FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016308975> ?p ?o ?g. }

• W2016308975 endingPage "108" @default.
• W2016308975 startingPage "104" @default.
• W2016308975 abstract "Formation of senile plaques (SPs) by amyloid β (Aβ) protein is a neuropathological change which characterizes Alzheimer's disease (AD), and Aβ deposition and neuron loss are essential for the pathological cascade of the disease. Although the mechanism of Aβ deposition remains unclear, it has been suggested that clearance of Aβ protein may be impaired in the AD brain. Previous studies demonstrated that microglia were able to remove Aβ by releasing a metalloprotease or by phagocytosis, suggesting that microglia may play an important role in preventing Aβ deposition in the central nervous system (CNS). On the other hand, it was reported that the number of microglia was reduced in osteopetrotic (op/op) toothless mice resulting from the lack of functional macrophage colony-stimulating factor (M-CSF). The present study was thus designed to examine the Aβ deposition and the number of hippocampal neurons in the brain of op/op mice. A number of fibrillar plaques were detected in the cerebral cortex, hippocampus, amygdala and hypothalamus in op/op mice, however, no quantitative evidence of Aβ deposition was observed in normal mice. Moreover, the total number of pyramidal cells in the hippocampal CA1, and CA3 regions was significantly reduced in op/op mice when compared to the controls. These results demonstrate that Aβ deposition influence neuron loss and it may be suspected that expression of SPs may be in part regulated by microglia under physiological conditions." @default.
• W2016308975 created "2016-06-24" @default.
• W2016308975 creator A5002239538 @default.
• W2016308975 creator A5018999606 @default.
• W2016308975 creator A5024171991 @default.
• W2016308975 creator A5034010241 @default.
• W2016308975 creator A5038782195 @default.
• W2016308975 creator A5040661189 @default.
• W2016308975 creator A5066708203 @default.
• W2016308975 creator A5068627527 @default.
• W2016308975 creator A5072576439 @default.
• W2016308975 creator A5080949231 @default.
• W2016308975 date "2003-10-01" @default.
• W2016308975 modified "2023-10-11" @default.
• W2016308975 title "Amyloid β protein deposition and neuron loss in osteopetrotic (op/op) mice" @default.
• W2016308975 cites W1572812739 @default.
• W2016308975 cites W1853196938 @default.
• W2016308975 cites W1980851788 @default.
• W2016308975 cites W1988740119 @default.
• W2016308975 cites W1992598058 @default.
• W2016308975 cites W2001210466 @default.
• W2016308975 cites W2008737860 @default.
• W2016308975 cites W2019759965 @default.
• W2016308975 cites W2026487546 @default.
• W2016308975 cites W2035394884 @default.
• W2016308975 cites W2036288989 @default.
• W2016308975 cites W2041138285 @default.
• W2016308975 cites W2046569445 @default.
• W2016308975 cites W2047930088 @default.
• W2016308975 cites W2059214757 @default.
• W2016308975 cites W2064276266 @default.
• W2016308975 cites W2079096751 @default.
• W2016308975 cites W2081881251 @default.
• W2016308975 cites W2082487815 @default.
• W2016308975 cites W2084883686 @default.
• W2016308975 cites W2108689038 @default.
• W2016308975 cites W2115026640 @default.
• W2016308975 cites W2132382876 @default.
• W2016308975 cites W2142437726 @default.
• W2016308975 cites W2159092116 @default.
• W2016308975 cites W2162298355 @default.
• W2016308975 cites W2162591919 @default.
• W2016308975 cites W2169525835 @default.
• W2016308975 doi "https://doi.org/10.1016/j.brainresprot.2003.09.001" @default.
• W2016308975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14613812" @default.
• W2016308975 hasPublicationYear "2003" @default.
• W2016308975 type Work @default.
• W2016308975 sameAs 2016308975 @default.
• W2016308975 citedByCount "15" @default.
• W2016308975 countsByYear W20163089752012 @default.
• W2016308975 countsByYear W20163089752013 @default.
• W2016308975 countsByYear W20163089752015 @default.
• W2016308975 countsByYear W20163089752021 @default.
• W2016308975 crossrefType "journal-article" @default.
• W2016308975 hasAuthorship W2016308975A5002239538 @default.
• W2016308975 hasAuthorship W2016308975A5018999606 @default.
• W2016308975 hasAuthorship W2016308975A5024171991 @default.
• W2016308975 hasAuthorship W2016308975A5034010241 @default.
• W2016308975 hasAuthorship W2016308975A5038782195 @default.
• W2016308975 hasAuthorship W2016308975A5040661189 @default.
• W2016308975 hasAuthorship W2016308975A5066708203 @default.
• W2016308975 hasAuthorship W2016308975A5068627527 @default.
• W2016308975 hasAuthorship W2016308975A5072576439 @default.
• W2016308975 hasAuthorship W2016308975A5080949231 @default.
• W2016308975 hasConcept C142724271 @default.
• W2016308975 hasConcept C148762608 @default.
• W2016308975 hasConcept C160448771 @default.
• W2016308975 hasConcept C169760540 @default.
• W2016308975 hasConcept C185592680 @default.
• W2016308975 hasConcept C203014093 @default.
• W2016308975 hasConcept C2776914184 @default.
• W2016308975 hasConcept C2777633098 @default.
• W2016308975 hasConcept C2778794669 @default.
• W2016308975 hasConcept C2779134260 @default.
• W2016308975 hasConcept C2779830541 @default.
• W2016308975 hasConcept C2781161787 @default.
• W2016308975 hasConcept C502032728 @default.
• W2016308975 hasConcept C529278444 @default.
• W2016308975 hasConcept C68026918 @default.
• W2016308975 hasConcept C71924100 @default.
• W2016308975 hasConcept C86803240 @default.
• W2016308975 hasConcept C87753298 @default.
• W2016308975 hasConcept C95444343 @default.
• W2016308975 hasConceptScore W2016308975C142724271 @default.
• W2016308975 hasConceptScore W2016308975C148762608 @default.
• W2016308975 hasConceptScore W2016308975C160448771 @default.
• W2016308975 hasConceptScore W2016308975C169760540 @default.
• W2016308975 hasConceptScore W2016308975C185592680 @default.
• W2016308975 hasConceptScore W2016308975C203014093 @default.
• W2016308975 hasConceptScore W2016308975C2776914184 @default.
• W2016308975 hasConceptScore W2016308975C2777633098 @default.
• W2016308975 hasConceptScore W2016308975C2778794669 @default.
• W2016308975 hasConceptScore W2016308975C2779134260 @default.
• W2016308975 hasConceptScore W2016308975C2779830541 @default.
• W2016308975 hasConceptScore W2016308975C2781161787 @default.
• W2016308975 hasConceptScore W2016308975C502032728 @default.
• W2016308975 hasConceptScore W2016308975C529278444 @default.
• W2016308975 hasConceptScore W2016308975C68026918 @default.

• next