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• W2016317526 endingPage "2035" @default.
• W2016317526 startingPage "2024" @default.
• W2016317526 abstract "More than 20 years of research on heme as a temporary effector molecule of proteins have revealed its widespread impact on virtually all primary functions in the human organism. As our understanding of this influence is still growing, a comprehensive overview of compiled data will give fresh impetus for creativity and developing new strategies in heme-related research. From known data concerning heme-regulated proteins and their involvement in the development of diseases, we provide concise information of FeII/III heme as a regulator and the availability of “regulatory heme”. The latter is dependent on the balance between free and bound FeII/III heme, here termed “hemeostasis”. Imbalance of this system can lead to the development of diseases that were not always attributed to this small molecule. Diseases such as cancer or Alzheimer's disease highlight the reawakened interest in heme, whose function was previously believed to be completely understood." @default.
• W2016317526 created "2016-06-24" @default.
• W2016317526 creator A5048467037 @default.
• W2016317526 creator A5060630266 @default.
• W2016317526 date "2014-09-04" @default.
• W2016317526 modified "2023-10-01" @default.
• W2016317526 title "Regulatory Fe^II/IIIHeme: The Reconstruction of a Molecule's Biography" @default.
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