FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016275989> ?p ?o ?g. }

• W2016275989 endingPage "1156" @default.
• W2016275989 startingPage "1146" @default.
• W2016275989 abstract "γ-Hydroxybutyric Acid (GHB) is thought to be a weak partial agonist at the γ-aminobutyric acidB Receptor (GABABR), but the precise relationship of the GHB receptor (GHBR) to the GABABR remains unclear. In order to test the hypothesis that the GHBR is not identical to the GABABR, we conducted two groups of experiments. First, GABABR subtype 1 (R1) and/or subtype 2 (R2) were over expressed in HEK 293 cells and membrane binding studies on the transfected cells done using [3H]GHB and [3H] (2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([3H]NCS-382). The latter is a specific antagonist at the GHB binding site. Second, [3H]GHB and [3H]NCS-382 autoradiographic binding studies were done on the brains of mice in which the gene for GABABR1a was deleted. Such mice do not have a functioning GABABR. There was no detectable specific [3H]GHB or [3H]NCS-382 binding in HEK 293 cells transfected with GABABR1, R2, or R1/R2. Binding to [3H]CGP54626A, a high affinity GABABR antagonist, was absent in GABABR1a−/− mice. There was no difference in [3H]NCS-382 binding observed in the brains of GABABR1a−/−, GABABR1a+/− or GABABR1a+/+ mice. Specific [3H]GHB binding was observed in the brain of GABABR1a−/− mice but was significantly lower than in wild type mice. These data support the hypothesis that the GHB binding site is separate and distinct from the GABABR." @default.
• W2016275989 created "2016-06-24" @default.
• W2016275989 creator A5000338259 @default.
• W2016275989 creator A5010982846 @default.
• W2016275989 creator A5019797356 @default.
• W2016275989 creator A5021077846 @default.
• W2016275989 creator A5026618924 @default.
• W2016275989 creator A5041640413 @default.
• W2016275989 creator A5047476496 @default.
• W2016275989 creator A5054904599 @default.
• W2016275989 creator A5074055562 @default.
• W2016275989 creator A5080330069 @default.
• W2016275989 date "2004-12-01" @default.
• W2016275989 modified "2023-10-16" @default.
• W2016275989 title "γ-Hydroxybutyric acid (GHB) and γ-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence" @default.
• W2016275989 cites W1654156243 @default.
• W2016275989 cites W1986584374 @default.
• W2016275989 cites W1996412351 @default.
• W2016275989 cites W2007446383 @default.
• W2016275989 cites W2007889607 @default.
• W2016275989 cites W2008345349 @default.
• W2016275989 cites W2016897045 @default.
• W2016275989 cites W2026968086 @default.
• W2016275989 cites W2032310869 @default.
• W2016275989 cites W2047149185 @default.
• W2016275989 cites W2060490717 @default.
• W2016275989 cites W2068134115 @default.
• W2016275989 cites W2072863696 @default.
• W2016275989 cites W2075720494 @default.
• W2016275989 cites W2076528772 @default.
• W2016275989 cites W2079128423 @default.
• W2016275989 cites W2079128619 @default.
• W2016275989 cites W2079475128 @default.
• W2016275989 cites W2083251993 @default.
• W2016275989 cites W2090278597 @default.
• W2016275989 cites W2095564883 @default.
• W2016275989 cites W2121297747 @default.
• W2016275989 cites W2124517960 @default.
• W2016275989 cites W2130262301 @default.
• W2016275989 cites W2133542906 @default.
• W2016275989 cites W2139578829 @default.
• W2016275989 cites W2144985457 @default.
• W2016275989 cites W2156277612 @default.
• W2016275989 cites W2157909194 @default.
• W2016275989 cites W2163874819 @default.
• W2016275989 cites W2165696259 @default.
• W2016275989 cites W2172001944 @default.
• W2016275989 doi "https://doi.org/10.1016/j.neuropharm.2004.08.019" @default.
• W2016275989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15567424" @default.
• W2016275989 hasPublicationYear "2004" @default.
• W2016275989 type Work @default.
• W2016275989 sameAs 2016275989 @default.
• W2016275989 citedByCount "56" @default.
• W2016275989 countsByYear W20162759892012 @default.
• W2016275989 countsByYear W20162759892013 @default.
• W2016275989 countsByYear W20162759892014 @default.
• W2016275989 countsByYear W20162759892015 @default.
• W2016275989 countsByYear W20162759892016 @default.
• W2016275989 countsByYear W20162759892017 @default.
• W2016275989 countsByYear W20162759892018 @default.
• W2016275989 countsByYear W20162759892019 @default.
• W2016275989 countsByYear W20162759892020 @default.
• W2016275989 countsByYear W20162759892021 @default.
• W2016275989 countsByYear W20162759892022 @default.
• W2016275989 crossrefType "journal-article" @default.
• W2016275989 hasAuthorship W2016275989A5000338259 @default.
• W2016275989 hasAuthorship W2016275989A5010982846 @default.
• W2016275989 hasAuthorship W2016275989A5019797356 @default.
• W2016275989 hasAuthorship W2016275989A5021077846 @default.
• W2016275989 hasAuthorship W2016275989A5026618924 @default.
• W2016275989 hasAuthorship W2016275989A5041640413 @default.
• W2016275989 hasAuthorship W2016275989A5047476496 @default.
• W2016275989 hasAuthorship W2016275989A5054904599 @default.
• W2016275989 hasAuthorship W2016275989A5074055562 @default.
• W2016275989 hasAuthorship W2016275989A5080330069 @default.
• W2016275989 hasConcept C104317684 @default.
• W2016275989 hasConcept C107824862 @default.
• W2016275989 hasConcept C170493617 @default.
• W2016275989 hasConcept C174510640 @default.
• W2016275989 hasConcept C185592680 @default.
• W2016275989 hasConcept C2776885963 @default.
• W2016275989 hasConcept C2778938600 @default.
• W2016275989 hasConcept C54009773 @default.
• W2016275989 hasConcept C55493867 @default.
• W2016275989 hasConcept C86803240 @default.
• W2016275989 hasConcept C98274493 @default.
• W2016275989 hasConceptScore W2016275989C104317684 @default.
• W2016275989 hasConceptScore W2016275989C107824862 @default.
• W2016275989 hasConceptScore W2016275989C170493617 @default.
• W2016275989 hasConceptScore W2016275989C174510640 @default.
• W2016275989 hasConceptScore W2016275989C185592680 @default.
• W2016275989 hasConceptScore W2016275989C2776885963 @default.
• W2016275989 hasConceptScore W2016275989C2778938600 @default.
• W2016275989 hasConceptScore W2016275989C54009773 @default.
• W2016275989 hasConceptScore W2016275989C55493867 @default.
• W2016275989 hasConceptScore W2016275989C86803240 @default.
• W2016275989 hasConceptScore W2016275989C98274493 @default.
• W2016275989 hasIssue "8" @default.

• next