FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016306602> ?p ?o ?g. }

• W2016306602 endingPage "305" @default.
• W2016306602 startingPage "299" @default.
• W2016306602 abstract "FCE 28260 is a novel inhibitor of 5α-reductase (5αR), the enzyme responsible for the conversion of testosterone (T) to 5α-dihydrotestosterone (DHT). The compound caused inhibition of rat and human prostatic enzymes, with IC50 values of 15 and 16 nM, respectively, compared to the values of 30 and 52 nM shown by finasteride. Furthermore, FCE 28260 was highly potent in inhibiting human recombinant 5αR type 2 and 1 isozymes, showing IC50 values of 3.3 and 36 nM, and therefore it was more potent than finasteride (IC50 values of 8.5 and 470 nM) on both isozymes. In prepubertal, T-implanted castrated rats, FCE 28260, given orally for 7 days, reduced ventral prostate growth with an ED50 of 0.8 mg/kg, i.e. five times lower than that shown by finasteride. No anti-androgenic activity in DHT-implanted castrated rats was found up to 10 mg/kg/day. In adult male rats, FCE 28260 reduced prostatic DHT concentrations 6 h after oral dosing with a potency similar to that of finasteride (65% reduction at 1 mg/kg) but was found to be markedly more potent than the reference compound at 24 h (74% reduction in prostate DHT at 10 mg/kg, compared to 26% reduction induced by finasteride). These results indicate that FCE 28260 represents a marked improvement over finasteride." @default.
• W2016306602 created "2016-06-24" @default.
• W2016306602 creator A5016710148 @default.
• W2016306602 creator A5031069328 @default.
• W2016306602 creator A5032213495 @default.
• W2016306602 creator A5042524180 @default.
• W2016306602 creator A5045194470 @default.
• W2016306602 creator A5050537557 @default.
• W2016306602 creator A5056344051 @default.
• W2016306602 creator A5059642235 @default.
• W2016306602 date "1996-06-01" @default.
• W2016306602 modified "2023-10-18" @default.
• W2016306602 title "FCE 28260, a new 5α-reductase inhibitor: In vitro and in vivo effects" @default.
• W2016306602 cites W107210901 @default.
• W2016306602 cites W1482831570 @default.
• W2016306602 cites W1974392957 @default.
• W2016306602 cites W1984610064 @default.
• W2016306602 cites W1996738221 @default.
• W2016306602 cites W2000173210 @default.
• W2016306602 cites W2015746645 @default.
• W2016306602 cites W2027175495 @default.
• W2016306602 cites W2029706340 @default.
• W2016306602 cites W2031413293 @default.
• W2016306602 cites W2033040464 @default.
• W2016306602 cites W2047589511 @default.
• W2016306602 cites W2050842469 @default.
• W2016306602 cites W2057761968 @default.
• W2016306602 cites W2058387263 @default.
• W2016306602 cites W2081251422 @default.
• W2016306602 cites W2091055148 @default.
• W2016306602 cites W2093140451 @default.
• W2016306602 cites W2413346246 @default.
• W2016306602 doi "https://doi.org/10.1016/0960-0760(96)00040-4" @default.
• W2016306602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8836165" @default.
• W2016306602 hasPublicationYear "1996" @default.
• W2016306602 type Work @default.
• W2016306602 sameAs 2016306602 @default.
• W2016306602 citedByCount "18" @default.
• W2016306602 countsByYear W20163066022013 @default.
• W2016306602 countsByYear W20163066022016 @default.
• W2016306602 countsByYear W20163066022018 @default.
• W2016306602 crossrefType "journal-article" @default.
• W2016306602 hasAuthorship W2016306602A5016710148 @default.
• W2016306602 hasAuthorship W2016306602A5031069328 @default.
• W2016306602 hasAuthorship W2016306602A5032213495 @default.
• W2016306602 hasAuthorship W2016306602A5042524180 @default.
• W2016306602 hasAuthorship W2016306602A5045194470 @default.
• W2016306602 hasAuthorship W2016306602A5050537557 @default.
• W2016306602 hasAuthorship W2016306602A5056344051 @default.
• W2016306602 hasAuthorship W2016306602A5059642235 @default.
• W2016306602 hasConcept C119795356 @default.
• W2016306602 hasConcept C121608353 @default.
• W2016306602 hasConcept C126322002 @default.
• W2016306602 hasConcept C134018914 @default.
• W2016306602 hasConcept C150903083 @default.
• W2016306602 hasConcept C181199279 @default.
• W2016306602 hasConcept C185592680 @default.
• W2016306602 hasConcept C202751555 @default.
• W2016306602 hasConcept C207001950 @default.
• W2016306602 hasConcept C2775874879 @default.
• W2016306602 hasConcept C2776235491 @default.
• W2016306602 hasConcept C2776980637 @default.
• W2016306602 hasConcept C2777752497 @default.
• W2016306602 hasConcept C2777911890 @default.
• W2016306602 hasConcept C2779279991 @default.
• W2016306602 hasConcept C2779881493 @default.
• W2016306602 hasConcept C42533223 @default.
• W2016306602 hasConcept C55493867 @default.
• W2016306602 hasConcept C57992300 @default.
• W2016306602 hasConcept C71315377 @default.
• W2016306602 hasConcept C71924100 @default.
• W2016306602 hasConcept C86803240 @default.
• W2016306602 hasConcept C98274493 @default.
• W2016306602 hasConceptScore W2016306602C119795356 @default.
• W2016306602 hasConceptScore W2016306602C121608353 @default.
• W2016306602 hasConceptScore W2016306602C126322002 @default.
• W2016306602 hasConceptScore W2016306602C134018914 @default.
• W2016306602 hasConceptScore W2016306602C150903083 @default.
• W2016306602 hasConceptScore W2016306602C181199279 @default.
• W2016306602 hasConceptScore W2016306602C185592680 @default.
• W2016306602 hasConceptScore W2016306602C202751555 @default.
• W2016306602 hasConceptScore W2016306602C207001950 @default.
• W2016306602 hasConceptScore W2016306602C2775874879 @default.
• W2016306602 hasConceptScore W2016306602C2776235491 @default.
• W2016306602 hasConceptScore W2016306602C2776980637 @default.
• W2016306602 hasConceptScore W2016306602C2777752497 @default.
• W2016306602 hasConceptScore W2016306602C2777911890 @default.
• W2016306602 hasConceptScore W2016306602C2779279991 @default.
• W2016306602 hasConceptScore W2016306602C2779881493 @default.
• W2016306602 hasConceptScore W2016306602C42533223 @default.
• W2016306602 hasConceptScore W2016306602C55493867 @default.
• W2016306602 hasConceptScore W2016306602C57992300 @default.
• W2016306602 hasConceptScore W2016306602C71315377 @default.
• W2016306602 hasConceptScore W2016306602C71924100 @default.
• W2016306602 hasConceptScore W2016306602C86803240 @default.
• W2016306602 hasConceptScore W2016306602C98274493 @default.
• W2016306602 hasIssue "3" @default.
• W2016306602 hasLocation W20163066021 @default.

• next