FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016286002> ?p ?o ?g. }

• W2016286002 endingPage "S255" @default.
• W2016286002 startingPage "S254" @default.
• W2016286002 abstract "Purpose/Objective: The benefit of postoperative radiotherapy for glioma patients has been well established where an improvement in median survival was found with increased radiation dose. Dose from external beam radiotherapy is limited by normal brain toxicity. Brachytherapy can deliver higher radiation doses contained within short distance beyond resected tumor cavity wall. However, implants with traditional solid sources require a second invasive procedure, and often fail to tailor the dose distribution to individual target volume. One novel approach is to use radiolabeled target molecules to penetrate and deliver localized radiation to the tumor cells. TM-601 (also called chlorotoxin, TransMolecular, Inc. Birmingham, AL) is a peptide derived from the venom of the scorpion Leiurus Quinquestriatus that specifically binds to malignant brain tumors, but not to normal brain tissue. I-131-TM-601 provides an opportunity for synergy between radiotherapy and biotherapy. Phase I/II human clinical trials are on going, with 10 mCi of I-131-TM-601 directly infused into the resected tumor cavity. This study reports dosimetry results of I-131-TM-601 in athymic nude mice with intracranially implanted human glioma xenografts and projected doses in patients receiving I-131-TM-601. Materials/Methods: Fifteen days post implantation of U251MG xenografts in right brain, about 60 uCi of I-131-TM-601 were injected into brains of the mice, which were sacrificed 24–72 hour later. The blood, normal organs, and tumors were removed, weighed, and counted in a gamma counter to determine I-131-TM-601 concentration in each tissue. Mean cumulated activities per unit mass per injected dose (uCi-hr/g-uCi) were determined by integrating area under the time activity curve within 72 hours. The radiation dose from I-131 was predominated by non-penetrating radiation in the mouse model. Marrow radiation was determined based on I-131 concentration in the blood. Assuming similar tissue uptake of I-131-TM-601 in mice and patients, radiation doses for patients were also projected using Medical Internal Radiation Dose (MIRD) formalism. Results: Survival rate was substantially improved in glioma-bearing mice receiving I-131-TM-601 compared to that of saline or unlabeled TM601-treated (control) groups. Radiation doses to 10 major organs were examined. Mean radiation dose per unit activity injection (cGy/uCi) was 64.2 for tumor, 9.8 for right brain, 7.7 for left brain, 2.2 for marrow, 5.8 for heart, 0.9 for lungs, 20.3 for stomach, 12.4 for small intestine, 11.7 for spleen, 2.4 for kidneys, 1.0 for liver, and 1.2 for thyroid. Projected radiation dose per unit activity injection (cGy/mCi) for patients was 140 for 5mm tumor cavity wall, 2.7 for right brain, 2.1 for left brain, 0.8 for marrow, 2.0 for heart, 0.2 for lungs, 8.8 for stomach, 6.4 for small intestine, 2.3 for spleen, 2.3 for kidneys, 0.6 for liver, and 6.2 for thyroid. Patient doses can be reduced substantially using non-radioactive iodine solution to protect the thyroid, and using fluid to dilute the stomach content. Conclusions: I-131-TM-601 has a very high tumor dose-to-normal tissue index. The dosimetry data suggest that greater than 100 mCi of I-131-TM-601 can be safely administrated to patients. These promising results demonstrated great potential in improving patient survival using this novel target molecule." @default.
• W2016286002 created "2016-06-24" @default.
• W2016286002 creator A5042038442 @default.
• W2016286002 creator A5047996868 @default.
• W2016286002 creator A5059680487 @default.
• W2016286002 creator A5065852269 @default.
• W2016286002 date "2003-10-01" @default.
• W2016286002 modified "2023-10-16" @default.
• W2016286002 title "Radiation dosimetry of I-131- TM-601 peptide for synergistic targeted radiotherapy for malignant glioma in mice" @default.
• W2016286002 doi "https://doi.org/10.1016/s0360-3016(03)01090-3" @default.
• W2016286002 hasPublicationYear "2003" @default.
• W2016286002 type Work @default.
• W2016286002 sameAs 2016286002 @default.
• W2016286002 citedByCount "1" @default.
• W2016286002 crossrefType "journal-article" @default.
• W2016286002 hasAuthorship W2016286002A5042038442 @default.
• W2016286002 hasAuthorship W2016286002A5047996868 @default.
• W2016286002 hasAuthorship W2016286002A5059680487 @default.
• W2016286002 hasAuthorship W2016286002A5065852269 @default.
• W2016286002 hasBestOaLocation W20162860021 @default.
• W2016286002 hasConcept C126838900 @default.
• W2016286002 hasConcept C142724271 @default.
• W2016286002 hasConcept C150903083 @default.
• W2016286002 hasConcept C207001950 @default.
• W2016286002 hasConcept C2775908122 @default.
• W2016286002 hasConcept C2777416452 @default.
• W2016286002 hasConcept C2778227246 @default.
• W2016286002 hasConcept C2779130545 @default.
• W2016286002 hasConcept C2989005 @default.
• W2016286002 hasConcept C502942594 @default.
• W2016286002 hasConcept C509974204 @default.
• W2016286002 hasConcept C71924100 @default.
• W2016286002 hasConcept C75088862 @default.
• W2016286002 hasConcept C86803240 @default.
• W2016286002 hasConceptScore W2016286002C126838900 @default.
• W2016286002 hasConceptScore W2016286002C142724271 @default.
• W2016286002 hasConceptScore W2016286002C150903083 @default.
• W2016286002 hasConceptScore W2016286002C207001950 @default.
• W2016286002 hasConceptScore W2016286002C2775908122 @default.
• W2016286002 hasConceptScore W2016286002C2777416452 @default.
• W2016286002 hasConceptScore W2016286002C2778227246 @default.
• W2016286002 hasConceptScore W2016286002C2779130545 @default.
• W2016286002 hasConceptScore W2016286002C2989005 @default.
• W2016286002 hasConceptScore W2016286002C502942594 @default.
• W2016286002 hasConceptScore W2016286002C509974204 @default.
• W2016286002 hasConceptScore W2016286002C71924100 @default.
• W2016286002 hasConceptScore W2016286002C75088862 @default.
• W2016286002 hasConceptScore W2016286002C86803240 @default.
• W2016286002 hasIssue "2" @default.
• W2016286002 hasLocation W20162860021 @default.
• W2016286002 hasOpenAccess W2016286002 @default.
• W2016286002 hasPrimaryLocation W20162860021 @default.
• W2016286002 hasRelatedWork W1966226622 @default.
• W2016286002 hasRelatedWork W2043597413 @default.
• W2016286002 hasRelatedWork W2513916013 @default.
• W2016286002 hasRelatedWork W2760637598 @default.
• W2016286002 hasRelatedWork W2788839829 @default.
• W2016286002 hasRelatedWork W2966036943 @default.
• W2016286002 hasRelatedWork W3029484986 @default.
• W2016286002 hasRelatedWork W3107045007 @default.
• W2016286002 hasRelatedWork W4206581437 @default.
• W2016286002 hasRelatedWork W4237106564 @default.
• W2016286002 hasVolume "57" @default.
• W2016286002 isParatext "false" @default.
• W2016286002 isRetracted "false" @default.
• W2016286002 magId "2016286002" @default.
• W2016286002 workType "article" @default.