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- W2016301178 abstract "Abstract We previously identified JAZ as a novel zinc finger (ZF) protein by screening a murine interleukin-3 (IL-3)–dependent NFS/N1.H7 myeloid cell cDNA library. JAZ is a member of a new class of ZFPs that is evolutionarily conserved and preferentially binds to dsRNA, but its function was unknown. Now, we report that the stress of IL-3 growth factor withdrawal up-regulates JAZ expression in hematopoietic cells in association with p53 activation and induction of cell death. Biochemical analysis reveals that JAZ associates with p53 to stimulate its transcriptional activity in p53-expressing cells, but not in p53-null cells unless complemented with p53. JAZ functions to mediate G1 cell-cycle arrest followed by apoptosis in a p53-dependent mechanism that is associated with up-regulation of p21 and BAX, dephosphorylation of Rb, and repression of cyclin A. Of importance, siRNA “knockdown” of endogenous JAZ inhibits p53 transcriptional activity, decreases the G1/G0 population, and attenuates stress-induced cell death. While JAZ directly binds p53 in vitro in a mechanism requiring p53's C-terminal regulatory domain but independent of dsRNA, the dsRNA-binding ZF domains are required for JAZ's stimulatory role of p53 in vivo by dictating its nuclear localization. Thus, JAZ is a novel negative regulator of cell growth by positively regulating p53." @default.
- W2016301178 created "2016-06-24" @default.
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- W2016301178 date "2006-12-15" @default.
- W2016301178 modified "2023-10-09" @default.
- W2016301178 title "JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity" @default.
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- W2016301178 cites W1608920950 @default.
- W2016301178 cites W1616121322 @default.
- W2016301178 cites W1650797637 @default.
- W2016301178 cites W1781373502 @default.
- W2016301178 cites W1963795701 @default.
- W2016301178 cites W1964173713 @default.
- W2016301178 cites W1965581435 @default.
- W2016301178 cites W1966081420 @default.
- W2016301178 cites W1966895878 @default.
- W2016301178 cites W1978340521 @default.
- W2016301178 cites W1978775178 @default.
- W2016301178 cites W1980645183 @default.
- W2016301178 cites W1981967708 @default.
- W2016301178 cites W1982305402 @default.
- W2016301178 cites W1983751803 @default.
- W2016301178 cites W1984547206 @default.
- W2016301178 cites W1992667313 @default.
- W2016301178 cites W1995270127 @default.
- W2016301178 cites W1998287298 @default.
- W2016301178 cites W2002292653 @default.
- W2016301178 cites W2003236156 @default.
- W2016301178 cites W2008797552 @default.
- W2016301178 cites W2008887283 @default.
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- W2016301178 cites W2026072962 @default.
- W2016301178 cites W2039463309 @default.
- W2016301178 cites W2044884879 @default.
- W2016301178 cites W2051293500 @default.
- W2016301178 cites W2053305234 @default.
- W2016301178 cites W2063669247 @default.
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- W2016301178 cites W2094773427 @default.
- W2016301178 cites W2103340147 @default.
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- W2016301178 cites W2315441528 @default.
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- W2016301178 doi "https://doi.org/10.1182/blood-2006-06-029645" @default.
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