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- W2016309560 abstract "The annual incidence of deep venous thrombosis (DVT) is approximately 0.1% in the general population, 1.3% in hospitalized patients, and 1.8% among the elderly between 65 and 69 years old.1,2 Pulmonary embolism (PE) subsequently develops in 25% of individuals, with a 15 to 20% mortality rate.1 There are few data concerning venous thromboembolism in ALS and other neuromuscular disorders. We examined the occurrence of symptomatic DVT in patients with ALS enrolled in the placebo-controlled, double-blind clinical trials of topiramate, creatine, and celecoxib performed by the Northeast ALS (NEALS) Consortium from 1998 to 20043–5 (see table E-1 on the Neurology Web site at www.neurology.org).Seven hundred patients with ALS were enrolled in three studies: 296 in the topiramate trial, 104 in the creatine trial, and 300 in the celecoxib trial. We excluded patients receiving topiramate because 6% of patients given topiramate, vs 1% of patients given placebo, had an episode of DVT or PE.3 The increased incidence …" @default.
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- W2016309560 date "2007-01-02" @default.
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- W2016309560 title "Increased incidence of deep venous thrombosis in ALS" @default.
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- W2016309560 doi "https://doi.org/10.1212/01.wnl.0000250444.30622.ee" @default.
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