FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016259491> ?p ?o ?g. }

• W2016259491 endingPage "5240" @default.
• W2016259491 startingPage "5231" @default.
• W2016259491 abstract "Understanding the structural parameters of cationic amphiphiles which can influence gene transfer efficiencies of cationic amphiphiles continues to remain important for designing efficient liposomal gene delivery reagents. Previously we demonstrated the influence of structural orientation of the ester linker (widely used in covalently tethering the polar head and the non-polar tails) in modulating in vitro gene transfer efficiencies of cationic amphiphiles. However, our previously described cationic amphiphiles with ester linkers failed to deliver genes under in vivo conditions. Herein we report on the development of a highly serum compatible cationic amphiphile with circulation stable amide linker which shows remarkable selectivity in transfecting mouse lung. We also demonstrate that reversing structural orientation of the amide linker adversely affects both serum compatibility and the lung selective gene transfer property. Dynamic laser light scattering and atomic force microscopic studies revealed smaller average hydrodynamic sizes of the liposomes of transfection efficient lipid than those for the liposomes of transfection incompetent analog (148 ± 1 nm vs 214 ± 4 nm). Average surface potential of the liposomes of transfection competent amphiphiles were found to be significantly higher than that for the liposomes of transfection incompetent analog (10.7 ± 5.4 mV vs 2.8 ± 1.3 mV, respectively). Findings in fluorescence resonance energy transfer and dye entrapment experiments support lower rigidity and higher biomembrane fusogenicity of the liposomes of the transfection efficient amphiphiles. Importantly, cationic lipoplexes of the novel amide-linker based amphiphile exhibited higher mouse lung selective gene transfer properties than DOTAP, one of the widely used commercially available liposomal lung transfection kits. In summary, the present findings demonstrate for the first time that amide linker structural orientation profoundly influences the serum compatibility and lung transfection efficiencies of cationic amphiphiles." @default.
• W2016259491 created "2016-06-24" @default.
• W2016259491 creator A5003507674 @default.
• W2016259491 creator A5025527318 @default.
• W2016259491 creator A5027753470 @default.
• W2016259491 creator A5029919048 @default.
• W2016259491 creator A5036676157 @default.
• W2016259491 creator A5053661230 @default.
• W2016259491 date "2011-08-01" @default.
• W2016259491 modified "2023-10-06" @default.
• W2016259491 title "The influence of the structural orientation of amide linkers on the serum compatibility and lung transfection properties of cationic amphiphiles" @default.
• W2016259491 cites W1579604458 @default.
• W2016259491 cites W1597166608 @default.
• W2016259491 cites W1965183865 @default.
• W2016259491 cites W1968232819 @default.
• W2016259491 cites W1976807231 @default.
• W2016259491 cites W1986700596 @default.
• W2016259491 cites W1988289069 @default.
• W2016259491 cites W1988752768 @default.
• W2016259491 cites W1996491430 @default.
• W2016259491 cites W2004759340 @default.
• W2016259491 cites W2006262570 @default.
• W2016259491 cites W2012300444 @default.
• W2016259491 cites W2015863802 @default.
• W2016259491 cites W2031423487 @default.
• W2016259491 cites W2033776334 @default.
• W2016259491 cites W2045941430 @default.
• W2016259491 cites W2070470578 @default.
• W2016259491 cites W2071404078 @default.
• W2016259491 cites W2073699878 @default.
• W2016259491 cites W2073822955 @default.
• W2016259491 cites W2081558960 @default.
• W2016259491 cites W2086875461 @default.
• W2016259491 cites W2087403976 @default.
• W2016259491 cites W2090830175 @default.
• W2016259491 cites W2105413362 @default.
• W2016259491 cites W2105582248 @default.
• W2016259491 cites W2119591046 @default.
• W2016259491 cites W2122082335 @default.
• W2016259491 cites W2144892927 @default.
• W2016259491 cites W2158519239 @default.
• W2016259491 cites W2314516700 @default.
• W2016259491 cites W2950914253 @default.
• W2016259491 doi "https://doi.org/10.1016/j.biomaterials.2011.03.059" @default.
• W2016259491 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21501864" @default.
• W2016259491 hasPublicationYear "2011" @default.
• W2016259491 type Work @default.
• W2016259491 sameAs 2016259491 @default.
• W2016259491 citedByCount "36" @default.
• W2016259491 countsByYear W20162594912012 @default.
• W2016259491 countsByYear W20162594912013 @default.
• W2016259491 countsByYear W20162594912014 @default.
• W2016259491 countsByYear W20162594912015 @default.
• W2016259491 countsByYear W20162594912016 @default.
• W2016259491 countsByYear W20162594912017 @default.
• W2016259491 countsByYear W20162594912018 @default.
• W2016259491 countsByYear W20162594912019 @default.
• W2016259491 countsByYear W20162594912021 @default.
• W2016259491 countsByYear W20162594912022 @default.
• W2016259491 countsByYear W20162594912023 @default.
• W2016259491 crossrefType "journal-article" @default.
• W2016259491 hasAuthorship W2016259491A5003507674 @default.
• W2016259491 hasAuthorship W2016259491A5025527318 @default.
• W2016259491 hasAuthorship W2016259491A5027753470 @default.
• W2016259491 hasAuthorship W2016259491A5029919048 @default.
• W2016259491 hasAuthorship W2016259491A5036676157 @default.
• W2016259491 hasAuthorship W2016259491A5053661230 @default.
• W2016259491 hasConcept C104317684 @default.
• W2016259491 hasConcept C111919701 @default.
• W2016259491 hasConcept C12554922 @default.
• W2016259491 hasConcept C135983454 @default.
• W2016259491 hasConcept C155887181 @default.
• W2016259491 hasConcept C15920480 @default.
• W2016259491 hasConcept C171250308 @default.
• W2016259491 hasConcept C178790620 @default.
• W2016259491 hasConcept C183882617 @default.
• W2016259491 hasConcept C185154212 @default.
• W2016259491 hasConcept C185592680 @default.
• W2016259491 hasConcept C188027245 @default.
• W2016259491 hasConcept C192562407 @default.
• W2016259491 hasConcept C21951064 @default.
• W2016259491 hasConcept C2780557392 @default.
• W2016259491 hasConcept C41008148 @default.
• W2016259491 hasConcept C521977710 @default.
• W2016259491 hasConcept C54009773 @default.
• W2016259491 hasConcept C55493867 @default.
• W2016259491 hasConcept C67407626 @default.
• W2016259491 hasConcept C86803240 @default.
• W2016259491 hasConceptScore W2016259491C104317684 @default.
• W2016259491 hasConceptScore W2016259491C111919701 @default.
• W2016259491 hasConceptScore W2016259491C12554922 @default.
• W2016259491 hasConceptScore W2016259491C135983454 @default.
• W2016259491 hasConceptScore W2016259491C155887181 @default.
• W2016259491 hasConceptScore W2016259491C15920480 @default.
• W2016259491 hasConceptScore W2016259491C171250308 @default.
• W2016259491 hasConceptScore W2016259491C178790620 @default.
• W2016259491 hasConceptScore W2016259491C183882617 @default.
• W2016259491 hasConceptScore W2016259491C185154212 @default.

• next