FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016265973> ?p ?o ?g. }

• W2016265973 endingPage "6631" @default.
• W2016265973 startingPage "6620" @default.
• W2016265973 abstract "Two 1,3,5-trisubstituted aromatic scaffolds intended to serve as gamma-turn mimetics have been synthesized and incorporated in five pseudopeptide analogues of angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe), replacing Val-Tyr-Ile, Val-Tyr, or Tyr-Ile. All the tested compounds exhibited nanomolar affinity for the AT2 receptor with the best compound (3) having a K(i) of 1.85 nM. Four pseudopeptides were AT2 selective, while one (5) also exhibited good affinity for the AT1 receptor (K(i) = 30.3 nM). This pseudopeptide exerted full agonistic activity in an AT2 receptor induced neurite outgrowth assay but displayed no agonistic effect in an AT1 receptor functional assay. Molecular modeling, using the program DISCOtech, showed that the high-affinity ligands could interact similarly with the AT2 receptor as other ligands with high affinity for this receptor. A tentative agonist model is proposed for AT2 receptor activation by angiotensin II analogues. We conclude that the 1,3,5-trisubstituted benzene rings can be conveniently prepared and are suitable as gamma-turn mimics." @default.
• W2016265973 created "2016-06-24" @default.
• W2016265973 creator A5004010149 @default.
• W2016265973 creator A5008347976 @default.
• W2016265973 creator A5015789210 @default.
• W2016265973 creator A5019902780 @default.
• W2016265973 creator A5037716681 @default.
• W2016265973 creator A5038720064 @default.
• W2016265973 creator A5046352749 @default.
• W2016265973 creator A5047841423 @default.
• W2016265973 creator A5058195012 @default.
• W2016265973 creator A5086713415 @default.
• W2016265973 creator A5091477954 @default.
• W2016265973 date "2005-09-23" @default.
• W2016265973 modified "2023-10-16" @default.
• W2016265973 title "Angiotensin II Pseudopeptides Containing 1,3,5-Trisubstituted Benzene Scaffolds with High AT₂ Receptor Affinity" @default.
• W2016265973 cites W1527240164 @default.
• W2016265973 cites W1591510379 @default.
• W2016265973 cites W1935853419 @default.
• W2016265973 cites W1965234607 @default.
• W2016265973 cites W1965599418 @default.
• W2016265973 cites W1971410991 @default.
• W2016265973 cites W1973610173 @default.
• W2016265973 cites W1974814786 @default.
• W2016265973 cites W1976088649 @default.
• W2016265973 cites W1980878008 @default.
• W2016265973 cites W1982116062 @default.
• W2016265973 cites W1985314662 @default.
• W2016265973 cites W2005288968 @default.
• W2016265973 cites W2005730386 @default.
• W2016265973 cites W2012853816 @default.
• W2016265973 cites W2022352256 @default.
• W2016265973 cites W2029424515 @default.
• W2016265973 cites W2032267105 @default.
• W2016265973 cites W2039969698 @default.
• W2016265973 cites W2042771012 @default.
• W2016265973 cites W2046259472 @default.
• W2016265973 cites W2046311259 @default.
• W2016265973 cites W2046906382 @default.
• W2016265973 cites W2047730466 @default.
• W2016265973 cites W2049443318 @default.
• W2016265973 cites W2050062150 @default.
• W2016265973 cites W2057750448 @default.
• W2016265973 cites W2067224374 @default.
• W2016265973 cites W2067946831 @default.
• W2016265973 cites W2076155814 @default.
• W2016265973 cites W2076311301 @default.
• W2016265973 cites W2092811944 @default.
• W2016265973 cites W2092923062 @default.
• W2016265973 cites W2095139673 @default.
• W2016265973 cites W2115145235 @default.
• W2016265973 cites W2122167307 @default.
• W2016265973 cites W2130479394 @default.
• W2016265973 cites W2131124255 @default.
• W2016265973 cites W2137995988 @default.
• W2016265973 cites W2143118993 @default.
• W2016265973 cites W2168211076 @default.
• W2016265973 cites W2176519340 @default.
• W2016265973 cites W2330644927 @default.
• W2016265973 cites W2520864089 @default.
• W2016265973 doi "https://doi.org/10.1021/jm050280z" @default.
• W2016265973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16220978" @default.
• W2016265973 hasPublicationYear "2005" @default.
• W2016265973 type Work @default.
• W2016265973 sameAs 2016265973 @default.
• W2016265973 citedByCount "32" @default.
• W2016265973 countsByYear W20162659732012 @default.
• W2016265973 countsByYear W20162659732013 @default.
• W2016265973 countsByYear W20162659732014 @default.
• W2016265973 countsByYear W20162659732015 @default.
• W2016265973 countsByYear W20162659732018 @default.
• W2016265973 countsByYear W20162659732020 @default.
• W2016265973 countsByYear W20162659732021 @default.
• W2016265973 countsByYear W20162659732022 @default.
• W2016265973 crossrefType "journal-article" @default.
• W2016265973 hasAuthorship W2016265973A5004010149 @default.
• W2016265973 hasAuthorship W2016265973A5008347976 @default.
• W2016265973 hasAuthorship W2016265973A5015789210 @default.
• W2016265973 hasAuthorship W2016265973A5019902780 @default.
• W2016265973 hasAuthorship W2016265973A5037716681 @default.
• W2016265973 hasAuthorship W2016265973A5038720064 @default.
• W2016265973 hasAuthorship W2016265973A5046352749 @default.
• W2016265973 hasAuthorship W2016265973A5047841423 @default.
• W2016265973 hasAuthorship W2016265973A5058195012 @default.
• W2016265973 hasAuthorship W2016265973A5086713415 @default.
• W2016265973 hasAuthorship W2016265973A5091477954 @default.
• W2016265973 hasConcept C104849204 @default.
• W2016265973 hasConcept C123915805 @default.
• W2016265973 hasConcept C170493617 @default.
• W2016265973 hasConcept C178790620 @default.
• W2016265973 hasConcept C185592680 @default.
• W2016265973 hasConcept C21951064 @default.
• W2016265973 hasConcept C2777691172 @default.
• W2016265973 hasConcept C2778938600 @default.
• W2016265973 hasConcept C2908929049 @default.
• W2016265973 hasConcept C38533456 @default.
• W2016265973 hasConcept C55493867 @default.
• W2016265973 hasConcept C71240020 @default.

• next