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- W2016283224 abstract "ABSTRACT Since development of optogenetic stimulation paradigm, there has been several attempts to red shift the excitation maximum of the efficient blue-sensitive opsins. While there has been some success at the cost of altered light-activation kinetics, near-infrared optogenetic probe will be ideal for in-depth cell-specific stimulation of excitable cells in an organ. However, single-photon near-infrared optogenetics based stimulation will still limit precise probing and modulation of in-vivo neural circuits. In contrast, by virtue of non-linear nature of ultrafast light-matter interaction, high spatial precision in optogenetic activation can be achieved in addition to inherent cellular specificity and temporal resolution provided by the opsins. Here, we report use of non-linear optogenetics for stimulation of neurons in-vivo in mouse models. Advantage of using non-linear optogenetics for probing neuronal circuitry is discussed. Further, effectiveness of the non-diffracting optogenetic Bessel beam over classical Gaussian beam in a layered mouse-brain geometry is demonstrated using Monte Carlo (MC) simulation. This is corroborated by electrophysiological measurements in in-vivo mouse models. The large propagation distance, characteristics of Bessel beam is better suited for in-depth single as well as two-photon optogenetic stimulation. Key words: Optogenetics, near-infrared stimulation, non-linear optogenetics, Bessel beam, deep brain stimulation." @default.
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- W2016283224 date "2012-02-03" @default.
- W2016283224 modified "2023-09-27" @default.
- W2016283224 title "Shining new light on optogenetics" @default.
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- W2016283224 doi "https://doi.org/10.1117/12.916750" @default.
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