FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016278586> ?p ?o ?g. }

• W2016278586 endingPage "365" @default.
• W2016278586 startingPage "356" @default.
• W2016278586 abstract "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations. In the present study we have combined in situ hybridization for identifying spinal neurons that use the transmitter(s) glycine and/or GABA (Gly/GABA neurons) with immunohistochemistry for c-fos, a marker for neuronal activation. This procedure was used with acute pain models induced by the injection of capsaicin or formalin; and chronic pain models using Complete Freund's Adjuvant (CFA, chronic inflammation), and the spared nerve injury (SNI) model (neuropathic pain). In all models Gly/GABA neurons were activated as indicated by their expression of c-fos. The pattern of Gly/GABA neuronal activation was different for every model, both anatomically and quantitatively. However, the averaged percentage of activated neurons that were Gly/GABA in the chronic phase (≥20 h survival, 46%) was significantly higher than in the acute phase (≤2 h survival, 34%). In addition, the total numbers of activated Gly/GABA neurons were similar in both phases, showing that the activation of non-Gly/GABA (presumed excitatory) neurons in the chronic phase decreased. Finally, morphine application equally decreased the total number of activated neurons and activated Gly/GABA neurons. This showed that morphine did not specifically activate Gly/GABA neurons to achieve nociceptive inhibition. The present study shows an increased activity of Gly/GABA neurons in acute and chronic models. This mechanism, together with mechanisms that antagonize the effects of GABA and glycine at the receptor level, may determine the sensitivity of our pain system during health and disease." @default.
• W2016278586 created "2016-06-24" @default.
• W2016278586 creator A5006430043 @default.
• W2016278586 creator A5015706570 @default.
• W2016278586 creator A5045542659 @default.
• W2016278586 creator A5049008291 @default.
• W2016278586 creator A5067119673 @default.
• W2016278586 date "2010-11-01" @default.
• W2016278586 modified "2023-10-14" @default.
• W2016278586 title "Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models" @default.
• W2016278586 cites W1556754351 @default.
• W2016278586 cites W1567615855 @default.
• W2016278586 cites W1862870409 @default.
• W2016278586 cites W1945096581 @default.
• W2016278586 cites W1965781621 @default.
• W2016278586 cites W1968759033 @default.
• W2016278586 cites W1971721779 @default.
• W2016278586 cites W1979201750 @default.
• W2016278586 cites W1983852893 @default.
• W2016278586 cites W1988192071 @default.
• W2016278586 cites W1992680999 @default.
• W2016278586 cites W2000217423 @default.
• W2016278586 cites W2005405942 @default.
• W2016278586 cites W2009345240 @default.
• W2016278586 cites W2009960484 @default.
• W2016278586 cites W2011606970 @default.
• W2016278586 cites W2011831455 @default.
• W2016278586 cites W2013184793 @default.
• W2016278586 cites W2019299070 @default.
• W2016278586 cites W2020483119 @default.
• W2016278586 cites W2031203578 @default.
• W2016278586 cites W2033843602 @default.
• W2016278586 cites W2041272952 @default.
• W2016278586 cites W2044758709 @default.
• W2016278586 cites W2047010161 @default.
• W2016278586 cites W2047137871 @default.
• W2016278586 cites W2049879893 @default.
• W2016278586 cites W2054637122 @default.
• W2016278586 cites W2058687743 @default.
• W2016278586 cites W2059483820 @default.
• W2016278586 cites W2060890290 @default.
• W2016278586 cites W2060923069 @default.
• W2016278586 cites W2063223361 @default.
• W2016278586 cites W2063283818 @default.
• W2016278586 cites W2068420002 @default.
• W2016278586 cites W2079443803 @default.
• W2016278586 cites W2081927642 @default.
• W2016278586 cites W2084414231 @default.
• W2016278586 cites W2092239347 @default.
• W2016278586 cites W2092246706 @default.
• W2016278586 cites W2105769803 @default.
• W2016278586 cites W2107011563 @default.
• W2016278586 cites W2110779632 @default.
• W2016278586 cites W2127300695 @default.
• W2016278586 cites W2128994172 @default.
• W2016278586 cites W2132829674 @default.
• W2016278586 cites W2146840152 @default.
• W2016278586 cites W2147948348 @default.
• W2016278586 cites W2155524482 @default.
• W2016278586 cites W2156414729 @default.
• W2016278586 cites W2159457729 @default.
• W2016278586 cites W2161165456 @default.
• W2016278586 cites W2164333230 @default.
• W2016278586 doi "https://doi.org/10.1016/j.pain.2010.07.023" @default.
• W2016278586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20727678" @default.
• W2016278586 hasPublicationYear "2010" @default.
• W2016278586 type Work @default.
• W2016278586 sameAs 2016278586 @default.
• W2016278586 citedByCount "31" @default.
• W2016278586 countsByYear W20162785862012 @default.
• W2016278586 countsByYear W20162785862013 @default.
• W2016278586 countsByYear W20162785862014 @default.
• W2016278586 countsByYear W20162785862015 @default.
• W2016278586 countsByYear W20162785862016 @default.
• W2016278586 countsByYear W20162785862017 @default.
• W2016278586 countsByYear W20162785862018 @default.
• W2016278586 countsByYear W20162785862019 @default.
• W2016278586 countsByYear W20162785862020 @default.
• W2016278586 countsByYear W20162785862023 @default.
• W2016278586 crossrefType "journal-article" @default.
• W2016278586 hasAuthorship W2016278586A5006430043 @default.
• W2016278586 hasAuthorship W2016278586A5015706570 @default.
• W2016278586 hasAuthorship W2016278586A5045542659 @default.
• W2016278586 hasAuthorship W2016278586A5049008291 @default.
• W2016278586 hasAuthorship W2016278586A5067119673 @default.
• W2016278586 hasConcept C126322002 @default.
• W2016278586 hasConcept C15490471 @default.
• W2016278586 hasConcept C169760540 @default.
• W2016278586 hasConcept C170493617 @default.
• W2016278586 hasConcept C17077164 @default.
• W2016278586 hasConcept C185592680 @default.
• W2016278586 hasConcept C2777389121 @default.
• W2016278586 hasConcept C2777756961 @default.
• W2016278586 hasConcept C2780775167 @default.
• W2016278586 hasConcept C2781118164 @default.
• W2016278586 hasConcept C35599011 @default.
• W2016278586 hasConcept C515207424 @default.
• W2016278586 hasConcept C55493867 @default.

• next