FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016274261> ?p ?o ?g. }

• W2016274261 endingPage "849" @default.
• W2016274261 startingPage "838" @default.
• W2016274261 abstract "Ovine placental lactogen is as reactive as human growth hormone with the human growth hormone receptor of cultured human (IM-9) lymphocytes, which confirms the findings of Carr and Friesen with receptors of human liver. We now also show that bovine and ovine growth hormones and ovine prolactin have reactivity for the human growth hormone receptor on IM-9 lymphocytes that is of the same order of magnitude (0.03%) as that previously reported for human placental lactogen. The binding studies predict that these non-primate hormones will have biological effects on skeletal growth in primates, either as agonists or antagonists. Previous studies have shown that when IM-9 lymphocytes are exposed to human growth hormone for 18 h at 37 C, there is a time and concentration dependent loss of human growth hormone receptors, and the magnitude of the loss of receptors after preincubation for 18 h at 37 C is greater than the average occupancy of receptors under steady state conditions for 90 min at 30 C. In the present study we show that human and ovine placental lactogens, ovine prolactin, and bovine and ovine growth hormones also produce this effect on the human growth hormone receptor. Since the cellular process by which a hormone induces loss of its own receptors appears to require binding of the hormone to its receptor as well as one or more subsequent steps in hormone action, it is likely that all of the preparations that induce receptor loss will be shown to have some agonist activity of human growth hormone in promoting skeletal growth in primates. Further, these studies extend the interrelationships between primate and non-primate pituitary and placental hormones from what has been suggested previously from biological and structural studies." @default.
• W2016274261 created "2016-06-24" @default.
• W2016274261 creator A5030380280 @default.
• W2016274261 creator A5070064147 @default.
• W2016274261 creator A5085932070 @default.
• W2016274261 date "1977-05-01" @default.
• W2016274261 modified "2023-10-14" @default.
• W2016274261 title "Reactivity of Non-Primate Growth Hormones and Prolactins with Human Growth Hormone Receptors on Cultured Human Lymphocytes" @default.
• W2016274261 cites W141312638 @default.
• W2016274261 cites W1491185682 @default.
• W2016274261 cites W162874501 @default.
• W2016274261 cites W1965263613 @default.
• W2016274261 cites W1966605057 @default.
• W2016274261 cites W1970638520 @default.
• W2016274261 cites W1973309749 @default.
• W2016274261 cites W1977990767 @default.
• W2016274261 cites W1980229029 @default.
• W2016274261 cites W1984376328 @default.
• W2016274261 cites W1991018590 @default.
• W2016274261 cites W1997342108 @default.
• W2016274261 cites W2007699005 @default.
• W2016274261 cites W2026358418 @default.
• W2016274261 cites W2037316432 @default.
• W2016274261 cites W2040093104 @default.
• W2016274261 cites W2044952013 @default.
• W2016274261 cites W2048602573 @default.
• W2016274261 cites W2048793124 @default.
• W2016274261 cites W2061148492 @default.
• W2016274261 cites W2080513099 @default.
• W2016274261 cites W2082358296 @default.
• W2016274261 cites W2091429317 @default.
• W2016274261 cites W2093699547 @default.
• W2016274261 cites W2135262279 @default.
• W2016274261 cites W2169736240 @default.
• W2016274261 doi "https://doi.org/10.1210/jcem-44-5-838" @default.
• W2016274261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/192753" @default.
• W2016274261 hasPublicationYear "1977" @default.
• W2016274261 type Work @default.
• W2016274261 sameAs 2016274261 @default.
• W2016274261 citedByCount "88" @default.
• W2016274261 crossrefType "journal-article" @default.
• W2016274261 hasAuthorship W2016274261A5030380280 @default.
• W2016274261 hasAuthorship W2016274261A5070064147 @default.
• W2016274261 hasAuthorship W2016274261A5085932070 @default.
• W2016274261 hasConcept C113675107 @default.
• W2016274261 hasConcept C121608353 @default.
• W2016274261 hasConcept C126322002 @default.
• W2016274261 hasConcept C134018914 @default.
• W2016274261 hasConcept C170493617 @default.
• W2016274261 hasConcept C172680121 @default.
• W2016274261 hasConcept C23589133 @default.
• W2016274261 hasConcept C2776953305 @default.
• W2016274261 hasConcept C2777064457 @default.
• W2016274261 hasConcept C2777675195 @default.
• W2016274261 hasConcept C2778938600 @default.
• W2016274261 hasConcept C2779064019 @default.
• W2016274261 hasConcept C2779234561 @default.
• W2016274261 hasConcept C2984496839 @default.
• W2016274261 hasConcept C530470458 @default.
• W2016274261 hasConcept C54355233 @default.
• W2016274261 hasConcept C71315377 @default.
• W2016274261 hasConcept C71924100 @default.
• W2016274261 hasConcept C86803240 @default.
• W2016274261 hasConceptScore W2016274261C113675107 @default.
• W2016274261 hasConceptScore W2016274261C121608353 @default.
• W2016274261 hasConceptScore W2016274261C126322002 @default.
• W2016274261 hasConceptScore W2016274261C134018914 @default.
• W2016274261 hasConceptScore W2016274261C170493617 @default.
• W2016274261 hasConceptScore W2016274261C172680121 @default.
• W2016274261 hasConceptScore W2016274261C23589133 @default.
• W2016274261 hasConceptScore W2016274261C2776953305 @default.
• W2016274261 hasConceptScore W2016274261C2777064457 @default.
• W2016274261 hasConceptScore W2016274261C2777675195 @default.
• W2016274261 hasConceptScore W2016274261C2778938600 @default.
• W2016274261 hasConceptScore W2016274261C2779064019 @default.
• W2016274261 hasConceptScore W2016274261C2779234561 @default.
• W2016274261 hasConceptScore W2016274261C2984496839 @default.
• W2016274261 hasConceptScore W2016274261C530470458 @default.
• W2016274261 hasConceptScore W2016274261C54355233 @default.
• W2016274261 hasConceptScore W2016274261C71315377 @default.
• W2016274261 hasConceptScore W2016274261C71924100 @default.
• W2016274261 hasConceptScore W2016274261C86803240 @default.
• W2016274261 hasIssue "5" @default.
• W2016274261 hasLocation W20162742611 @default.
• W2016274261 hasLocation W20162742612 @default.
• W2016274261 hasOpenAccess W2016274261 @default.
• W2016274261 hasPrimaryLocation W20162742611 @default.
• W2016274261 hasRelatedWork W1597151753 @default.
• W2016274261 hasRelatedWork W1972051303 @default.
• W2016274261 hasRelatedWork W1999154534 @default.
• W2016274261 hasRelatedWork W2010918548 @default.
• W2016274261 hasRelatedWork W2017068595 @default.
• W2016274261 hasRelatedWork W2018356368 @default.
• W2016274261 hasRelatedWork W2058205365 @default.
• W2016274261 hasRelatedWork W2094401363 @default.
• W2016274261 hasRelatedWork W2123270741 @default.
• W2016274261 hasRelatedWork W2417802249 @default.
• W2016274261 hasVolume "44" @default.

• next