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• W2016292914 abstract "ABSTRACT MK-3118 is as an orally active new antifungal in the early stage of clinical development that inhibits the biosynthesis of β-(1,3)-glucan. We evaluated the in vitro activity of this compound against wild-type and echinocandin-resistant (ER) isolates containing mutations in the FKS gene(s) of Candida spp. and Aspergillus spp. MK-3118 demonstrated enhanced efficacy for most C. albicans and C. glabrata ER isolates relative to caspofungin, with decreased MICs and half-maximal inhibitory concentrations (IC 50 s)." @default.
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• W2016292914 date "2014-02-01" @default.
• W2016292914 modified "2023-10-12" @default.
• W2016292914 title "Enfumafungin Derivative MK-3118 Shows Increased <i>In Vitro</i> Potency against Clinical Echinocandin-Resistant Candida Species and Aspergillus Species Isolates" @default.
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• W2016292914 doi "https://doi.org/10.1128/aac.02145-13" @default.
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