173 hasAuthorship W2016251173A5056684913 @default.
• W2016251173 hasAuthorship W2016251173A5062385469 @default.
• W2016251173 hasAuthorship W2016251173A5062827900 @default.
• W2016251173 hasAuthorship W2016251173A5071022729 @default.
• W2016251173 hasAuthorship W2016251173A5072146290 @default.
• W2016251173 hasAuthorship W2016251173A5075229558 @default.
• W2016251173 hasConcept C126322002 @default.
• W2016251173 hasConcept C143998085 @default.
• W2016251173 hasConcept C146357865 @default.
• W2016251173 hasConcept C151730666 @default.
• W2016251173 hasConcept C2776694085 @default.
• W2016251173 hasConcept C2776715637 @default.
• W2016251173 hasConcept C2781413609 @default.
• W2016251173 hasConcept C38180746 @default.
• W2016251173 hasConcept C54355233 @default.
• W2016251173 hasConcept C71924100 @default.
• W2016251173 hasConcept C81885089 @default.
• W2016251173 hasConcept C86803240 @default.
• W2016251173 hasConceptScore W2016251173C126322002 @default.
• W2016251173 hasConceptScore W2016251173C143998085 @default.
• W2016251173 hasConceptScore W2016251173C146357865 @default.
• W2016251173 hasConceptScore W2016251173C151730666 @default.
• W2016251173 hasConceptScore W2016251173C2776694085 @default.
• W2016251173 hasConceptScore W2016251173C2776715637 @default.
• W2016251173 hasConceptScore W2016251173C2781413609 @default.
• W2016251173 hasConceptScore W2016251173C38180746 @default.
• W2016251173 hasConceptScore W2016251173C54355233 @default.
• W2016251173 hasConceptScore W2016251173C71924100 @default.
• W2016251173 hasConceptScore W2016251173C81885089 @default.
• W2016251173 hasConceptScore W2016251173C86803240 @default.
• W2016251173 hasIssue "12" @default.
• W2016251173 hasLocation W20162511731 @default.
• W2016251173 hasLocation W20162511732 @default.
• W2016251173 hasOpenAccess W2016251173 @default.
• W2016251173 hasPrimaryLocation W20162511731 @default.
• W2016251173 hasRelatedWork W1838867428 @default.
• W2016251173 hasRelatedWork W1984282923 @default.
• W2016251173 hasRelatedWork W1987468340 @default.

• next