FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016273359> ?p ?o ?g. }

• W2016273359 endingPage "1120" @default.
• W2016273359 startingPage "1113" @default.
• W2016273359 abstract "1 As nonsteroidal antiinflammatory drugs may impair the ability of the chondrocyte to repair its damaged extracellular matrix, we explored the changes in the metabolism of newly synthesized proteoglycan (PG) and hyaluronan (HA) molecules produced by tenoxicam and aspirin in human normal cartilage explants and in osteoarthritic (OA) cartilage from age-matched donors. 2 Explants were sampled from the medial femoral condyle and were classified by use of Mankin's histological-histochemical grading system. Cartilage specimens were normal in 10 subjects, exhibited moderate OA (MOA) in 10 and had severe OA (SOA) in 10. 3 Cartilage explants were pulsed with [3H]-glucosamine and chased in the absence and in the presence of either aspirin (190 μg ml1) or tenoxicam (4–16 μg ml−1). After papain digestion, the labelled chondroitin sulphate ([3H]-PGs) and HA([3H]-HA) molecules present in the tissue and media were purified by anion-exchange chromatography. 4 In normal cartilage as well as in explants with MOA and SOA aspirin reduced more strongly PG and HA synthesis than the loss of [3H]-HA and [3H]-PGs. 5 In normal cartilage, tenoxicam did not affect PG metabolism whereas it reduced HA synthesis in a dose-dependent manner and did not change or even increased the net loss of [3H]-HA. In contrast, in OA cartilage, tenoxicam produced a stronger reduction in the loss of [3H]-PGs than in PG synthesis and this decrease occurred at lower concentrations in cartilage with SOA (4–8 μg ml−1) than in cartilage with MOA (8–16 μg ml−1). In cartilage with MOA, the metabolic balance of HA was unaffected by tenoxicam whereas in cartilage with SOA, the drug decreased the loss of [3H]-HA and concomitantly did not change or even increased HA synthesis. 6 The data obtained in short-term in vitro cultures indicate that aspirin may produce OA-like changes in normal cartilage and is likely to worsen the disease process in OA tissue. On the other hand, although tenoxicam may reduce the HA content of normal cartilage, and, in so doing, may produce OA-like lesions, this drug should not per se accelerate joint failure in OA." @default.
• W2016273359 created "2016-06-24" @default.
• W2016273359 creator A5011307330 @default.
• W2016273359 creator A5014539935 @default.
• W2016273359 creator A5040666538 @default.
• W2016273359 creator A5067149791 @default.
• W2016273359 date "1994-12-01" @default.
• W2016273359 modified "2023-10-16" @default.
• W2016273359 title "Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage" @default.
• W2016273359 cites W109534359 @default.
• W2016273359 cites W1484586689 @default.
• W2016273359 cites W1779148953 @default.
• W2016273359 cites W1967162929 @default.
• W2016273359 cites W1973184428 @default.
• W2016273359 cites W1973863566 @default.
• W2016273359 cites W1987234669 @default.
• W2016273359 cites W1994170360 @default.
• W2016273359 cites W1999652145 @default.
• W2016273359 cites W2007734100 @default.
• W2016273359 cites W2008428167 @default.
• W2016273359 cites W2013790334 @default.
• W2016273359 cites W2034462747 @default.
• W2016273359 cites W2040722050 @default.
• W2016273359 cites W206711978 @default.
• W2016273359 cites W2082966126 @default.
• W2016273359 cites W2125439396 @default.
• W2016273359 cites W2143429906 @default.
• W2016273359 cites W2412396561 @default.
• W2016273359 cites W2418156400 @default.
• W2016273359 cites W4292542165 @default.
• W2016273359 doi "https://doi.org/10.1111/j.1476-5381.1994.tb17111.x" @default.
• W2016273359 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1510488" @default.
• W2016273359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7889262" @default.
• W2016273359 hasPublicationYear "1994" @default.
