Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016291340> ?p ?o ?g. }
- W2016291340 endingPage "7932" @default.
- W2016291340 startingPage "7919" @default.
- W2016291340 abstract "Muscle-specific tyrosine kinase receptor (MuSK) has been believed to be mainly expressed and functional in muscle, in which it mediates the formation of neuromuscular junctions. Here we show that MuSK is expressed in the brain, particularly in neurons, as well as in non-neuronal tissues. We also provide evidence that MuSK expression in the hippocampus is required for memory consolidation, because temporally restricted knockdown after training impairs memory retention. Hippocampal disruption of MuSK also prevents the learning-dependent induction of both cAMP response element binding protein (CREB) phosphorylation and CCAAT enhancer binding protein β (C/EBPβ) expression, suggesting that the role of MuSK during memory consolidation critically involves the CREB–C/EBP pathway. Furthermore, we found that MuSK also plays an important role in mediating hippocampal oscillatory activity in the theta frequency as well as in the induction and maintenance of long-term potentiation, two synaptic responses that correlate with memory formation. We conclude that MuSK plays an important role in brain functions, including memory formation. Therefore, its expression and role are broader than what was believed previously." @default.
- W2016291340 created "2016-06-24" @default.
- W2016291340 creator A5004762623 @default.
- W2016291340 creator A5008025407 @default.
- W2016291340 creator A5009106795 @default.
- W2016291340 creator A5062234402 @default.
- W2016291340 creator A5062694940 @default.
- W2016291340 creator A5082605513 @default.
- W2016291340 date "2006-07-26" @default.
- W2016291340 modified "2023-10-18" @default.
- W2016291340 title "MuSK Expressed in the Brain Mediates Cholinergic Responses, Synaptic Plasticity, and Memory Formation" @default.
- W2016291340 cites W1485187747 @default.
- W2016291340 cites W1487695731 @default.
- W2016291340 cites W1493574533 @default.
- W2016291340 cites W1542081124 @default.
- W2016291340 cites W1568142966 @default.
- W2016291340 cites W1658884838 @default.
- W2016291340 cites W1770029100 @default.
- W2016291340 cites W1877348036 @default.
- W2016291340 cites W1912613254 @default.
- W2016291340 cites W1920124704 @default.
- W2016291340 cites W1946757792 @default.
- W2016291340 cites W1967865726 @default.
- W2016291340 cites W1967946964 @default.
- W2016291340 cites W1970393142 @default.
- W2016291340 cites W1970681929 @default.
- W2016291340 cites W1978726685 @default.
- W2016291340 cites W1980120506 @default.
- W2016291340 cites W1982578824 @default.
- W2016291340 cites W1982970002 @default.
- W2016291340 cites W1989114376 @default.
- W2016291340 cites W1990410457 @default.
- W2016291340 cites W1991108340 @default.
- W2016291340 cites W1991758498 @default.
- W2016291340 cites W1993249954 @default.
- W2016291340 cites W1995759274 @default.
- W2016291340 cites W1996196390 @default.
- W2016291340 cites W1997679949 @default.
- W2016291340 cites W2007430976 @default.
- W2016291340 cites W2008256279 @default.
- W2016291340 cites W2010643920 @default.
- W2016291340 cites W2013331112 @default.
- W2016291340 cites W2018379578 @default.
- W2016291340 cites W2018662966 @default.
- W2016291340 cites W2020836040 @default.
- W2016291340 cites W2023382980 @default.
- W2016291340 cites W2034787916 @default.
- W2016291340 cites W2036309197 @default.
- W2016291340 cites W2036453589 @default.
- W2016291340 cites W2036714661 @default.
- W2016291340 cites W2044199827 @default.
- W2016291340 cites W2045732157 @default.
- W2016291340 cites W2049948139 @default.
- W2016291340 cites W2055019130 @default.
- W2016291340 cites W2056336718 @default.
- W2016291340 cites W2057313033 @default.
- W2016291340 cites W2057983666 @default.
- W2016291340 cites W2059089847 @default.
- W2016291340 cites W2062815625 @default.
- W2016291340 cites W2069863147 @default.
- W2016291340 cites W2074620251 @default.
- W2016291340 cites W2079403009 @default.
- W2016291340 cites W2079507958 @default.
- W2016291340 cites W2083405476 @default.
- W2016291340 cites W2086874557 @default.
- W2016291340 cites W2115736826 @default.
- W2016291340 cites W2119302018 @default.
- W2016291340 cites W2121662086 @default.
- W2016291340 cites W2133083344 @default.
- W2016291340 cites W2133850147 @default.
- W2016291340 cites W2134505400 @default.
- W2016291340 cites W2148646540 @default.
- W2016291340 cites W2149567843 @default.
- W2016291340 cites W2152284832 @default.
- W2016291340 cites W2152372327 @default.
- W2016291340 cites W2160180740 @default.
- W2016291340 cites W2160205278 @default.
- W2016291340 cites W2161251796 @default.
- W2016291340 cites W2313176671 @default.
- W2016291340 cites W2401273009 @default.
- W2016291340 cites W2415630344 @default.
- W2016291340 cites W2472727240 @default.
- W2016291340 cites W4235090236 @default.
- W2016291340 doi "https://doi.org/10.1523/jneurosci.1674-06.2006" @default.
- W2016291340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674217" @default.
- W2016291340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16870737" @default.
- W2016291340 hasPublicationYear "2006" @default.
- W2016291340 type Work @default.
- W2016291340 sameAs 2016291340 @default.
- W2016291340 citedByCount "84" @default.
- W2016291340 countsByYear W20162913402012 @default.
- W2016291340 countsByYear W20162913402013 @default.
- W2016291340 countsByYear W20162913402014 @default.
- W2016291340 countsByYear W20162913402015 @default.
- W2016291340 countsByYear W20162913402016 @default.
- W2016291340 countsByYear W20162913402017 @default.
- W2016291340 countsByYear W20162913402018 @default.
- W2016291340 countsByYear W20162913402019 @default.