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- W2016316911 endingPage "12" @default.
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- W2016316911 abstract "The skin has long been recognized as a major producer of cytokines, but the keratinocyte as principal epidermal cell has received less attention as potential source and target of cytokines. Nevertheless, keratinocytes produce a plethora of cytokines including interleukin (IL)-1, -6, -7, -8, -10, -12, -15, -18, and -20, and tumor necrosis factor α (TNF). The production by keratinocytes of pro-inflammatory (IL)-1, -6, -8, and TNF was recognized early and is well studied. Keratinocyte-derived IL-7 and -15 are considered to be significant in T-cell trafficking, possibly even in the pathogenesis of cutaneous T-cell lymphoma. Immunomodulatory IL-10 and -12 originating from keratinocytes are considered to be responsible for systemic effects, and IL-18 perhaps has a similar action. Keratinocytes were fairly recently recognized as being source or target of other IL-10 family members like IL-20 and IL-24 and the role of these cytokines in specific diseases is under investigation. In addition, a variety of cytokine receptors are present on keratinocytes like those for IL-4, -13, and -17 and to lesser degree IL-2. The ability to study the expression of cytokines by keratinocytes in vivo and in vitro using primary cells, immortalized cells or even organotypic culture systems offers many possibilities to further investigate the role of cytokine production in keratinocyte biology and disease." @default.
- W2016316911 created "2016-06-24" @default.
- W2016316911 creator A5001890172 @default.
- W2016316911 date "2002-09-01" @default.
- W2016316911 modified "2023-10-18" @default.
- W2016316911 title "Keratinocytes and cytokines" @default.
- W2016316911 cites W1505277713 @default.
- W2016316911 cites W1516024856 @default.
- W2016316911 cites W1529895897 @default.
- W2016316911 cites W1533962165 @default.
- W2016316911 cites W1553506096 @default.
- W2016316911 cites W1556474055 @default.
- W2016316911 cites W1558030894 @default.
- W2016316911 cites W1587718614 @default.
- W2016316911 cites W1597342698 @default.
- W2016316911 cites W1607409445 @default.
- W2016316911 cites W1640509666 @default.
- W2016316911 cites W1692495181 @default.
- W2016316911 cites W1785821026 @default.
- W2016316911 cites W182986896 @default.
- W2016316911 cites W1887563241 @default.
- W2016316911 cites W1944006756 @default.
- W2016316911 cites W1963551425 @default.
- W2016316911 cites W1963731011 @default.
- W2016316911 cites W1965000300 @default.
- W2016316911 cites W1965650772 @default.
- W2016316911 cites W1967618658 @default.
- W2016316911 cites W1969077093 @default.
- W2016316911 cites W1969191030 @default.
- W2016316911 cites W1969249757 @default.
- W2016316911 cites W1970396422 @default.
- W2016316911 cites W1970508213 @default.
- W2016316911 cites W1972113581 @default.
- W2016316911 cites W1973217233 @default.
- W2016316911 cites W1973326314 @default.
- W2016316911 cites W1976494868 @default.
- W2016316911 cites W1978573819 @default.
- W2016316911 cites W1981148628 @default.
- W2016316911 cites W1981899137 @default.
- W2016316911 cites W1982996351 @default.
- W2016316911 cites W1983424467 @default.
- W2016316911 cites W1988929299 @default.
- W2016316911 cites W1989001888 @default.
- W2016316911 cites W1993080021 @default.
- W2016316911 cites W1994154093 @default.
- W2016316911 cites W1997319936 @default.
- W2016316911 cites W2003018576 @default.
- W2016316911 cites W2005481350 @default.
- W2016316911 cites W2005581733 @default.
- W2016316911 cites W2005779622 @default.
- W2016316911 cites W2006960282 @default.
- W2016316911 cites W2007896079 @default.
- W2016316911 cites W2008444492 @default.
- W2016316911 cites W2015213556 @default.
- W2016316911 cites W2015232905 @default.
- W2016316911 cites W2015569311 @default.
- W2016316911 cites W2016471878 @default.
- W2016316911 cites W2017482803 @default.
- W2016316911 cites W2019083095 @default.
- W2016316911 cites W2019288826 @default.
- W2016316911 cites W2020483508 @default.
- W2016316911 cites W2020740955 @default.
- W2016316911 cites W2021081081 @default.
- W2016316911 cites W2023471949 @default.
- W2016316911 cites W2023614210 @default.
- W2016316911 cites W2024847290 @default.
- W2016316911 cites W2025780723 @default.
- W2016316911 cites W2028408635 @default.
- W2016316911 cites W2033987263 @default.
- W2016316911 cites W2036792358 @default.
- W2016316911 cites W2039433021 @default.
- W2016316911 cites W2042253739 @default.
- W2016316911 cites W2043773693 @default.
- W2016316911 cites W2045448061 @default.
- W2016316911 cites W2047010940 @default.
- W2016316911 cites W2047144606 @default.
- W2016316911 cites W2048482120 @default.
- W2016316911 cites W2050042205 @default.
- W2016316911 cites W2051399616 @default.
- W2016316911 cites W2051508620 @default.
- W2016316911 cites W2054293096 @default.
- W2016316911 cites W2054401625 @default.
- W2016316911 cites W2059032249 @default.
- W2016316911 cites W2059107640 @default.
- W2016316911 cites W2064346797 @default.
- W2016316911 cites W2065045458 @default.
- W2016316911 cites W2065184397 @default.
- W2016316911 cites W2065550897 @default.
- W2016316911 cites W2071765648 @default.
- W2016316911 cites W2078054905 @default.
- W2016316911 cites W2083370113 @default.
- W2016316911 cites W2085564777 @default.
- W2016316911 cites W2086268791 @default.
- W2016316911 cites W2089024013 @default.
- W2016316911 cites W2091237142 @default.
- W2016316911 cites W2092891157 @default.
- W2016316911 cites W2096379150 @default.
- W2016316911 cites W2101060955 @default.