Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016272508> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2016272508 abstract "Eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropyloxy)vitamin D3] is an analog of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3], bearing a hydroxypropyloxy residue at the 2β position. In preclinical studies, eldecalcitol suppressed bone resorption to a greater extent than alfacalcidol but had a similar effect on bone formation and Ca metabolism, resulting in a greater increase in bone mineral density (BMD) in ovariectomized (OVX) rats. Histological analysis in OVX rats immediately after ovariectomy revealed that eldecalcitol reduced osteoclast number and bone resorption parameters with a decrease in bone formation parameters. Eldecalcitol also promoted focal bone formation independent of bone resorption, a process known as bone minimodeling. In clinical studies, eldecalcitol showed stronger effects than alfacalcidol in increasing BMD and reducing bone resorption markers in osteoporotic patients under vitamin D supplementation. A 3-year randomized, double-blind, active-comparator clinical trial demonstrated that once-daily 0.75 μg eldecalcitol reduced vertebral fracture incidence by 26% compared with 1.0 μg alfacalcidol. Eldecalcitol also reduced the incidence of wrist fractures by 71% compared with alfacalcidol. Although this may be due to the previously reported effect of vitamin D in reducing the incidence of falls, it is not known whether eldecalcitol has a stronger effect in preventing falls than alfacalcidol. Because eldecalcitol stimulates intestinal Ca absorption and improves Ca balance in addition to its skeletal effects, combination treatment with antiresorptive agents may be able to show better effects than native vitamin D and Ca supplementation in preventing fractures in osteoporotic patients. Further studies are warranted to clarify these issues." @default.
- W2016272508 created "2016-06-24" @default.
- W2016272508 creator A5004644505 @default.
- W2016272508 creator A5006884303 @default.
- W2016272508 creator A5042750898 @default.
- W2016272508 creator A5053905610 @default.
- W2016272508 date "2014-03-05" @default.
- W2016272508 modified "2023-09-25" @default.
- W2016272508 title "Vitamin D analogs and bone: preclinical and clinical studies with eldecalcitol" @default.
- W2016272508 cites W175660244 @default.
- W2016272508 cites W1970340431 @default.
- W2016272508 cites W1974366297 @default.
- W2016272508 cites W1974744779 @default.
- W2016272508 cites W1991817841 @default.
- W2016272508 cites W1997702262 @default.
- W2016272508 cites W1999438656 @default.
- W2016272508 cites W2046313856 @default.
- W2016272508 cites W2048873273 @default.
- W2016272508 cites W2051011991 @default.
- W2016272508 cites W2085397623 @default.
- W2016272508 cites W2085991781 @default.
- W2016272508 cites W2090155310 @default.
- W2016272508 cites W2092747552 @default.
- W2016272508 cites W2095158988 @default.
- W2016272508 cites W2098782984 @default.
- W2016272508 cites W2098843127 @default.
- W2016272508 cites W2118968952 @default.
- W2016272508 cites W2121926658 @default.
- W2016272508 cites W2139996507 @default.
- W2016272508 cites W2150399991 @default.
- W2016272508 cites W2949262009 @default.
- W2016272508 cites W2952111146 @default.
- W2016272508 doi "https://doi.org/10.1038/bonekey.2014.8" @default.
- W2016272508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4015458" @default.
- W2016272508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24818005" @default.
- W2016272508 hasPublicationYear "2014" @default.
- W2016272508 type Work @default.
- W2016272508 sameAs 2016272508 @default.
- W2016272508 citedByCount "17" @default.
- W2016272508 countsByYear W20162725082014 @default.
- W2016272508 countsByYear W20162725082015 @default.
- W2016272508 countsByYear W20162725082016 @default.
- W2016272508 countsByYear W20162725082017 @default.
- W2016272508 countsByYear W20162725082018 @default.
- W2016272508 countsByYear W20162725082020 @default.
- W2016272508 countsByYear W20162725082021 @default.
- W2016272508 countsByYear W20162725082022 @default.
- W2016272508 crossrefType "journal-article" @default.
- W2016272508 hasAuthorship W2016272508A5004644505 @default.
- W2016272508 hasAuthorship W2016272508A5006884303 @default.
- W2016272508 hasAuthorship W2016272508A5042750898 @default.
- W2016272508 hasAuthorship W2016272508A5053905610 @default.
- W2016272508 hasBestOaLocation W20162725082 @default.
- W2016272508 hasConcept C124490489 @default.
- W2016272508 hasConcept C126322002 @default.
- W2016272508 hasConcept C134018914 @default.
- W2016272508 hasConcept C170033053 @default.
- W2016272508 hasConcept C2776541429 @default.
- W2016272508 hasConcept C2776886416 @default.
- W2016272508 hasConcept C2779126354 @default.
- W2016272508 hasConcept C673006 @default.
- W2016272508 hasConcept C71924100 @default.
- W2016272508 hasConceptScore W2016272508C124490489 @default.
- W2016272508 hasConceptScore W2016272508C126322002 @default.
- W2016272508 hasConceptScore W2016272508C134018914 @default.
- W2016272508 hasConceptScore W2016272508C170033053 @default.
- W2016272508 hasConceptScore W2016272508C2776541429 @default.
- W2016272508 hasConceptScore W2016272508C2776886416 @default.
- W2016272508 hasConceptScore W2016272508C2779126354 @default.
- W2016272508 hasConceptScore W2016272508C673006 @default.
- W2016272508 hasConceptScore W2016272508C71924100 @default.
- W2016272508 hasLocation W20162725081 @default.
- W2016272508 hasLocation W20162725082 @default.
- W2016272508 hasLocation W20162725083 @default.
- W2016272508 hasLocation W20162725084 @default.
- W2016272508 hasOpenAccess W2016272508 @default.
- W2016272508 hasPrimaryLocation W20162725081 @default.
- W2016272508 hasRelatedWork W141873526 @default.
- W2016272508 hasRelatedWork W1967422973 @default.
- W2016272508 hasRelatedWork W2036148628 @default.
- W2016272508 hasRelatedWork W2041938128 @default.
- W2016272508 hasRelatedWork W2053638911 @default.
- W2016272508 hasRelatedWork W2105853087 @default.
- W2016272508 hasRelatedWork W2128714854 @default.
- W2016272508 hasRelatedWork W2160818938 @default.
- W2016272508 hasRelatedWork W2964737734 @default.
- W2016272508 hasRelatedWork W4384664112 @default.
- W2016272508 hasVolume "3" @default.
- W2016272508 isParatext "false" @default.
- W2016272508 isRetracted "false" @default.
- W2016272508 magId "2016272508" @default.
- W2016272508 workType "article" @default.