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• W2016278467 startingPage "1175" @default.
• W2016278467 abstract "The effects of aminoglutethimide (AG), metyrapone (MET), and ascorbic acid (AA) on the conversion of labeled cholesterol to testosterone (T) by the mature rat testis were examined and compared under identical in vitro conditions. In cell-free testicular homogenates, formation of labeled T from cholesterol-4-14C was depressed in a dose-related manner by AG and MET in concentrations ranging from 0.03 to 1.0 mM; AG was the more potent inhibitor at each concentration tested. Within this range of concentrations, AA induced a slight stimulation of the conversion of cholesterol-4-14C to T, with inhibition demonstrable only above 5.0 mM. Halfmaximal inhibition of T formation was attained with 0.1, 0.3, and 6.4 mM concentrations of AG, MET, and AA, respectively. When the synthesis of T was almost completely prevented by any of these agents, no accumulation of known intermediates between cholesterol and T could be demonstrated. Under these conditions, MET had no effect on the conversion of pregnenolone-4-14C to T or several T precursors or on the rate of metabolic degradation of testosterone-4-14C. Since the generation of the six-carbon fragment resulting from side chain cleavage of cholesterol-26-14C by rat testicular mitochondrial suspensions was also inhibited by AG, MET, and AA, the depression of steroid production affected by these agents in the testis appears to be related to their capacity to block the reaction cholesterol pregnenolone, as previously demonstrated in the adrenal and ovary. AG, MET, and AA thus inhibit cholesterol cleavage in adrenal and gonadal tissues as well as 11β-hydroxylation in the adrenal. In view of the similarities between the enzyme systems affected, it is likely that AG, MET, and AA exert their inhibitory effects on steroid-forming tissues through similar mechanisms." @default.
• W2016278467 created "2016-06-24" @default.
• W2016278467 creator A5052505718 @default.
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• W2016278467 date "1974-12-01" @default.
• W2016278467 modified "2023-10-13" @default.
• W2016278467 title "Effects of aminoglutethimide, metyrapone, and ascorbic acid on testicular metabolism of cholesterol" @default.
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• W2016278467 doi "https://doi.org/10.1016/0026-0495(74)90034-1" @default.
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• W2016278467 hasPublicationYear "1974" @default.
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