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- W2016262076 endingPage "860" @default.
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- W2016262076 abstract "Existence of cellular structures with specific size raises a fundamental question in biology: How do cells measure length? One conceptual answer to this question is by a molecular ruler, but examples of such rulers in eukaryotes are lacking. In this work, we identified a molecular ruler in eukaryotic cilia and flagella. Using cryo-electron tomography, we found that FAP59 and FAP172 form a 96–nanometer (nm)–long complex in Chlamydomonas flagella and that the absence of the complex disrupted 96-nm repeats of axonemes. Furthermore, lengthening of the FAP59/172 complex by domain duplication resulted in extension of the repeats up to 128 nm, as well as duplication of specific axonemal components. Thus, the FAP59/172 complex is the molecular ruler that determines the 96-nm repeat length and arrangements of components in cilia and flagella." @default.
- W2016262076 created "2016-06-24" @default.
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- W2016262076 date "2014-11-14" @default.
- W2016262076 modified "2023-10-15" @default.
- W2016262076 title "A molecular ruler determines the repeat length in eukaryotic cilia and flagella" @default.
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- W2016262076 doi "https://doi.org/10.1126/science.1260214" @default.
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