• W2016273359 type Work @default.
• W2016273359 sameAs 2016273359 @default.
• W2016273359 citedByCount "16" @default.
• W2016273359 countsByYear W20162733592013 @default.
• W2016273359 countsByYear W20162733592015 @default.
• W2016273359 countsByYear W20162733592016 @default.
• W2016273359 countsByYear W20162733592019 @default.
• W2016273359 countsByYear W20162733592020 @default.
• W2016273359 countsByYear W20162733592022 @default.
• W2016273359 countsByYear W20162733592023 @default.
• W2016273359 crossrefType "journal-article" @default.
• W2016273359 hasAuthorship W2016273359A5011307330 @default.
• W2016273359 hasAuthorship W2016273359A5014539935 @default.
• W2016273359 hasAuthorship W2016273359A5040666538 @default.
• W2016273359 hasAuthorship W2016273359A5067149791 @default.
• W2016273359 hasBestOaLocation W20162733592 @default.
• W2016273359 hasConcept C105702510 @default.
• W2016273359 hasConcept C126322002 @default.
• W2016273359 hasConcept C134018914 @default.
• W2016273359 hasConcept C142724271 @default.
• W2016273359 hasConcept C185592680 @default.
• W2016273359 hasConcept C189165786 @default.
• W2016273359 hasConcept C204787440 @default.
• W2016273359 hasConcept C2776164576 @default.
• W2016273359 hasConcept C2777529286 @default.
• W2016273359 hasConcept C2778139025 @default.
• W2016273359 hasConcept C2778432687 @default.
• W2016273359 hasConcept C2779335624 @default.
• W2016273359 hasConcept C2780550940 @default.
• W2016273359 hasConcept C55493867 @default.
• W2016273359 hasConcept C71924100 @default.
• W2016273359 hasConceptScore W2016273359C105702510 @default.
• W2016273359 hasConceptScore W2016273359C126322002 @default.
• W2016273359 hasConceptScore W2016273359C134018914 @default.
• W2016273359 hasConceptScore W2016273359C142724271 @default.
• W2016273359 hasConceptScore W2016273359C185592680 @default.
• W2016273359 hasConceptScore W2016273359C189165786 @default.
• W2016273359 hasConceptScore W2016273359C204787440 @default.
• W2016273359 hasConceptScore W2016273359C2776164576 @default.
• W2016273359 hasConceptScore W2016273359C2777529286 @default.
• W2016273359 hasConceptScore W2016273359C2778139025 @default.
• W2016273359 hasConceptScore W2016273359C2778432687 @default.
• W2016273359 hasConceptScore W2016273359C2779335624 @default.
• W2016273359 hasConceptScore W2016273359C2780550940 @default.
• W2016273359 hasConceptScore W2016273359C55493867 @default.
• W2016273359 hasConceptScore W2016273359C71924100 @default.
• W2016273359 hasIssue "4" @default.
• W2016273359 hasLocation W20162733591 @default.
• W2016273359 hasLocation W20162733592 @default.
• W2016273359 hasLocation W20162733593 @default.
• W2016273359 hasLocation W20162733594 @default.
• W2016273359 hasOpenAccess W2016273359 @default.
• W2016273359 hasPrimaryLocation W20162733591 @default.
• W2016273359 hasRelatedWork W1965480501 @default.
• W2016273359 hasRelatedWork W1990800272 @default.
• W2016273359 hasRelatedWork W2045328719 @default.
• W2016273359 hasRelatedWork W2055448658 @default.
• W2016273359 hasRelatedWork W2073767477 @default.
• W2016273359 hasRelatedWork W2150523614 @default.
• W2016273359 hasRelatedWork W2162843941 @default.
• W2016273359 hasRelatedWork W2395811282 @default.
• W2016273359 hasRelatedWork W2417779650 @default.
• W2016273359 hasRelatedWork W2418927562 @default.
• W2016273359 hasVolume "113" @default.

• next