Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016265642> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2016265642 endingPage "2351" @default.
- W2016265642 startingPage "2345" @default.
- W2016265642 abstract "The pharmacokinetics of temafloxacin were investigated following oral administration of single 400-mg doses to 6 normal subjects and 18 subjects with various degrees of impaired renal function. Renal impairment did not significantly affect the peak concentration, time to peak concentration, or the nonrenal clearance of temafloxacin. Both renal clearance (CLR) and total apparent clearance (CLT/F, where F represents the fraction of dose absorbed) of temafloxacin were highly correlated with creatinine clearance (CLCR). The regression equations were as follows: CLR = 0.85.CLCR, with R2 = 0.907, and CLT/F = 56.0 + 0.92.CLCR, with R2 = 0.656. The half-life (mean +/- standard deviation) increased from 10.6 +/- 2.4 h in the normal volunteers to 24.6 +/- 7.3 h in the subjects with a CLCR of less than 10 ml/min; the respective CLT/F decreased from 169 +/- 58 to 70 +/- 27 ml/min. Compared with the CLT/F in the subjects with normal renal function, CLT/F was reduced 60% in subjects with a CLCR of less than 40 ml/min, indicating that the dosage should be reduced by at least one-half for patients with comparable impairment. For the subjects on chronic hemodialysis, most of the variability in the nonrenal clearance and the terminal-phase rate constant of temafloxacin was associated with the quantity of calcium carbonate and related medication taken for the treatment of hyperphosphatemia. Supplemental dosage is not required for patients undergoing hemodialysis, since the distribution of temafloxacin in tissue is extensive and the recoveries from 4-h dialysis sessions accounted for less than 10% of the drug present at the start of the dialysis." @default.
- W2016265642 created "2016-06-24" @default.
- W2016265642 creator A5013170411 @default.
- W2016265642 creator A5023941702 @default.
- W2016265642 creator A5048239393 @default.
- W2016265642 creator A5066149189 @default.
- W2016265642 creator A5068463983 @default.
- W2016265642 date "1991-11-01" @default.
- W2016265642 modified "2023-09-27" @default.
- W2016265642 title "Temafloxacin pharmacokinetics in subjects with normal and impaired renal function" @default.
- W2016265642 cites W1966266543 @default.
- W2016265642 cites W1989382232 @default.
- W2016265642 cites W2002374879 @default.
- W2016265642 cites W2005815716 @default.
- W2016265642 cites W2014940592 @default.
- W2016265642 cites W2018901233 @default.
- W2016265642 cites W2019035120 @default.
- W2016265642 cites W2022704044 @default.
- W2016265642 cites W2034285673 @default.
- W2016265642 cites W2043383096 @default.
- W2016265642 cites W2054772937 @default.
- W2016265642 cites W2080525977 @default.
- W2016265642 cites W2092030428 @default.
- W2016265642 cites W2105998273 @default.
- W2016265642 cites W2106260621 @default.
- W2016265642 cites W2141265083 @default.
- W2016265642 cites W2165966372 @default.
- W2016265642 cites W2169170885 @default.
- W2016265642 cites W285082129 @default.
- W2016265642 doi "https://doi.org/10.1128/aac.35.11.2345" @default.
- W2016265642 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/245383" @default.
- W2016265642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1666497" @default.
- W2016265642 hasPublicationYear "1991" @default.
- W2016265642 type Work @default.
- W2016265642 sameAs 2016265642 @default.
- W2016265642 citedByCount "13" @default.
- W2016265642 countsByYear W20162656422012 @default.
- W2016265642 crossrefType "journal-article" @default.
- W2016265642 hasAuthorship W2016265642A5013170411 @default.
- W2016265642 hasAuthorship W2016265642A5023941702 @default.
- W2016265642 hasAuthorship W2016265642A5048239393 @default.
- W2016265642 hasAuthorship W2016265642A5066149189 @default.
- W2016265642 hasAuthorship W2016265642A5068463983 @default.
- W2016265642 hasBestOaLocation W20162656422 @default.
- W2016265642 hasConcept C112705442 @default.
- W2016265642 hasConcept C126322002 @default.
- W2016265642 hasConcept C126894567 @default.
- W2016265642 hasConcept C139254425 @default.
- W2016265642 hasConcept C159641895 @default.
- W2016265642 hasConcept C192670549 @default.
- W2016265642 hasConcept C2776036575 @default.
- W2016265642 hasConcept C2777056448 @default.
- W2016265642 hasConcept C2778063415 @default.
- W2016265642 hasConcept C2778653478 @default.
- W2016265642 hasConcept C2908822073 @default.
- W2016265642 hasConcept C71924100 @default.
- W2016265642 hasConceptScore W2016265642C112705442 @default.
- W2016265642 hasConceptScore W2016265642C126322002 @default.
- W2016265642 hasConceptScore W2016265642C126894567 @default.
- W2016265642 hasConceptScore W2016265642C139254425 @default.
- W2016265642 hasConceptScore W2016265642C159641895 @default.
- W2016265642 hasConceptScore W2016265642C192670549 @default.
- W2016265642 hasConceptScore W2016265642C2776036575 @default.
- W2016265642 hasConceptScore W2016265642C2777056448 @default.
- W2016265642 hasConceptScore W2016265642C2778063415 @default.
- W2016265642 hasConceptScore W2016265642C2778653478 @default.
- W2016265642 hasConceptScore W2016265642C2908822073 @default.
- W2016265642 hasConceptScore W2016265642C71924100 @default.
- W2016265642 hasIssue "11" @default.
- W2016265642 hasLocation W20162656421 @default.
- W2016265642 hasLocation W20162656422 @default.
- W2016265642 hasOpenAccess W2016265642 @default.
- W2016265642 hasPrimaryLocation W20162656421 @default.
- W2016265642 hasRelatedWork W1597331470 @default.
- W2016265642 hasRelatedWork W1603001808 @default.
- W2016265642 hasRelatedWork W2016265642 @default.
- W2016265642 hasRelatedWork W2042399818 @default.
- W2016265642 hasRelatedWork W2050939826 @default.
- W2016265642 hasRelatedWork W2060590114 @default.
- W2016265642 hasRelatedWork W2114652467 @default.
- W2016265642 hasRelatedWork W2126121959 @default.
- W2016265642 hasRelatedWork W2159727847 @default.
- W2016265642 hasRelatedWork W2053525803 @default.
- W2016265642 hasVolume "35" @default.
- W2016265642 isParatext "false" @default.
- W2016265642 isRetracted "false" @default.
- W2016265642 magId "2016265642" @default.
- W2016265642 workType "article" @default.