Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016278281> ?p ?o ?g. }
- W2016278281 endingPage "1046" @default.
- W2016278281 startingPage "1039" @default.
- W2016278281 abstract "Factors contained in physiological microenvironments in tissues where mast cells differentiate and reside may influence mast cell responsiveness and modify antigen-dependent activation. A possible direct or indirect role of mast cell responses in diabetes mellitus prompted us to study the impact of insulin treatment on antigen triggered signaling pathways downstream of FcepsilonRI in bone marrow-derived mouse mast cells (BMMCs). We found that insulin alone stimulates tyrosine phosphorylation of tyrosine kinases Lyn, Syk, Fyn, the adapter protein Gab2 (Grb2-associated binding protein 2), Akt and activates ERK, JNK and p38 kinase. Effect of insulin on FcepsilonRI signaling pathways was marked by enhanced phosphorylation of Lyn, Fyn, Gab2 and Akt. Furthermore, BMMC stimulated with antigen in the presence of insulin responded with enhanced protein kinase theta (PKCtheta) activity and increased JNK phosphorylation when compared to BMMC triggered with antigen alone. Functional studies reveal enhanced degranulation and altered cytoskeletal rearrangement when BMMCs were treated simultaneously with insulin and antigen. Our results suggest that insulin tunes antigen-mediated responses of mast cells." @default.
- W2016278281 created "2016-06-24" @default.
- W2016278281 creator A5024871281 @default.
- W2016278281 creator A5056123723 @default.
- W2016278281 creator A5087215655 @default.
- W2016278281 date "2010-02-01" @default.
- W2016278281 modified "2023-09-27" @default.
- W2016278281 title "Insulin potentiates FcɛRI-mediated signaling in mouse bone marrow-derived mast cells" @default.
- W2016278281 cites W1481377618 @default.
- W2016278281 cites W1555637041 @default.
- W2016278281 cites W1589012667 @default.
- W2016278281 cites W1654498070 @default.
- W2016278281 cites W1773423646 @default.
- W2016278281 cites W1793329854 @default.
- W2016278281 cites W1807852583 @default.
- W2016278281 cites W1833006606 @default.
- W2016278281 cites W1866106776 @default.
- W2016278281 cites W1877871145 @default.
- W2016278281 cites W1930788232 @default.
- W2016278281 cites W1947575656 @default.
- W2016278281 cites W1966676304 @default.
- W2016278281 cites W1974241409 @default.
- W2016278281 cites W1974829480 @default.
- W2016278281 cites W1978243682 @default.
- W2016278281 cites W1980388991 @default.
- W2016278281 cites W1985051237 @default.
- W2016278281 cites W1993233738 @default.
- W2016278281 cites W1997257161 @default.
- W2016278281 cites W1999500196 @default.
- W2016278281 cites W2000648336 @default.
- W2016278281 cites W2000695809 @default.
- W2016278281 cites W2007124301 @default.
- W2016278281 cites W2012385196 @default.
- W2016278281 cites W2014887370 @default.
- W2016278281 cites W2015082452 @default.
- W2016278281 cites W2015651900 @default.
- W2016278281 cites W2017665872 @default.
- W2016278281 cites W2029631111 @default.
- W2016278281 cites W2029830646 @default.
- W2016278281 cites W2039516467 @default.
- W2016278281 cites W2044618871 @default.
- W2016278281 cites W2044919350 @default.
- W2016278281 cites W2045204290 @default.
- W2016278281 cites W2046860197 @default.
- W2016278281 cites W2050696396 @default.
- W2016278281 cites W2051953504 @default.
- W2016278281 cites W2053225881 @default.
- W2016278281 cites W2056899647 @default.
- W2016278281 cites W2059812320 @default.
- W2016278281 cites W2065375178 @default.
- W2016278281 cites W2076219754 @default.
- W2016278281 cites W2088195013 @default.
- W2016278281 cites W2088702765 @default.
- W2016278281 cites W2108352126 @default.
- W2016278281 cites W2111295274 @default.
- W2016278281 cites W2115177689 @default.
- W2016278281 cites W2119256134 @default.
- W2016278281 cites W2119630053 @default.
- W2016278281 cites W2128312073 @default.
- W2016278281 cites W2146157811 @default.
- W2016278281 cites W2147183697 @default.
- W2016278281 cites W2153469919 @default.
- W2016278281 cites W2154587917 @default.
- W2016278281 cites W2162696238 @default.
- W2016278281 cites W2162819143 @default.
- W2016278281 cites W2201960916 @default.
- W2016278281 cites W2226485247 @default.
- W2016278281 cites W2416844013 @default.
- W2016278281 cites W4238569697 @default.
- W2016278281 cites W4313146752 @default.
- W2016278281 doi "https://doi.org/10.1016/j.molimm.2009.11.013" @default.
- W2016278281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20004975" @default.
- W2016278281 hasPublicationYear "2010" @default.
- W2016278281 type Work @default.
- W2016278281 sameAs 2016278281 @default.
- W2016278281 citedByCount "12" @default.
- W2016278281 countsByYear W20162782812012 @default.
- W2016278281 countsByYear W20162782812015 @default.
- W2016278281 countsByYear W20162782812017 @default.
- W2016278281 countsByYear W20162782812019 @default.
- W2016278281 countsByYear W20162782812020 @default.
- W2016278281 countsByYear W20162782812021 @default.
- W2016278281 countsByYear W20162782812022 @default.
- W2016278281 crossrefType "journal-article" @default.
- W2016278281 hasAuthorship W2016278281A5024871281 @default.
- W2016278281 hasAuthorship W2016278281A5056123723 @default.
- W2016278281 hasAuthorship W2016278281A5087215655 @default.
- W2016278281 hasConcept C112446052 @default.
- W2016278281 hasConcept C11960822 @default.
- W2016278281 hasConcept C126322002 @default.
- W2016278281 hasConcept C134018914 @default.
- W2016278281 hasConcept C170493617 @default.
- W2016278281 hasConcept C175818844 @default.
- W2016278281 hasConcept C203014093 @default.
- W2016278281 hasConcept C2777391703 @default.
- W2016278281 hasConcept C2777553839 @default.
- W2016278281 hasConcept C2779306644 @default.
- W2016278281 hasConcept C2779726688 @default.