Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016255028> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2016255028 endingPage "112" @default.
- W2016255028 startingPage "109" @default.
- W2016255028 abstract "Intestinal epithelial cells (IEC) are hyporesponsive to LPS. Responsiveness to luminal bacteria has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). In support of this, previous studies have demonstrated that some intestinal epithelial cell lines are induced by IFN-γ to respond to LPS. However, both the responsiveness to LPS and the effect of IFN-γ in intestinal cell lines are heterogeneous. In addition, IFN-γ may be sequestered in the extracellular matrix (ECM) compartment. The ECM-bound form is more effective than soluble IFN-γ in producing its biological effects in several experimental models. We investigated the effect of ECM-bound and soluble IFN-γ treatment on interleukin-8 (IL-8) secretion in response to LPS in freshly isolated villous and crypt cells. We demonstrate that ECM-bound, but not soluble IFN-γ, induced an increase in IL-8 secretion in response to LPS in undifferentiated crypt cells. This effect was associated with an increase in TLR4 expression. In contrast, mature villous cells did not modify their response to LPS when treated with IFN-γ (ECM-bound or soluble). These results suggest that selective changes in immature crypt cells induced by IFN-γ bound to extracellular matrix could contribute to inappropriate responsiveness to commensal bacteria in IBD." @default.
- W2016255028 created "2016-06-24" @default.
- W2016255028 creator A5007750770 @default.
- W2016255028 creator A5019779395 @default.
- W2016255028 creator A5079797215 @default.
- W2016255028 creator A5087545112 @default.
- W2016255028 date "2005-06-15" @default.
- W2016255028 modified "2023-10-14" @default.
- W2016255028 title "Interferon gamma bound to extracellular matrix changes the hyporesponsiveness to LPS in crypt but not villous intestinal epithelial cells" @default.
- W2016255028 cites W1969411212 @default.
- W2016255028 cites W1980485021 @default.
- W2016255028 cites W1983021687 @default.
- W2016255028 cites W1984666000 @default.
- W2016255028 cites W1990296143 @default.
- W2016255028 cites W1990586383 @default.
- W2016255028 cites W1994707452 @default.
- W2016255028 cites W2023040110 @default.
- W2016255028 cites W2079978538 @default.
- W2016255028 cites W2110223162 @default.
- W2016255028 cites W2123880463 @default.
- W2016255028 cites W2146906769 @default.
- W2016255028 cites W2150091176 @default.
- W2016255028 cites W2167022200 @default.
- W2016255028 cites W2167215692 @default.
- W2016255028 doi "https://doi.org/10.1016/j.imlet.2005.02.005" @default.
- W2016255028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15894119" @default.
- W2016255028 hasPublicationYear "2005" @default.
- W2016255028 type Work @default.
- W2016255028 sameAs 2016255028 @default.
- W2016255028 citedByCount "11" @default.
- W2016255028 countsByYear W20162550282015 @default.
- W2016255028 countsByYear W20162550282020 @default.
- W2016255028 countsByYear W20162550282022 @default.
- W2016255028 crossrefType "journal-article" @default.
- W2016255028 hasAuthorship W2016255028A5007750770 @default.
- W2016255028 hasAuthorship W2016255028A5019779395 @default.
- W2016255028 hasAuthorship W2016255028A5079797215 @default.
- W2016255028 hasAuthorship W2016255028A5087545112 @default.
- W2016255028 hasConcept C126322002 @default.
- W2016255028 hasConcept C134018914 @default.
- W2016255028 hasConcept C189165786 @default.
- W2016255028 hasConcept C203014093 @default.
- W2016255028 hasConcept C2778690821 @default.
- W2016255028 hasConcept C2780841837 @default.
- W2016255028 hasConcept C2781077229 @default.
- W2016255028 hasConcept C28406088 @default.
- W2016255028 hasConcept C3019368612 @default.
- W2016255028 hasConcept C49039625 @default.
- W2016255028 hasConcept C529295009 @default.
- W2016255028 hasConcept C54355233 @default.
- W2016255028 hasConcept C66090201 @default.
- W2016255028 hasConcept C71924100 @default.
- W2016255028 hasConcept C86803240 @default.
- W2016255028 hasConcept C95444343 @default.
- W2016255028 hasConceptScore W2016255028C126322002 @default.
- W2016255028 hasConceptScore W2016255028C134018914 @default.
- W2016255028 hasConceptScore W2016255028C189165786 @default.
- W2016255028 hasConceptScore W2016255028C203014093 @default.
- W2016255028 hasConceptScore W2016255028C2778690821 @default.
- W2016255028 hasConceptScore W2016255028C2780841837 @default.
- W2016255028 hasConceptScore W2016255028C2781077229 @default.
- W2016255028 hasConceptScore W2016255028C28406088 @default.
- W2016255028 hasConceptScore W2016255028C3019368612 @default.
- W2016255028 hasConceptScore W2016255028C49039625 @default.
- W2016255028 hasConceptScore W2016255028C529295009 @default.
- W2016255028 hasConceptScore W2016255028C54355233 @default.
- W2016255028 hasConceptScore W2016255028C66090201 @default.
- W2016255028 hasConceptScore W2016255028C71924100 @default.
- W2016255028 hasConceptScore W2016255028C86803240 @default.
- W2016255028 hasConceptScore W2016255028C95444343 @default.
- W2016255028 hasIssue "1" @default.
- W2016255028 hasLocation W20162550281 @default.
- W2016255028 hasLocation W20162550282 @default.
- W2016255028 hasOpenAccess W2016255028 @default.
- W2016255028 hasPrimaryLocation W20162550281 @default.
- W2016255028 hasRelatedWork W2001146782 @default.
- W2016255028 hasRelatedWork W2016255028 @default.
- W2016255028 hasRelatedWork W2048988574 @default.
- W2016255028 hasRelatedWork W2073491069 @default.
- W2016255028 hasRelatedWork W2085726281 @default.
- W2016255028 hasRelatedWork W2115875451 @default.
- W2016255028 hasRelatedWork W2154157752 @default.
- W2016255028 hasRelatedWork W2180307689 @default.
- W2016255028 hasRelatedWork W2375463170 @default.
- W2016255028 hasRelatedWork W2915964548 @default.
- W2016255028 hasVolume "99" @default.
- W2016255028 isParatext "false" @default.
- W2016255028 isRetracted "false" @default.
- W2016255028 magId "2016255028" @default.
- W2016255028 workType "article" @default.