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- W2016284077 abstract "Abstract In order to identify biological processes relevant for cell death and survival in the brain following stroke, the postischemic brain transcriptome was studied by a large‐scale cDNA array analysis of three peri‐infarct brain regions at eight time points during the first 24 h of reperfusion following middle cerebral artery occlusion in the rat. K ‐means cluster analysis revealed two distinct biphasic gene expression patterns that contained 44 genes (including 18 immediate early genes), involved in cell signaling and plasticity (i.e. MAP2K7 , Sprouty2 , Irs‐2 , Homer1 , GPRC5B , Grasp ). The first gene induction phase occurred at 0–3 h of reperfusion, and the second at 9–15 h, and was validated by in situ hybridization. Four gene clusters displayed a progressive increase in expression over time and included 50 genes linked to cell motility, lipid synthesis and trafficking (i.e. ApoD , NPC1 , G3P‐dehydrogenase1 , and Choline kinase ) or cell death‐regulating genes such as mitochondrial CLIC . We conclude that a biphasic transcriptional up‐regulation of the brain‐derived neurotrophic factor (BDNF)–G‐protein coupled receptor (GPCR)–mitogen‐activated protein (MAP) kinase signaling pathways occurs in surviving tissue, concomitant with a progressive and persistent activation of cell proliferation signifying tissue regeneration, which provide the means for cell survival and postischemic brain plasticity." @default.
- W2016284077 created "2016-06-24" @default.
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- W2016284077 date "2005-11-21" @default.
- W2016284077 modified "2023-10-15" @default.
- W2016284077 title "Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue" @default.
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