Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016329114> ?p ?o ?g. }
- W2016329114 endingPage "2918" @default.
- W2016329114 startingPage "2910" @default.
- W2016329114 abstract "The mechanisms associated with the immunostimulatory activity of vaccine adjuvants are still poorly understood. We have undertaken a study to determine whether antigen-presenting cell trafficking is modified by administration of the submicron emulsion adjuvant MF59. We investigated the fate of inflammatory macrophages after intramuscular injection of the antigen herpes simplex virus gD2 with fluorescence-labeled MF59. A homogenous population of macrophages infiltrated the muscle, internalized adjuvant and expressed markers characteristic of mature macrophages over a 48-h period. Macrophage influx to the injection site was reduced by 70% in mice deficient for the chemokine receptor 2 (CCR2). Two distinct cell populations were shown to contain fluorescence-labeled MF59 in the draining lymph node at 48 h post injection. The first population had a round morphology, exhibited bright fluorescence, was located in the subcapsular sinus, and was apoptotic. The second population had a dendritic morphology, was weakly fluorescent, and was located in the T cell area where adjuvant-containing apoptotic bodies identified by TUNEL labeling were present. We propose that lymph node-resident dendritic cells can acquire antigen and MF59 after intramuscular immunization by uptake of the apoptotic macrophages." @default.
- W2016329114 created "2016-06-24" @default.
- W2016329114 creator A5000331823 @default.
- W2016329114 creator A5003202268 @default.
- W2016329114 creator A5003462092 @default.
- W2016329114 creator A5034129769 @default.
- W2016329114 creator A5055939902 @default.
- W2016329114 creator A5078199027 @default.
- W2016329114 creator A5091032090 @default.
- W2016329114 date "2001-10-01" @default.
- W2016329114 modified "2023-10-13" @default.
- W2016329114 title "Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosis" @default.
- W2016329114 cites W107174851 @default.
- W2016329114 cites W1561591381 @default.
- W2016329114 cites W1572881837 @default.
- W2016329114 cites W1577698383 @default.
- W2016329114 cites W1600424468 @default.
- W2016329114 cites W1603541349 @default.
- W2016329114 cites W1665455704 @default.
- W2016329114 cites W1895115148 @default.
- W2016329114 cites W1901597074 @default.
- W2016329114 cites W1979132095 @default.
- W2016329114 cites W1986497597 @default.
- W2016329114 cites W1990223878 @default.
- W2016329114 cites W1990258307 @default.
- W2016329114 cites W1996537376 @default.
- W2016329114 cites W1996661642 @default.
- W2016329114 cites W2002956679 @default.
- W2016329114 cites W2004722629 @default.
- W2016329114 cites W2005047889 @default.
- W2016329114 cites W2011801328 @default.
- W2016329114 cites W2013872507 @default.
- W2016329114 cites W2015954946 @default.
- W2016329114 cites W2028527058 @default.
- W2016329114 cites W2053849689 @default.
- W2016329114 cites W2064899848 @default.
- W2016329114 cites W2072137194 @default.
- W2016329114 cites W2077654197 @default.
- W2016329114 cites W2083055420 @default.
- W2016329114 cites W2088024377 @default.
- W2016329114 cites W2091140484 @default.
- W2016329114 cites W2100446366 @default.
- W2016329114 cites W2102857621 @default.
- W2016329114 cites W2103147774 @default.
- W2016329114 cites W2111220263 @default.
- W2016329114 cites W2121290793 @default.
- W2016329114 cites W2122814661 @default.
- W2016329114 cites W2123076394 @default.
- W2016329114 cites W2131761283 @default.
- W2016329114 cites W2156555210 @default.
- W2016329114 cites W2158500407 @default.
- W2016329114 cites W2161669288 @default.
- W2016329114 cites W2163183562 @default.
- W2016329114 cites W2166876123 @default.
- W2016329114 cites W2173652987 @default.
- W2016329114 cites W2203497969 @default.
- W2016329114 cites W2340524139 @default.
- W2016329114 cites W4211264883 @default.
- W2016329114 doi "https://doi.org/10.1002/1521-4141(2001010)31:10<2910::aid-immu2910>3.0.co;2-3" @default.
- W2016329114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11592066" @default.
- W2016329114 hasPublicationYear "2001" @default.
- W2016329114 type Work @default.
- W2016329114 sameAs 2016329114 @default.
- W2016329114 citedByCount "126" @default.
- W2016329114 countsByYear W20163291142012 @default.
- W2016329114 countsByYear W20163291142013 @default.
- W2016329114 countsByYear W20163291142014 @default.
- W2016329114 countsByYear W20163291142015 @default.
- W2016329114 countsByYear W20163291142016 @default.
- W2016329114 countsByYear W20163291142017 @default.
- W2016329114 countsByYear W20163291142018 @default.
- W2016329114 countsByYear W20163291142019 @default.
- W2016329114 countsByYear W20163291142021 @default.
- W2016329114 countsByYear W20163291142022 @default.
- W2016329114 countsByYear W20163291142023 @default.
- W2016329114 crossrefType "journal-article" @default.
- W2016329114 hasAuthorship W2016329114A5000331823 @default.
- W2016329114 hasAuthorship W2016329114A5003202268 @default.
- W2016329114 hasAuthorship W2016329114A5003462092 @default.
- W2016329114 hasAuthorship W2016329114A5034129769 @default.
- W2016329114 hasAuthorship W2016329114A5055939902 @default.
- W2016329114 hasAuthorship W2016329114A5078199027 @default.
- W2016329114 hasAuthorship W2016329114A5091032090 @default.
- W2016329114 hasBestOaLocation W20163291141 @default.
- W2016329114 hasConcept C147483822 @default.
- W2016329114 hasConcept C153911025 @default.
- W2016329114 hasConcept C202751555 @default.
- W2016329114 hasConcept C203014093 @default.
- W2016329114 hasConcept C2777863537 @default.
- W2016329114 hasConcept C2779244956 @default.
- W2016329114 hasConcept C2780849966 @default.
- W2016329114 hasConcept C2908647359 @default.
- W2016329114 hasConcept C502942594 @default.
- W2016329114 hasConcept C55493867 @default.
- W2016329114 hasConcept C71924100 @default.
- W2016329114 hasConcept C86803240 @default.
- W2016329114 hasConcept C95444343 @default.
- W2016329114 hasConcept C99454951 @default.