Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016308603> ?p ?o ?g. }
- W2016308603 endingPage "48" @default.
- W2016308603 startingPage "37" @default.
- W2016308603 abstract "In this review, we sum up the research carried out over two decades on mitochondrial DNA (mtDNA) replication, primarily by comparing this system in Saccharomyces cerevisiae and Homo sapiens. Brief incursions into systems of other organisms have also been achieved when they provide new information.S. cerevisiae and H. sapiens mitochondrial DNA (mtDNA) have been thought for a long time to share closely related architecture and replication mechanisms. However, recent studies suggest that mitochondrial genome of S. cerevisiae may be formed, at least partially, from linear multimeric molecules, while human mtDNA is circular. Although several proteins involved in the replication of these two genomes are very similar, divergences are also now increasingly evident. As an example, the recently cloned human mitochondrial DNA polymerase beta-subunit has no counterpart in yeast. Yet, yeast Abf2p and human mtTFA are probably not as closely functionally related as thought previously. Some mtDNA metabolism factors, like DNA ligases, were until recently largely uncharacterized, and have been found to be derived from alternative nuclear products. Many factors involved in the metabolism of mitochondrial DNA are linked through genetic or biochemical interconnections. These links are presented on a map. Finally, we discuss recent studies suggesting that the yeast mtDNA replication system diverges from that observed in man, and may involve recombination, possibly coupled to alternative replication mechanisms like rolling circle replication." @default.
- W2016308603 created "2016-06-24" @default.
- W2016308603 creator A5003248169 @default.
- W2016308603 creator A5065142541 @default.
- W2016308603 date "2000-04-01" @default.
- W2016308603 modified "2023-09-23" @default.
- W2016308603 title "New features of mitochondrial DNA replication system in yeast and man" @default.
- W2016308603 cites W110338166 @default.
- W2016308603 cites W1485255926 @default.
- W2016308603 cites W1488283633 @default.
- W2016308603 cites W1493605791 @default.
- W2016308603 cites W1495843779 @default.
- W2016308603 cites W151059553 @default.
- W2016308603 cites W154063391 @default.
- W2016308603 cites W1561453626 @default.
- W2016308603 cites W1575382738 @default.
- W2016308603 cites W1597095463 @default.
- W2016308603 cites W1624763535 @default.
- W2016308603 cites W1669999604 @default.
- W2016308603 cites W1683995796 @default.
- W2016308603 cites W1703028909 @default.
- W2016308603 cites W1762691437 @default.
- W2016308603 cites W1773955914 @default.
- W2016308603 cites W179236238 @default.
- W2016308603 cites W183349502 @default.
- W2016308603 cites W1844945199 @default.
- W2016308603 cites W1919533270 @default.
- W2016308603 cites W1964558597 @default.
- W2016308603 cites W1968197570 @default.
- W2016308603 cites W1970381458 @default.
- W2016308603 cites W1971082641 @default.
- W2016308603 cites W1971871399 @default.
- W2016308603 cites W1977666912 @default.
- W2016308603 cites W1980779505 @default.
- W2016308603 cites W1982303848 @default.
- W2016308603 cites W1986869352 @default.
- W2016308603 cites W1987779112 @default.
- W2016308603 cites W1990265147 @default.
- W2016308603 cites W1991008715 @default.
- W2016308603 cites W2001054829 @default.
- W2016308603 cites W2001109729 @default.
- W2016308603 cites W2001256046 @default.
- W2016308603 cites W2001287919 @default.
- W2016308603 cites W2001614456 @default.
- W2016308603 cites W2002662437 @default.
- W2016308603 cites W2004099247 @default.
- W2016308603 cites W2005928903 @default.
- W2016308603 cites W2010236625 @default.
- W2016308603 cites W2011073385 @default.
- W2016308603 cites W2011605550 @default.
- W2016308603 cites W2019789560 @default.
- W2016308603 cites W2020873450 @default.
- W2016308603 cites W2027082776 @default.
- W2016308603 cites W2029212995 @default.
- W2016308603 cites W2032203503 @default.
- W2016308603 cites W2032909431 @default.
- W2016308603 cites W2033464711 @default.
- W2016308603 cites W2033643351 @default.
- W2016308603 cites W2034206561 @default.
- W2016308603 cites W2034699636 @default.
- W2016308603 cites W2041151299 @default.
- W2016308603 cites W2044494908 @default.
- W2016308603 cites W2045067920 @default.
- W2016308603 cites W2047705536 @default.
- W2016308603 cites W2047727890 @default.
- W2016308603 cites W2049033330 @default.
- W2016308603 cites W2050769203 @default.
- W2016308603 cites W2051624260 @default.
- W2016308603 cites W2052760252 @default.
- W2016308603 cites W2055565431 @default.
- W2016308603 cites W2061774182 @default.
- W2016308603 cites W2063618774 @default.
- W2016308603 cites W2070739500 @default.
- W2016308603 cites W2079030916 @default.
- W2016308603 cites W2081223432 @default.
- W2016308603 cites W2096472696 @default.
- W2016308603 cites W2096720596 @default.
- W2016308603 cites W2098246822 @default.
- W2016308603 cites W2104760869 @default.
- W2016308603 cites W2106488157 @default.
- W2016308603 cites W2107273340 @default.
- W2016308603 cites W2109291482 @default.
- W2016308603 cites W2109323414 @default.
- W2016308603 cites W2109555944 @default.
- W2016308603 cites W2113079150 @default.
- W2016308603 cites W2113937812 @default.
- W2016308603 cites W2122874008 @default.
- W2016308603 cites W2127646692 @default.
- W2016308603 cites W2127759388 @default.
- W2016308603 cites W2132584299 @default.
- W2016308603 cites W2133992850 @default.
- W2016308603 cites W2137191431 @default.
- W2016308603 cites W2137434145 @default.
- W2016308603 cites W2138047093 @default.
- W2016308603 cites W2141982041 @default.
- W2016308603 cites W2145220051 @default.
- W2016308603 cites W2147381007 @default.
- W2016308603 cites W2156061481 @default.