FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016270524> ?p ?o ?g. }

• W2016270524 endingPage "7690" @default.
• W2016270524 startingPage "7682" @default.
• W2016270524 abstract "Sterols are not randomly distributed in membranes but appear to be localized in multiple kinetic domains. Factors that regulate these sterol domains are not well-understood. A recently developed fluorescence polarization assay that measures molecular sterol transfer [Butko, P., Hapala, I., Nemecz, G., of Schroeder, F. (1992) J. Biochem. Biophys. Methods 24, 15-37] was used to examine the mechanism whereby anionic phospholipids and liver sterol carrier protein-2 (SCP2) enhance sterol transfer. Two exchangeable and one very slowly or nonexchangeable sterol domain were resolved in phosphatidylcholine (POPC)/sterol small unilamellar vesicles (SUV). Inclusion of 10 mol % anionic phospholipids enhanced sterol exchange primarily by redistribution of sterol domain sizes rather than by alteration of half-times of exchange. This effect was dependent primarily on the percent content rather than the net charge per anionic phospholipid. In contrast, SCP2 simultaneously altered both the distribution of sterol molecules between kinetic domains and the exchange half-times of exchangeable sterol domains. The effects of SCP2 were much more pronounced when 10% acidic phospholipid was incorporated in the SUV. Compared to spontaneous sterol exchange, in the presence of 1.5 microM SCP2, the rapidly exchanging pool was increased by 36 to 330%, depending on the SUV phospholipid composition. Concomitantly, exchange half-times for rapidly and slowly exchangeable sterol were reduced by 60 to 98% for 1t1/2 and 14 to 85% for 2t1/2, respectively. The stimulatory effect of SCP2 was saturable and dependent both on protein concentration and on content of acidic phospholipids in membranes.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2016270524 created "2016-06-24" @default.
• W2016270524 creator A5015662840 @default.
• W2016270524 creator A5031197939 @default.
• W2016270524 creator A5046497078 @default.
• W2016270524 creator A5056126942 @default.
• W2016270524 creator A5064069076 @default.
• W2016270524 creator A5084458158 @default.
• W2016270524 date "1994-06-21" @default.
• W2016270524 modified "2023-09-29" @default.
• W2016270524 title "Regulation of Membrane Cholesterol Domains by Sterol Carrier Protein-2" @default.
• W2016270524 cites W112756771 @default.
• W2016270524 cites W120612389 @default.
• W2016270524 cites W1475880645 @default.
• W2016270524 cites W1484994078 @default.
• W2016270524 cites W1497888136 @default.
• W2016270524 cites W1504893374 @default.
• W2016270524 cites W1517753813 @default.
• W2016270524 cites W1527093201 @default.
• W2016270524 cites W1564979110 @default.
• W2016270524 cites W1582554183 @default.
• W2016270524 cites W1594286156 @default.
• W2016270524 cites W1964778282 @default.
• W2016270524 cites W1966380279 @default.
• W2016270524 cites W1970097948 @default.
• W2016270524 cites W1971091498 @default.
• W2016270524 cites W1978446647 @default.
• W2016270524 cites W1984849192 @default.
• W2016270524 cites W1985410104 @default.
• W2016270524 cites W1987697559 @default.
• W2016270524 cites W1990037440 @default.
• W2016270524 cites W1990332976 @default.
• W2016270524 cites W1999599285 @default.
• W2016270524 cites W2008441362 @default.
• W2016270524 cites W2009144858 @default.
• W2016270524 cites W2015553095 @default.
• W2016270524 cites W2016411005 @default.
• W2016270524 cites W2021672090 @default.
• W2016270524 cites W2027467236 @default.
• W2016270524 cites W2036078107 @default.
• W2016270524 cites W2040149610 @default.
• W2016270524 cites W2040171050 @default.
• W2016270524 cites W2041304269 @default.
• W2016270524 cites W2043483779 @default.
• W2016270524 cites W2043725904 @default.
• W2016270524 cites W2045225548 @default.
• W2016270524 cites W2045960588 @default.
• W2016270524 cites W2048980885 @default.
• W2016270524 cites W2054030121 @default.
• W2016270524 cites W2060438281 @default.
• W2016270524 cites W2078879474 @default.
• W2016270524 cites W2093167525 @default.
• W2016270524 cites W2108622508 @default.
• W2016270524 cites W2322069423 @default.
• W2016270524 cites W2340800860 @default.
• W2016270524 cites W2400412367 @default.
• W2016270524 cites W2915509740 @default.
• W2016270524 doi "https://doi.org/10.1021/bi00190a023" @default.
• W2016270524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8011635" @default.
• W2016270524 hasPublicationYear "1994" @default.
• W2016270524 type Work @default.
• W2016270524 sameAs 2016270524 @default.
• W2016270524 citedByCount "36" @default.
• W2016270524 countsByYear W20162705242021 @default.
• W2016270524 crossrefType "journal-article" @default.
• W2016270524 hasAuthorship W2016270524A5015662840 @default.
• W2016270524 hasAuthorship W2016270524A5031197939 @default.
• W2016270524 hasAuthorship W2016270524A5046497078 @default.
• W2016270524 hasAuthorship W2016270524A5056126942 @default.
• W2016270524 hasAuthorship W2016270524A5064069076 @default.
• W2016270524 hasAuthorship W2016270524A5084458158 @default.
• W2016270524 hasConcept C12554922 @default.
• W2016270524 hasConcept C130316041 @default.
• W2016270524 hasConcept C185592680 @default.
• W2016270524 hasConcept C2776330855 @default.
• W2016270524 hasConcept C2778163477 @default.
• W2016270524 hasConcept C2778718757 @default.
• W2016270524 hasConcept C2778918659 @default.
• W2016270524 hasConcept C2780943371 @default.
• W2016270524 hasConcept C41625074 @default.
• W2016270524 hasConcept C55493867 @default.
• W2016270524 hasConcept C86803240 @default.
• W2016270524 hasConceptScore W2016270524C12554922 @default.
• W2016270524 hasConceptScore W2016270524C130316041 @default.
• W2016270524 hasConceptScore W2016270524C185592680 @default.
• W2016270524 hasConceptScore W2016270524C2776330855 @default.
• W2016270524 hasConceptScore W2016270524C2778163477 @default.
• W2016270524 hasConceptScore W2016270524C2778718757 @default.
• W2016270524 hasConceptScore W2016270524C2778918659 @default.
• W2016270524 hasConceptScore W2016270524C2780943371 @default.
• W2016270524 hasConceptScore W2016270524C41625074 @default.
• W2016270524 hasConceptScore W2016270524C55493867 @default.
• W2016270524 hasConceptScore W2016270524C86803240 @default.
• W2016270524 hasIssue "24" @default.
• W2016270524 hasLocation W20162705241 @default.
• W2016270524 hasLocation W20162705242 @default.
• W2016270524 hasOpenAccess W2016270524 @default.
• W2016270524 hasPrimaryLocation W20162705241 @default.

• next