FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016297875> ?p ?o ?g. }

• W2016297875 endingPage "1058" @default.
• W2016297875 startingPage "1050" @default.
• W2016297875 abstract "Hematopoietic stem cell transplant patients are susceptible to infection despite cellular reconstitution. In a murine model of syngeneic bone marrow transplantation (BMT), we previously reported that BMT mice have impaired host defense against Pseudomonas aeruginosa pneumonia due to overproduction of (PG)E(2) in lung. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is an effector in the PGE(2) signaling pathway that negatively regulates alveolar macrophage (AM) phagocytosis and bacterial killing. Therefore, examined whether overproduction of PGE(2) after BMT inhibits AM host defense by up-regulating PTEN phosphatase activity. We found that PTEN activity is elevated in BMT AMs in response to increased PGE(2) signaling and that pharmacological inhibition of PTEN activity in BMT AMs fully restores phagocytosis of serum-opsonized P. aeruginosa but only partially restores phagocytosis of nonopsonized P. aeruginosa. In wild-type mice transplanted with myeloid-specific conditional PTEN knockout (PTEN CKO) bone marrow, bacterial clearance is improved after challenge with P. aeruginosa pneumonia. Furthermore, PTEN CKO BMT AMs display improved TNF-α production and enhanced phagocytosis and killing of serum-opsonized P. aeruginosa despite overproduction of PGE(2). However, AM phagocytosis of nonopsonized P. aeruginosa is only partially restored in the absence of PTEN after BMT. This may be related to elevated AM expression of IL-1 receptor-associated kinase (IRAK)-M, a molecule previously identified in the PGE(2) signaling pathway to inhibit AM phagocytosis of nonopsonized bacteria. These data suggest that PGE(2) signaling up-regulates IRAK-M independently of PTEN and that these molecules differentially inhibit opsonized and nonopsonized phagocytosis of P. aeruginosa." @default.
• W2016297875 created "2016-06-24" @default.
• W2016297875 creator A5023482526 @default.
• W2016297875 creator A5026923300 @default.
• W2016297875 creator A5044744603 @default.
• W2016297875 creator A5055183282 @default.
• W2016297875 date "2011-11-01" @default.
• W2016297875 modified "2023-09-27" @default.
• W2016297875 title "PTEN Limits Alveolar Macrophage Function against<i>Pseudomonas aeruginosa</i>after Bone Marrow Transplantation" @default.
• W2016297875 cites W1480620997 @default.
• W2016297875 cites W1524123582 @default.
• W2016297875 cites W1525044292 @default.
• W2016297875 cites W1595072120 @default.
• W2016297875 cites W1659193542 @default.
• W2016297875 cites W1669895089 @default.
• W2016297875 cites W1919688027 @default.
• W2016297875 cites W2009662910 @default.
• W2016297875 cites W2010176851 @default.
• W2016297875 cites W2022000203 @default.
• W2016297875 cites W2023353555 @default.
• W2016297875 cites W2023661694 @default.
• W2016297875 cites W2037054057 @default.
• W2016297875 cites W2043508302 @default.
• W2016297875 cites W2047385780 @default.
• W2016297875 cites W2048648009 @default.
• W2016297875 cites W2051170249 @default.
• W2016297875 cites W2056525578 @default.
• W2016297875 cites W2059281747 @default.
• W2016297875 cites W2062472841 @default.
• W2016297875 cites W2067548550 @default.
• W2016297875 cites W2069440395 @default.
• W2016297875 cites W2100293996 @default.
• W2016297875 cites W2100983995 @default.
• W2016297875 cites W2104603012 @default.
• W2016297875 cites W2104728637 @default.
• W2016297875 cites W2106994186 @default.
• W2016297875 cites W2107365801 @default.
• W2016297875 cites W2115287428 @default.
• W2016297875 cites W2120549809 @default.
• W2016297875 cites W2120688765 @default.
• W2016297875 cites W2136861576 @default.
• W2016297875 cites W2140425615 @default.
• W2016297875 cites W2144689930 @default.
• W2016297875 cites W2145307509 @default.
• W2016297875 cites W2148360609 @default.
• W2016297875 cites W2151453138 @default.
• W2016297875 cites W2151702529 @default.
• W2016297875 cites W2153048580 @default.
• W2016297875 cites W2159456144 @default.
• W2016297875 cites W2160666689 @default.
• W2016297875 cites W2162516601 @default.
• W2016297875 cites W2170992468 @default.
• W2016297875 cites W2399493597 @default.
• W2016297875 doi "https://doi.org/10.1165/rcmb.2011-0079oc" @default.
• W2016297875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3361361" @default.
• W2016297875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21527775" @default.
• W2016297875 hasPublicationYear "2011" @default.
• W2016297875 type Work @default.
• W2016297875 sameAs 2016297875 @default.
• W2016297875 citedByCount "24" @default.
• W2016297875 countsByYear W20162978752012 @default.
• W2016297875 countsByYear W20162978752013 @default.
• W2016297875 countsByYear W20162978752014 @default.
• W2016297875 countsByYear W20162978752015 @default.
• W2016297875 countsByYear W20162978752017 @default.
• W2016297875 countsByYear W20162978752018 @default.
• W2016297875 countsByYear W20162978752019 @default.
• W2016297875 countsByYear W20162978752021 @default.
• W2016297875 countsByYear W20162978752022 @default.
• W2016297875 countsByYear W20162978752023 @default.
• W2016297875 crossrefType "journal-article" @default.
• W2016297875 hasAuthorship W2016297875A5023482526 @default.
• W2016297875 hasAuthorship W2016297875A5026923300 @default.
• W2016297875 hasAuthorship W2016297875A5044744603 @default.
• W2016297875 hasAuthorship W2016297875A5055183282 @default.
• W2016297875 hasBestOaLocation W20162978752 @default.
• W2016297875 hasConcept C160448771 @default.
• W2016297875 hasConcept C203014093 @default.
• W2016297875 hasConcept C2777609662 @default.
• W2016297875 hasConcept C2777637488 @default.
• W2016297875 hasConcept C2779549131 @default.
• W2016297875 hasConcept C2780007613 @default.
• W2016297875 hasConcept C502942594 @default.
• W2016297875 hasConcept C523546767 @default.
• W2016297875 hasConcept C54355233 @default.
• W2016297875 hasConcept C62478195 @default.
• W2016297875 hasConcept C86554907 @default.
• W2016297875 hasConcept C86803240 @default.
• W2016297875 hasConcept C89423630 @default.
• W2016297875 hasConcept C95444343 @default.
• W2016297875 hasConceptScore W2016297875C160448771 @default.
• W2016297875 hasConceptScore W2016297875C203014093 @default.
• W2016297875 hasConceptScore W2016297875C2777609662 @default.
• W2016297875 hasConceptScore W2016297875C2777637488 @default.
• W2016297875 hasConceptScore W2016297875C2779549131 @default.
• W2016297875 hasConceptScore W2016297875C2780007613 @default.
• W2016297875 hasConceptScore W2016297875C502942594 @default.
• W2016297875 hasConceptScore W2016297875C523546767 @default.

• next