FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016282258> ?p ?o ?g. }

• W2016282258 endingPage "16" @default.
• W2016282258 startingPage "1" @default.
• W2016282258 abstract "We have developed an in vitro model in which cells responding to trauma in the immature and mature CNS can be isolated, placed into serum-free culture, and characterized. By implanting nitrocellulose filters into the brains of neonatal and adult rats under different conditions, we are able to harvest populations of cells responding to trauma in the neonate (critical period implant), in the adult (scar implant), and in implants that have remained in vivo past the critical period (postcritical period implant). Upon placement in culture, we have found that astrocytes represent the majority of cells occupying both the critical period and postcritical period implants, whereas fibroblasts and macrophages represent the majority of cells in the glial-fibroblastic scar. The morphologies of the astrocytes on the surface of the different implants, after 3 days in culture, differs markedly—the critical period astrocytes exhibiting a more ordered distribution compared to the haphazard arrangement of astrocyte processes on the surface of the postcritical and scar implants. After migration from the implant, critical period astrocytes assume an epithelioid morphology and cluster together setting up definite boundaries between themselves and the endothelial cells. In contrast, postcritical period astrocytes exhibit a more elongated morphology under the same culture conditions and appear to be randomly dispersed among the endothelial cells. The scar astrocytes exhibit a wide range of morphologies and, although they tend to cluster, do not exhibit the ordered association seen with the critical period astrocytes. We propose that the plasticity of the neonatal astrocytes and the rapid and ordered cellular response seen in vitro reflect the ability of the immature CNS in vivo to respond to injury without the formation of a glial-fibroblastic scar." @default.
• W2016282258 created "2016-06-24" @default.
• W2016282258 creator A5058981154 @default.
• W2016282258 date "1989-01-01" @default.
• W2016282258 modified "2023-10-18" @default.
• W2016282258 title "An in vitro model of wound healing in the CNS: Analysis of cell reaction and interaction at different ages" @default.
• W2016282258 cites W11898488 @default.
• W2016282258 cites W1530612865 @default.
• W2016282258 cites W1550160699 @default.
• W2016282258 cites W1571209082 @default.
• W2016282258 cites W1571254150 @default.
• W2016282258 cites W1592789336 @default.
• W2016282258 cites W1646206347 @default.
• W2016282258 cites W1707282766 @default.
• W2016282258 cites W1909700132 @default.
• W2016282258 cites W1915958226 @default.
• W2016282258 cites W1929147662 @default.
• W2016282258 cites W1939198520 @default.
• W2016282258 cites W1961175455 @default.
• W2016282258 cites W1980265444 @default.
• W2016282258 cites W1984218330 @default.
• W2016282258 cites W1987577484 @default.
• W2016282258 cites W1989976594 @default.
• W2016282258 cites W1996133944 @default.
• W2016282258 cites W2010648680 @default.
• W2016282258 cites W2015358657 @default.
• W2016282258 cites W2017347652 @default.
• W2016282258 cites W2023402827 @default.
• W2016282258 cites W2035064612 @default.
• W2016282258 cites W2040524193 @default.
• W2016282258 cites W2051383504 @default.
• W2016282258 cites W2051393924 @default.
• W2016282258 cites W2053623203 @default.
• W2016282258 cites W2066117260 @default.
• W2016282258 cites W2068384471 @default.
• W2016282258 cites W2085216816 @default.
• W2016282258 cites W2093064749 @default.
• W2016282258 cites W2094954632 @default.
• W2016282258 cites W2095225284 @default.
• W2016282258 cites W2095869647 @default.
• W2016282258 cites W2098400443 @default.
• W2016282258 cites W2114918609 @default.
• W2016282258 cites W2123523845 @default.
• W2016282258 cites W2147064870 @default.
• W2016282258 cites W2151241124 @default.
• W2016282258 cites W2159746265 @default.
• W2016282258 cites W2161154195 @default.
• W2016282258 cites W2218403526 @default.
• W2016282258 cites W223795620 @default.
• W2016282258 cites W2401278782 @default.
• W2016282258 cites W2404886246 @default.
• W2016282258 cites W2468800676 @default.
• W2016282258 cites W2502637485 @default.
• W2016282258 cites W2504567802 @default.
• W2016282258 cites W51309640 @default.
• W2016282258 cites W982024992 @default.
• W2016282258 doi "https://doi.org/10.1016/0014-4886(89)90180-5" @default.
• W2016282258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2912745" @default.
• W2016282258 hasPublicationYear "1989" @default.
• W2016282258 type Work @default.
• W2016282258 sameAs 2016282258 @default.
• W2016282258 citedByCount "84" @default.
• W2016282258 countsByYear W20162822582014 @default.
• W2016282258 countsByYear W20162822582022 @default.
• W2016282258 crossrefType "journal-article" @default.
• W2016282258 hasAuthorship W2016282258A5058981154 @default.
• W2016282258 hasConcept C121332964 @default.
• W2016282258 hasConcept C141071460 @default.
• W2016282258 hasConcept C142724271 @default.
• W2016282258 hasConcept C169760540 @default.
• W2016282258 hasConcept C202751555 @default.
• W2016282258 hasConcept C203014093 @default.
• W2016282258 hasConcept C24890656 @default.
• W2016282258 hasConcept C2777542381 @default.
• W2016282258 hasConcept C2777594495 @default.
• W2016282258 hasConcept C2780269544 @default.
• W2016282258 hasConcept C2781291010 @default.
• W2016282258 hasConcept C2781411149 @default.
• W2016282258 hasConcept C529278444 @default.
• W2016282258 hasConcept C55493867 @default.
• W2016282258 hasConcept C71924100 @default.
• W2016282258 hasConcept C86803240 @default.
• W2016282258 hasConcept C95444343 @default.
• W2016282258 hasConceptScore W2016282258C121332964 @default.
• W2016282258 hasConceptScore W2016282258C141071460 @default.
• W2016282258 hasConceptScore W2016282258C142724271 @default.
• W2016282258 hasConceptScore W2016282258C169760540 @default.
• W2016282258 hasConceptScore W2016282258C202751555 @default.
• W2016282258 hasConceptScore W2016282258C203014093 @default.
• W2016282258 hasConceptScore W2016282258C24890656 @default.
• W2016282258 hasConceptScore W2016282258C2777542381 @default.
• W2016282258 hasConceptScore W2016282258C2777594495 @default.
• W2016282258 hasConceptScore W2016282258C2780269544 @default.
• W2016282258 hasConceptScore W2016282258C2781291010 @default.
• W2016282258 hasConceptScore W2016282258C2781411149 @default.
• W2016282258 hasConceptScore W2016282258C529278444 @default.
• W2016282258 hasConceptScore W2016282258C55493867 @default.
• W2016282258 hasConceptScore W2016282258C71924100 @default.

• next