FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016290669> ?p ?o ?g. }

• W2016290669 endingPage "82" @default.
• W2016290669 startingPage "76" @default.
• W2016290669 abstract "Opioids have been increasingly used for pain control in the neonatal intensive care unit. Data from adult human studies have demonstrated suppressive effects of morphine sulfate on the immune system, owing in part to its inhibition of chemotaxis.To study the effect of morphine exposure on chemotaxis of newborn neutrophils compared with adult neutrophils.Blood samples were collected from adult controls and from the umbilical cord of healthy full-term newborns. Neutrophils were isolated and then exposed to morphine sulfate. Chemotaxis assays were performed using interleukin (IL)-8 as the chemoattractant. The migrated neutrophils were quantitated by flow cytometry. IL-8 receptor expression was evaluated by staining with an anti-IL-8 receptor-specific antibody. Chemotaxis and IL-8 receptor expression were compared between newborn and adult neutrophils.There was no difference in random migration between adult (n=10) and newborn neutrophils (n=14). IL-8 efficiently induced chemotaxis of both adult and newborn neutrophils, although newborn neutrophils exhibited significantly decreased chemotaxis compared with adult neutrophils: 389+/-197 newborn cells versus 731+/-190 adult cells (P=0.025). Exposure to morphine sulfate did not decrease chemotaxis of adult neutrophils but did modestly impair chemotaxis of newborn neutrophils. After exposure to morphine sulfate, adult neutrophils showed no difference in IL-8 receptor expression, whereas newborn neutrophils expressed fewer IL-8 receptors.Newborn neutrophils had reduced chemotaxis toward IL-8. Exposure to morphine sulfate further decreased their chemotactic function. The differential effect may be explained in part by the reduction of IL-8 receptors of newborn neutrophils after morphine exposure." @default.
• W2016290669 created "2016-06-24" @default.
• W2016290669 creator A5001663634 @default.
• W2016290669 creator A5014158638 @default.
• W2016290669 creator A5072463722 @default.
• W2016290669 creator A5089655253 @default.
• W2016290669 date "2008-01-01" @default.
• W2016290669 modified "2023-10-05" @default.
• W2016290669 title "Effect of Morphine Sulfate on Neonatal Neutrophil Chemotaxis" @default.
• W2016290669 cites W1486569222 @default.
• W2016290669 cites W1654077544 @default.
• W2016290669 cites W1975742983 @default.
• W2016290669 cites W1982563130 @default.
• W2016290669 cites W1984664129 @default.
• W2016290669 cites W2002942416 @default.
• W2016290669 cites W2010239869 @default.
• W2016290669 cites W2013055993 @default.
• W2016290669 cites W2014540856 @default.
• W2016290669 cites W2020069346 @default.
• W2016290669 cites W2020620814 @default.
• W2016290669 cites W2026283103 @default.
• W2016290669 cites W2026568037 @default.
• W2016290669 cites W2031997984 @default.
• W2016290669 cites W2033970784 @default.
• W2016290669 cites W2035646853 @default.
• W2016290669 cites W2039348809 @default.
• W2016290669 cites W2039470219 @default.
• W2016290669 cites W2052014337 @default.
• W2016290669 cites W2053760764 @default.
• W2016290669 cites W2053924743 @default.
• W2016290669 cites W2055683880 @default.
• W2016290669 cites W2056942256 @default.
• W2016290669 cites W2057481169 @default.
• W2016290669 cites W2068129049 @default.
• W2016290669 cites W2069783361 @default.
• W2016290669 cites W2070556051 @default.
• W2016290669 cites W2071543998 @default.
• W2016290669 cites W2074789446 @default.
• W2016290669 cites W2076360863 @default.
• W2016290669 cites W2078526529 @default.
• W2016290669 cites W2079645554 @default.
• W2016290669 cites W2085241965 @default.
• W2016290669 cites W2094068833 @default.
• W2016290669 cites W2101582799 @default.
• W2016290669 cites W2116118297 @default.
• W2016290669 cites W2119185052 @default.
• W2016290669 cites W2120188047 @default.
• W2016290669 cites W2133158084 @default.
• W2016290669 cites W2157863430 @default.
• W2016290669 cites W2158086238 @default.
• W2016290669 cites W2188705799 @default.
• W2016290669 cites W2467397297 @default.
• W2016290669 cites W4237461475 @default.
• W2016290669 doi "https://doi.org/10.1097/ajp.0b013e3181582c76" @default.
• W2016290669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18180640" @default.
• W2016290669 hasPublicationYear "2008" @default.
• W2016290669 type Work @default.
• W2016290669 sameAs 2016290669 @default.
• W2016290669 citedByCount "24" @default.
• W2016290669 countsByYear W20162906692012 @default.
• W2016290669 countsByYear W20162906692014 @default.
• W2016290669 countsByYear W20162906692015 @default.
• W2016290669 countsByYear W20162906692016 @default.
• W2016290669 countsByYear W20162906692018 @default.
• W2016290669 countsByYear W20162906692019 @default.
• W2016290669 countsByYear W20162906692020 @default.
• W2016290669 countsByYear W20162906692022 @default.
• W2016290669 crossrefType "journal-article" @default.
• W2016290669 hasAuthorship W2016290669A5001663634 @default.
• W2016290669 hasAuthorship W2016290669A5014158638 @default.
• W2016290669 hasAuthorship W2016290669A5072463722 @default.
• W2016290669 hasAuthorship W2016290669A5089655253 @default.
• W2016290669 hasConcept C126322002 @default.
• W2016290669 hasConcept C134018914 @default.
• W2016290669 hasConcept C170493617 @default.
• W2016290669 hasConcept C203014093 @default.
• W2016290669 hasConcept C2777389121 @default.
• W2016290669 hasConcept C2779866169 @default.
• W2016290669 hasConcept C54166955 @default.
• W2016290669 hasConcept C71924100 @default.
• W2016290669 hasConceptScore W2016290669C126322002 @default.
• W2016290669 hasConceptScore W2016290669C134018914 @default.
• W2016290669 hasConceptScore W2016290669C170493617 @default.
• W2016290669 hasConceptScore W2016290669C203014093 @default.
• W2016290669 hasConceptScore W2016290669C2777389121 @default.
• W2016290669 hasConceptScore W2016290669C2779866169 @default.
• W2016290669 hasConceptScore W2016290669C54166955 @default.
• W2016290669 hasConceptScore W2016290669C71924100 @default.
• W2016290669 hasIssue "1" @default.
• W2016290669 hasLocation W20162906691 @default.
• W2016290669 hasLocation W20162906692 @default.
• W2016290669 hasOpenAccess W2016290669 @default.
• W2016290669 hasPrimaryLocation W20162906691 @default.
• W2016290669 hasRelatedWork W1510733163 @default.
• W2016290669 hasRelatedWork W1996846474 @default.
• W2016290669 hasRelatedWork W2018368842 @default.
• W2016290669 hasRelatedWork W2033472167 @default.
• W2016290669 hasRelatedWork W2034583712 @default.

• next