FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016292471> ?p ?o ?g. }

• W2016292471 endingPage "8164" @default.
• W2016292471 startingPage "8160" @default.
• W2016292471 abstract "The amyloid beta (A beta) peptide of Alzheimer's disease binds copper(II), and the peptide-bound metal may be a source of reactive oxygen species and neurotoxicity. To circumvent peptide aggregation and reduce redox activity, there is growing interest in using metal chelates as drug therapeutics for AD, whose design requires accurate data on the affinity of A beta peptides for copper(II). Reports on Cu2+ binding to A beta range from approximately 10(5) to approximately 10(9); these values' being obtained for different peptide lengths (1-16, 1-28, 1-40, 1-42) at varying pH. Herein, we report that Cu2+'s binding to A beta(1-40) at 37 degrees C occurs in a 1:1 stoichiometry with a pH-dependent binding constant: 1.1 (+/-0.2) x 10 (9) M (-1) and 2.4 (+/-0.2) x 10 (9) M(-1) at pH 7.2 and 7.4, respectively. Under identical conditions, A beta(1-16) reveals a comparable binding constant, confirming that this portion of the peptide is the binding region. Several previously reported values can be reconciled with the current measurement by careful consideration of thermodynamics associated with the presence of competing ligands used to solubilize copper." @default.
• W2016292471 created "2016-06-24" @default.
• W2016292471 creator A5044120373 @default.
• W2016292471 creator A5053835038 @default.
• W2016292471 creator A5065431928 @default.
• W2016292471 creator A5067633080 @default.
• W2016292471 creator A5090130779 @default.
• W2016292471 date "2008-06-18" @default.
• W2016292471 modified "2023-10-14" @default.
• W2016292471 title "Quantification of the Binding Constant of Copper(II) to the Amyloid-Beta Peptide" @default.
• W2016292471 cites W1526023859 @default.
• W2016292471 cites W1731253253 @default.
• W2016292471 cites W1966618264 @default.
• W2016292471 cites W1975829681 @default.
• W2016292471 cites W1983735656 @default.
• W2016292471 cites W1989403800 @default.
• W2016292471 cites W1996579240 @default.
• W2016292471 cites W2002330213 @default.
• W2016292471 cites W2003470534 @default.
• W2016292471 cites W2005459756 @default.
• W2016292471 cites W2009833553 @default.
• W2016292471 cites W2018333394 @default.
• W2016292471 cites W2019511555 @default.
• W2016292471 cites W2022830173 @default.
• W2016292471 cites W2027123848 @default.
• W2016292471 cites W2039161703 @default.
• W2016292471 cites W2041230020 @default.
• W2016292471 cites W2051516838 @default.
• W2016292471 cites W2064962462 @default.
• W2016292471 cites W2068609215 @default.
• W2016292471 cites W2070090190 @default.
• W2016292471 cites W2079323065 @default.
• W2016292471 cites W2081099437 @default.
• W2016292471 cites W2083500052 @default.
• W2016292471 cites W2084174305 @default.
• W2016292471 cites W2096410114 @default.
• W2016292471 cites W2106756683 @default.
• W2016292471 cites W2113472155 @default.
• W2016292471 cites W2113950441 @default.
• W2016292471 cites W2125179812 @default.
• W2016292471 cites W2133324295 @default.
• W2016292471 doi "https://doi.org/10.1021/jp710806s" @default.
• W2016292471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18558757" @default.
• W2016292471 hasPublicationYear "2008" @default.
• W2016292471 type Work @default.
• W2016292471 sameAs 2016292471 @default.
• W2016292471 citedByCount "107" @default.
• W2016292471 countsByYear W20162924712012 @default.
• W2016292471 countsByYear W20162924712013 @default.
• W2016292471 countsByYear W20162924712014 @default.
• W2016292471 countsByYear W20162924712015 @default.
• W2016292471 countsByYear W20162924712016 @default.
• W2016292471 countsByYear W20162924712017 @default.
• W2016292471 countsByYear W20162924712018 @default.
• W2016292471 countsByYear W20162924712019 @default.
• W2016292471 countsByYear W20162924712020 @default.
• W2016292471 countsByYear W20162924712021 @default.
• W2016292471 countsByYear W20162924712022 @default.
• W2016292471 countsByYear W20162924712023 @default.
• W2016292471 crossrefType "journal-article" @default.
• W2016292471 hasAuthorship W2016292471A5044120373 @default.
• W2016292471 hasAuthorship W2016292471A5053835038 @default.
• W2016292471 hasAuthorship W2016292471A5065431928 @default.
• W2016292471 hasAuthorship W2016292471A5067633080 @default.
• W2016292471 hasAuthorship W2016292471A5090130779 @default.
• W2016292471 hasConcept C107824862 @default.
• W2016292471 hasConcept C144082473 @default.
• W2016292471 hasConcept C147789679 @default.
• W2016292471 hasConcept C178790620 @default.
• W2016292471 hasConcept C179104552 @default.
• W2016292471 hasConcept C185592680 @default.
• W2016292471 hasConcept C197404232 @default.
• W2016292471 hasConcept C199360897 @default.
• W2016292471 hasConcept C2776156579 @default.
• W2016292471 hasConcept C2776174256 @default.
• W2016292471 hasConcept C2779281246 @default.
• W2016292471 hasConcept C2779491297 @default.
• W2016292471 hasConcept C29730261 @default.
• W2016292471 hasConcept C32786932 @default.
• W2016292471 hasConcept C41008148 @default.
• W2016292471 hasConcept C544153396 @default.
• W2016292471 hasConcept C544778455 @default.
• W2016292471 hasConcept C55493867 @default.
• W2016292471 hasConcept C71240020 @default.
• W2016292471 hasConcept C8010536 @default.
• W2016292471 hasConceptScore W2016292471C107824862 @default.
• W2016292471 hasConceptScore W2016292471C144082473 @default.
• W2016292471 hasConceptScore W2016292471C147789679 @default.
• W2016292471 hasConceptScore W2016292471C178790620 @default.
• W2016292471 hasConceptScore W2016292471C179104552 @default.
• W2016292471 hasConceptScore W2016292471C185592680 @default.
• W2016292471 hasConceptScore W2016292471C197404232 @default.
• W2016292471 hasConceptScore W2016292471C199360897 @default.
• W2016292471 hasConceptScore W2016292471C2776156579 @default.
• W2016292471 hasConceptScore W2016292471C2776174256 @default.
• W2016292471 hasConceptScore W2016292471C2779281246 @default.
• W2016292471 hasConceptScore W2016292471C2779491297 @default.
• W2016292471 hasConceptScore W2016292471C29730261 @default.

• next