Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016288300> ?p ?o ?g. }
- W2016288300 endingPage "e51700" @default.
- W2016288300 startingPage "e51700" @default.
- W2016288300 abstract "The Dlx and Msx homeodomain transcription factors play important roles in the control of limb development. The combined disruption of Msx1 and Msx2, as well as that of Dlx5 and Dlx6, lead to limb patterning defects with anomalies in digit number and shape. Msx1;Msx2 double mutants are characterized by the loss of derivatives of the anterior limb mesoderm which is not observed in either of the simple mutants. Dlx5;Dlx6 double mutants exhibit hindlimb ectrodactyly. While the morphogenetic action of Msx genes seems to involve the BMP molecules, the mode of action of Dlx genes still remains elusive. Here, examining the limb phenotypes of combined Dlx and Msx mutants we reveal a new Dlx-Msx regulatory loop directly involving BMPs. In Msx1;Dlx5;Dlx6 triple mutant mice (TKO), beside the expected ectrodactyly, we also observe the hallmark morphological anomalies of Msx1;Msx2 double mutants suggesting an epistatic role of Dlx5 and Dlx6 over Msx2. In Msx2;Dlx5;Dlx6 TKO mice we only observe an aggravation of the ectrodactyly defect without changes in the number of the individual components of the limb. Using a combination of qPCR, ChIP and bioinformatic analyses, we identify two Dlx/Msx regulatory pathways: 1) in the anterior limb mesoderm a non-cell autonomous Msx-Dlx regulatory loop involves BMP molecules through the AER and 2) in AER cells and, at later stages, in the limb mesoderm the regulation of Msx2 by Dlx5 and Dlx6 occurs also cell autonomously. These data bring new elements to decipher the complex AER-mesoderm dialogue that takes place during limb development and provide clues to understanding the etiology of congenital limb malformations." @default.
- W2016288300 created "2016-06-24" @default.
- W2016288300 creator A5003197031 @default.
- W2016288300 creator A5006078322 @default.
- W2016288300 creator A5007883159 @default.
- W2016288300 creator A5018596153 @default.
- W2016288300 creator A5035753887 @default.
- W2016288300 creator A5037181302 @default.
- W2016288300 creator A5037981609 @default.
- W2016288300 creator A5042622817 @default.
- W2016288300 creator A5043459030 @default.
- W2016288300 creator A5052374213 @default.
- W2016288300 creator A5063120064 @default.
- W2016288300 creator A5073977322 @default.
- W2016288300 creator A5074658493 @default.
- W2016288300 creator A5086624610 @default.
- W2016288300 date "2013-01-29" @default.
- W2016288300 modified "2023-10-15" @default.
- W2016288300 title "BMP-Mediated Functional Cooperation between Dlx5;Dlx6 and Msx1;Msx2 during Mammalian Limb Development" @default.
- W2016288300 cites W1480928262 @default.
- W2016288300 cites W1494393295 @default.
- W2016288300 cites W1541819796 @default.
- W2016288300 cites W1565817365 @default.
- W2016288300 cites W1602845636 @default.
- W2016288300 cites W1616421194 @default.
- W2016288300 cites W1750082824 @default.
- W2016288300 cites W1947231608 @default.
- W2016288300 cites W1963641861 @default.
- W2016288300 cites W1965208797 @default.
- W2016288300 cites W1965998289 @default.
- W2016288300 cites W1967046291 @default.
- W2016288300 cites W1967380741 @default.
- W2016288300 cites W1971242931 @default.
- W2016288300 cites W1973566124 @default.
- W2016288300 cites W1976988264 @default.
- W2016288300 cites W1977518651 @default.
- W2016288300 cites W1978773012 @default.
- W2016288300 cites W1982404120 @default.
- W2016288300 cites W1982705391 @default.
- W2016288300 cites W1987113787 @default.
- W2016288300 cites W1998880332 @default.
- W2016288300 cites W2000048706 @default.
- W2016288300 cites W2001891435 @default.
- W2016288300 cites W2002391499 @default.
- W2016288300 cites W2002662423 @default.
- W2016288300 cites W2003742149 @default.
- W2016288300 cites W2007821628 @default.
- W2016288300 cites W2010070885 @default.
- W2016288300 cites W2013180460 @default.
- W2016288300 cites W2013801781 @default.
- W2016288300 cites W2016329603 @default.
- W2016288300 cites W2021481221 @default.
- W2016288300 cites W2024266901 @default.
- W2016288300 cites W2025146892 @default.
- W2016288300 cites W2027582069 @default.
- W2016288300 cites W2028512350 @default.
- W2016288300 cites W2028569029 @default.
- W2016288300 cites W2028968420 @default.
- W2016288300 cites W2030509093 @default.
- W2016288300 cites W2030789263 @default.
- W2016288300 cites W2035502791 @default.
- W2016288300 cites W2046045619 @default.
- W2016288300 cites W2046688088 @default.
- W2016288300 cites W2050132916 @default.
- W2016288300 cites W2052407549 @default.
- W2016288300 cites W2055573396 @default.
- W2016288300 cites W2056087001 @default.
- W2016288300 cites W2056752656 @default.
- W2016288300 cites W2059682917 @default.
- W2016288300 cites W2065422772 @default.
- W2016288300 cites W2071554281 @default.
- W2016288300 cites W2072811651 @default.
- W2016288300 cites W2076087769 @default.
- W2016288300 cites W2076747194 @default.
- W2016288300 cites W2077802746 @default.
- W2016288300 cites W2079279680 @default.
- W2016288300 cites W2080144750 @default.
- W2016288300 cites W2080152736 @default.
- W2016288300 cites W2082745248 @default.
- W2016288300 cites W2085221145 @default.
- W2016288300 cites W2087321947 @default.
- W2016288300 cites W2088366255 @default.
- W2016288300 cites W2106730339 @default.
- W2016288300 cites W2108569257 @default.
- W2016288300 cites W2110873651 @default.
- W2016288300 cites W2122702776 @default.
- W2016288300 cites W2126158230 @default.
- W2016288300 cites W2130483573 @default.
- W2016288300 cites W2135144225 @default.
- W2016288300 cites W2137494284 @default.
- W2016288300 cites W2141541691 @default.
- W2016288300 cites W2142570576 @default.
- W2016288300 cites W2148339830 @default.
- W2016288300 cites W2155107638 @default.
- W2016288300 cites W2155270270 @default.
- W2016288300 cites W2155615244 @default.
- W2016288300 cites W2156800133 @default.
- W2016288300 cites W2157983270 @default.