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• W2016300254 abstract "Abstract: Immunocytochemical and immunoblotting techniques were used to investigate calpain I activation and the stability of the calpain‐sensitive cytoskeletal proteins microtubule‐associated protein 2 (MAP2) and spectrin at 1, 4, and 24 h after contusion injury to the spinal cord. Spinal cord injury resulted in the activation of calpain I at all time points examined, with the highest level of activation occurring at 1 h. At the same early time point, there was a loss of dendritic MAP2 staining in spinal cord sections, accompanied by pronounced perikaryal accumulation. The loss in MAP2 staining in the injured spinal cord progressed over the 24‐h survival period to affect regions 3 mm distant to the site of injury. The presence of calpain I‐specific spectrin degradation was apparent in neuronal cell bodies and fibers as early as 1 h after injury, with the most intense staining occurring within and juxtaposed to the injury site. Spectrin breakdown products in neuronal cell bodies declined rapidly at 4 h and were nearly undetectable at 24 h after injury. Immunoblot studies confirmed the immunocytochemical results by demonstrating a significant increase in calpain I activation, a significant decrease in MAP2 levels, and a significant increase in spectrin breakdown. Finally, treatment of animals with riluzole, an inhibitor of glutamate release, before surgery reduced significantly the loss of MAP2 levels observed at 24 h after injury. These results demonstrate that Ca 2+ ‐dependent protease activation and degradation of critical cytoskeletal proteins are early events after spinal cord injury and that treatments that minimize the actions of glutamate may limit their breakdown." @default.
• W2016300254 created "2016-06-24" @default.
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• W2016300254 date "1997-10-01" @default.
• W2016300254 modified "2023-10-13" @default.
• W2016300254 title "Rapid Calpain I Activation and Cytoskeletal Protein Degradation Following Traumatic Spinal Cord Injury: Attenuation with Riluzole Pretreatment" @default.
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• W2016300254 doi "https://doi.org/10.1046/j.1471-4159.1997.69041592.x" @default.
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