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• W2016293879 abstract "Chromosome aberrations are detected in only 50% of patients with chronic lymphocytic leukemia (CLL), owing usually to the low mitotic rate exhibited by the neoplastic lymphocytes. Fluorescence in situ hybridization (FISH) is a simple method for identifying numerical abnormalities of the target chromosome in interphase nuclei. Therefore, we used the FISH procedure with chromosome 12-specific a-satellite probe to evaluate 19 patients with CLL. Trisomy 12 was detected in interphase cells of 12 patients (63%). Cytogenetic analysis, performed in nine patients, yielded trisomy 12 in four (44%). FISH detected three patients with trisomy 12 in whom conventional cytogenetic method yielded a normal karyotype. FISH is a simple, reliable, and sensitive method for detection of trisomy 12 in patients with CLL." @default.
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• W2016293879 date "1993-10-01" @default.
• W2016293879 modified "2023-09-25" @default.
• W2016293879 title "In situ hybridization: A simple and sensitive method for detection of trisomy 12 in chronic lymphocytic leukemia" @default.
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• W2016293879 doi "https://doi.org/10.1016/0165-4608(93)90126-7" @default.
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