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- W2016294202 abstract "In mice, epicutaneous immunotherapy (EPIT) increases Foxp3+ regulatory T cells (Tregs) (Dioszeghy, J Immunol 2011). Tregs could display distinct efficacy based on their expression of homing molecules. The aim of this study was to evaluate homing receptors expression by Tregs induced during EPIT compared to sublingual (SLIT) or subcutaneous (SCIT) immunotherapy. Mice were sensitized to peanuts and divided into 4 groups: EPIT, SLIT, SCIT and not treated (Sham). After 8 weeks of treatment with 100μg of peanut protein extract, the proportion of Tregs in spleen, inguinal and mesenteric lymph node (iLN or mLN) were evaluated and the expression of homing receptors by spleen Tregs was analyzed by flow cytometry. EPIT, SLIT and SCIT increased Foxp3+ Tregs in spleen compared to Sham (p<0.001), EPIT more than SLIT (p<0.001) and SCIT (p<0.05). Concerning migration to the lung, expression of CCR4 was increased on Tregs induced by the three therapies whereas migration to the skin measured by CLA expression was increased only in EPIT and SCIT treated mice. Consistently only EPIT and SCIT increased Tregs level in iLN (p<0.01). For gut homing, EPIT, SLIT and SCIT significantly increased Tregs in mLN compared to Sham (p<0.01) but only EPIT induced higher expression of CCR9 on spleen Tregs. Moreover, the expression of CXCR3, CCR6 and CCR8 was increased on EPIT-induced Tregs but not in SLIT or SCIT. Larger and stronger expression of homing receptors on Tregs was achieved with EPIT compared to SLIT supporting the clinical applications of EPIT in various allergies." @default.
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- W2016294202 date "2014-02-01" @default.
- W2016294202 modified "2023-10-16" @default.
- W2016294202 title "Epicutaneous Immunotherapy-Induced Regulatory T Cells Could Migrate To More Various Sites Of Allergen Exposure Compared To Sublingual Or Subcutaneous Immunotherapy In Mice Sensitized To Peanut" @default.
- W2016294202 doi "https://doi.org/10.1016/j.jaci.2013.12.196" @default.
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