FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016271680> ?p ?o ?g. }

• W2016271680 endingPage "544" @default.
• W2016271680 startingPage "537" @default.
• W2016271680 abstract "SUMMARY p53 and p16 are both tumor suppressors. This article summarizes the current investigation status on their roles and interaction in triple-negative breast cancer (TNBC) to explore their potential as prognostic, predictive and therapeutic targets. There is significant evidence implicating that p53 mutation as a driver plays an important role in tumorigenesis and progression of TNBC. p53 mutations are more frequently observed in TNBCs compared with ER-positive breast cancers. The presence of a p53 mutation is associated with poorer prognosis in TNBC patients. The status of p53 protein expression divides TNBCs into two biologically distinct subgroups (p53-positive vs p53-negative); p53-positive tumors have more aggressive behavior. p53 has clinical prognostic utility and is a promising target candidate for directed therapy for TNBC patients. p16 appears to play a significant role in tumorigenesis of TNBC through the Rb/p16 dysfunction pathway. A high level of p16 protein expression is associated with aggressive behavior and tumor proliferation of TNBC. The status of p16 expression may have potential predictive value for TNBC response to chemotherapy; further investigation is needed to support the proposal. p16 expression has been strongly correlated with p53 expression in TNBC, suggesting interactions between the two mutations in tumorigenesis. It has been proposed that the two tumor suppressors appear to be involved in early events of TNBC formation with subsequent interplay resulting in their mutual inactivation and, ultimately, leading to a proliferative environment." @default.
• W2016271680 created "2016-06-24" @default.
• W2016271680 creator A5018225481 @default.
• W2016271680 creator A5085279098 @default.
• W2016271680 date "2013-11-01" @default.
• W2016271680 modified "2023-09-24" @default.
• W2016271680 title "Roles of p53 and p16 in triple-negative breast cancer" @default.
• W2016271680 cites W1976263258 @default.
• W2016271680 cites W1978760581 @default.
• W2016271680 cites W1984945725 @default.
• W2016271680 cites W1986076152 @default.
• W2016271680 cites W1989663680 @default.
• W2016271680 cites W1995788690 @default.
• W2016271680 cites W2004946118 @default.
• W2016271680 cites W2005895632 @default.
• W2016271680 cites W2019495648 @default.
• W2016271680 cites W2022289852 @default.
• W2016271680 cites W2027271208 @default.
• W2016271680 cites W2035114699 @default.
• W2016271680 cites W2045909049 @default.
• W2016271680 cites W2045937534 @default.
• W2016271680 cites W2055395862 @default.
• W2016271680 cites W2057487057 @default.
• W2016271680 cites W2064074669 @default.
• W2016271680 cites W2069653040 @default.
• W2016271680 cites W2070480410 @default.
• W2016271680 cites W2072544833 @default.
• W2016271680 cites W2093716073 @default.
• W2016271680 cites W2096027508 @default.
• W2016271680 cites W2097255042 @default.
• W2016271680 cites W2098098349 @default.
• W2016271680 cites W2098920248 @default.
• W2016271680 cites W2101063496 @default.
• W2016271680 cites W2103524011 @default.
• W2016271680 cites W2104638648 @default.
• W2016271680 cites W2111429259 @default.
• W2016271680 cites W2116052270 @default.
• W2016271680 cites W2118605519 @default.
• W2016271680 cites W2124742058 @default.
• W2016271680 cites W2125094267 @default.
• W2016271680 cites W2125292142 @default.
• W2016271680 cites W2134539328 @default.
• W2016271680 cites W2141223216 @default.
• W2016271680 cites W2142491513 @default.
• W2016271680 cites W2142625084 @default.
• W2016271680 cites W2142839601 @default.
• W2016271680 cites W2150883726 @default.
• W2016271680 cites W2155757744 @default.
• W2016271680 cites W2157375575 @default.
• W2016271680 cites W2160928966 @default.
• W2016271680 cites W2161426850 @default.
• W2016271680 cites W2165884472 @default.
• W2016271680 cites W2168390839 @default.
• W2016271680 cites W2171972386 @default.
• W2016271680 cites W2317808775 @default.
• W2016271680 cites W2564823279 @default.
• W2016271680 cites W4238877081 @default.
• W2016271680 cites W2090696401 @default.
• W2016271680 doi "https://doi.org/10.2217/bmt.13.59" @default.
• W2016271680 hasPublicationYear "2013" @default.
• W2016271680 type Work @default.
• W2016271680 sameAs 2016271680 @default.
• W2016271680 citedByCount "14" @default.
• W2016271680 countsByYear W20162716802014 @default.
• W2016271680 countsByYear W20162716802015 @default.
• W2016271680 countsByYear W20162716802016 @default.
• W2016271680 countsByYear W20162716802017 @default.
• W2016271680 countsByYear W20162716802019 @default.
• W2016271680 countsByYear W20162716802020 @default.
• W2016271680 countsByYear W20162716802021 @default.
• W2016271680 countsByYear W20162716802022 @default.
• W2016271680 crossrefType "journal-article" @default.
• W2016271680 hasAuthorship W2016271680A5018225481 @default.
• W2016271680 hasAuthorship W2016271680A5085279098 @default.
• W2016271680 hasConcept C104317684 @default.
• W2016271680 hasConcept C121608353 @default.
• W2016271680 hasConcept C126322002 @default.
• W2016271680 hasConcept C143998085 @default.
• W2016271680 hasConcept C179185449 @default.
• W2016271680 hasConcept C204232928 @default.
• W2016271680 hasConcept C2780110267 @default.
• W2016271680 hasConcept C3020813896 @default.
• W2016271680 hasConcept C501734568 @default.
• W2016271680 hasConcept C502942594 @default.
• W2016271680 hasConcept C530470458 @default.
• W2016271680 hasConcept C54355233 @default.
• W2016271680 hasConcept C555283112 @default.
• W2016271680 hasConcept C71924100 @default.
• W2016271680 hasConcept C86803240 @default.
• W2016271680 hasConceptScore W2016271680C104317684 @default.
• W2016271680 hasConceptScore W2016271680C121608353 @default.
• W2016271680 hasConceptScore W2016271680C126322002 @default.
• W2016271680 hasConceptScore W2016271680C143998085 @default.
• W2016271680 hasConceptScore W2016271680C179185449 @default.
• W2016271680 hasConceptScore W2016271680C204232928 @default.
• W2016271680 hasConceptScore W2016271680C2780110267 @default.
• W2016271680 hasConceptScore W2016271680C3020813896 @default.
• W2016271680 hasConceptScore W2016271680C501734568 @default.

• next