FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016281075> ?p ?o ?g. }

• W2016281075 endingPage "175" @default.
• W2016281075 startingPage "163" @default.
• W2016281075 abstract "Mitogen driven differentiation of normal human mononuclear cells is a well-established model for the study of antibody synthesis in man. In certain rare individuals who are clinically normal, unfractionated mononuclear cells or a mixture of purified B plus T lymphocytes differentiate into immunoglobulin producing cells in response to purified protein derivative of tuberculin (PPD) but not in response to pokeweed mitogen (PWM). To evaluate this observation we have irradiated T cells from such individuals to eliminate naturally occurring suppressor T cell activity and then added the irradiated T cells back to autologous B cells before culture. The B cells then responded to PWM. The original PPD responses of cells from these individuals were now significantly reduced. Although, there was no difference between PWM nonresponders and responders in the number of OKT-8 positive cells, elimination of OKT-8 positive cells in the PWM nonresponders with OKT-8 monoclonal antibody and complement resulted in a significantly increased response to PWM. This study indicates that there are suppressor T cells which specifically inhibit B cell response to PWM without affecting the PPD response. These results also show that the helper T cells involved in the PWM response are radioresistant and those involved in the PPD response are radiosensitive." @default.
• W2016281075 created "2016-06-24" @default.
• W2016281075 creator A5082044280 @default.
• W2016281075 creator A5084626313 @default.
• W2016281075 creator A5085544047 @default.
• W2016281075 date "1983-07-01" @default.
• W2016281075 modified "2023-09-26" @default.
• W2016281075 title "Subpopulations of human helper and suppressor T lymphocytes" @default.
• W2016281075 cites W1480119587 @default.
• W2016281075 cites W1488329272 @default.
• W2016281075 cites W1498874223 @default.
• W2016281075 cites W1541103016 @default.
• W2016281075 cites W1558272088 @default.
• W2016281075 cites W1571911874 @default.
• W2016281075 cites W1572905821 @default.
• W2016281075 cites W1906656430 @default.
• W2016281075 cites W1968509506 @default.
• W2016281075 cites W1984864942 @default.
• W2016281075 cites W1999675694 @default.
• W2016281075 cites W2053776647 @default.
• W2016281075 cites W2056280614 @default.
• W2016281075 cites W2060248408 @default.
• W2016281075 cites W2126935456 @default.
• W2016281075 cites W2129025733 @default.
• W2016281075 cites W2129983985 @default.
• W2016281075 cites W2132295926 @default.
• W2016281075 cites W2141155302 @default.
• W2016281075 cites W2160274453 @default.
• W2016281075 cites W2415714411 @default.
• W2016281075 cites W4313305954 @default.
• W2016281075 cites W4313310042 @default.
• W2016281075 cites W4313340658 @default.
• W2016281075 doi "https://doi.org/10.1016/s0198-8859(83)80004-4" @default.
• W2016281075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6223904" @default.
• W2016281075 hasPublicationYear "1983" @default.
• W2016281075 type Work @default.
• W2016281075 sameAs 2016281075 @default.
• W2016281075 citedByCount "7" @default.
• W2016281075 crossrefType "journal-article" @default.
• W2016281075 hasAuthorship W2016281075A5082044280 @default.
• W2016281075 hasAuthorship W2016281075A5084626313 @default.
• W2016281075 hasAuthorship W2016281075A5085544047 @default.
• W2016281075 hasConcept C121608353 @default.
• W2016281075 hasConcept C126322002 @default.
• W2016281075 hasConcept C137061746 @default.
• W2016281075 hasConcept C153911025 @default.
• W2016281075 hasConcept C159654299 @default.
• W2016281075 hasConcept C179185449 @default.
• W2016281075 hasConcept C202751555 @default.
• W2016281075 hasConcept C203014093 @default.
• W2016281075 hasConcept C2776090121 @default.
• W2016281075 hasConcept C2781005381 @default.
• W2016281075 hasConcept C3018913218 @default.
• W2016281075 hasConcept C542903549 @default.
• W2016281075 hasConcept C54355233 @default.
• W2016281075 hasConcept C55493867 @default.
• W2016281075 hasConcept C58962609 @default.
• W2016281075 hasConcept C71924100 @default.
• W2016281075 hasConcept C81885089 @default.
• W2016281075 hasConcept C86803240 @default.
• W2016281075 hasConcept C8891405 @default.
• W2016281075 hasConceptScore W2016281075C121608353 @default.
• W2016281075 hasConceptScore W2016281075C126322002 @default.
• W2016281075 hasConceptScore W2016281075C137061746 @default.
• W2016281075 hasConceptScore W2016281075C153911025 @default.
• W2016281075 hasConceptScore W2016281075C159654299 @default.
• W2016281075 hasConceptScore W2016281075C179185449 @default.
• W2016281075 hasConceptScore W2016281075C202751555 @default.
• W2016281075 hasConceptScore W2016281075C203014093 @default.
• W2016281075 hasConceptScore W2016281075C2776090121 @default.
• W2016281075 hasConceptScore W2016281075C2781005381 @default.
• W2016281075 hasConceptScore W2016281075C3018913218 @default.
• W2016281075 hasConceptScore W2016281075C542903549 @default.
• W2016281075 hasConceptScore W2016281075C54355233 @default.
• W2016281075 hasConceptScore W2016281075C55493867 @default.
• W2016281075 hasConceptScore W2016281075C58962609 @default.
• W2016281075 hasConceptScore W2016281075C71924100 @default.
• W2016281075 hasConceptScore W2016281075C81885089 @default.
• W2016281075 hasConceptScore W2016281075C86803240 @default.
• W2016281075 hasConceptScore W2016281075C8891405 @default.
• W2016281075 hasIssue "3" @default.
• W2016281075 hasLocation W20162810751 @default.
• W2016281075 hasLocation W20162810752 @default.
• W2016281075 hasOpenAccess W2016281075 @default.
• W2016281075 hasPrimaryLocation W20162810751 @default.
• W2016281075 hasRelatedWork W1594562694 @default.
• W2016281075 hasRelatedWork W1992169430 @default.
• W2016281075 hasRelatedWork W2009889818 @default.
• W2016281075 hasRelatedWork W2016281075 @default.
• W2016281075 hasRelatedWork W2368460920 @default.
• W2016281075 hasRelatedWork W2380360044 @default.
• W2016281075 hasRelatedWork W2403656428 @default.
• W2016281075 hasRelatedWork W2408281465 @default.
• W2016281075 hasRelatedWork W2420090360 @default.
• W2016281075 hasRelatedWork W66877655 @default.
• W2016281075 hasVolume "7" @default.
• W2016281075 isParatext "false" @default.
• W2016281075 isRetracted "false" @default.

• next