FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016331441> ?p ?o ?g. }

• W2016331441 endingPage "235" @default.
• W2016331441 startingPage "226" @default.
• W2016331441 abstract "The tat gene is required by HIV-1 for efficient reverse transcription and this function of Tat can be distinguished from its role in transcription by RNA polymerase II using tat point mutations that abrogate each function independently. The mechanism of Tat's role in reverse transcription, however, is not known, nor is it known whether this role is conserved among trans-activating factors in other retroviruses. Here we examine the abilities of heterologous viral trans-activating proteins from jembrana disease virus (jTat), HIV-2 (Tat2), and equine infectious anemia virus (eTat) to substitute for HIV-1 Tat (Tat1) and restore reverse transcription in HIV-1 carrying an inactivated tat gene. Natural endogenous reverse transcription assays showed that trans-activators from some retroviruses (Tat2 and jTat, but not eTat) could substitute for Tat1 in complementation of HIV-1 reverse transcription. Finally, we show that Y47 is critical for Tat1 to function in reverse transcription, but not HIV-1 gene expression. We mutated the homologous position in jTat to H62Y and found it did not improve its ability to stimulate reverse transcription, but an H62A mutation did inhibit jTat complementation. These data highlight the finding that the role of Tat in reverse transcription is not related to trans-activation and demonstrate that other tat genes conserve this function." @default.
• W2016331441 created "2016-06-24" @default.
• W2016331441 creator A5017279608 @default.
• W2016331441 creator A5063613499 @default.
• W2016331441 creator A5069433396 @default.
• W2016331441 creator A5070910151 @default.
• W2016331441 creator A5082606672 @default.
• W2016331441 date "2002-09-01" @default.
• W2016331441 modified "2023-09-30" @default.
• W2016331441 title "Human Immunodeficiency Virus Type 1 Reverse Transcription Is Stimulated by Tat from Other Lentiviruses" @default.
• W2016331441 cites W1495312602 @default.
• W2016331441 cites W1505598199 @default.
• W2016331441 cites W1530265254 @default.
• W2016331441 cites W1788807811 @default.
• W2016331441 cites W1905921278 @default.
• W2016331441 cites W1973851039 @default.
• W2016331441 cites W1984882587 @default.
• W2016331441 cites W1993095717 @default.
• W2016331441 cites W1997356859 @default.
• W2016331441 cites W201050536 @default.
• W2016331441 cites W2013241878 @default.
• W2016331441 cites W2019064263 @default.
• W2016331441 cites W2051989796 @default.
• W2016331441 cites W2064853121 @default.
• W2016331441 cites W2069278922 @default.
• W2016331441 cites W2069869908 @default.
• W2016331441 cites W2076100163 @default.
• W2016331441 cites W2089449840 @default.
• W2016331441 cites W2125318771 @default.
• W2016331441 cites W2143661142 @default.
• W2016331441 cites W2143783087 @default.
• W2016331441 cites W2160557659 @default.
• W2016331441 cites W2162875989 @default.
• W2016331441 cites W2166597417 @default.
• W2016331441 cites W2166761820 @default.
• W2016331441 cites W2258770630 @default.
• W2016331441 doi "https://doi.org/10.1006/viro.2002.1554" @default.
• W2016331441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12350353" @default.
• W2016331441 hasPublicationYear "2002" @default.
• W2016331441 type Work @default.
• W2016331441 sameAs 2016331441 @default.
• W2016331441 citedByCount "10" @default.
• W2016331441 countsByYear W20163314412013 @default.
• W2016331441 countsByYear W20163314412014 @default.
• W2016331441 countsByYear W20163314412015 @default.
• W2016331441 countsByYear W20163314412018 @default.
• W2016331441 countsByYear W20163314412019 @default.
• W2016331441 crossrefType "journal-article" @default.
• W2016331441 hasAuthorship W2016331441A5017279608 @default.
• W2016331441 hasAuthorship W2016331441A5063613499 @default.
• W2016331441 hasAuthorship W2016331441A5069433396 @default.
• W2016331441 hasAuthorship W2016331441A5070910151 @default.
• W2016331441 hasAuthorship W2016331441A5082606672 @default.
• W2016331441 hasBestOaLocation W20163314411 @default.
• W2016331441 hasConcept C101762097 @default.
• W2016331441 hasConcept C104317684 @default.
• W2016331441 hasConcept C138885662 @default.
• W2016331441 hasConcept C143065580 @default.
• W2016331441 hasConcept C144825837 @default.
• W2016331441 hasConcept C146027311 @default.
• W2016331441 hasConcept C150194340 @default.
• W2016331441 hasConcept C153911025 @default.
• W2016331441 hasConcept C156719811 @default.
• W2016331441 hasConcept C159047783 @default.
• W2016331441 hasConcept C179926584 @default.
• W2016331441 hasConcept C188082640 @default.
• W2016331441 hasConcept C2780115692 @default.
• W2016331441 hasConcept C41895202 @default.
• W2016331441 hasConcept C54355233 @default.
• W2016331441 hasConcept C64350747 @default.
• W2016331441 hasConcept C67705224 @default.
• W2016331441 hasConcept C86339819 @default.
• W2016331441 hasConcept C86803240 @default.
• W2016331441 hasConceptScore W2016331441C101762097 @default.
• W2016331441 hasConceptScore W2016331441C104317684 @default.
• W2016331441 hasConceptScore W2016331441C138885662 @default.
• W2016331441 hasConceptScore W2016331441C143065580 @default.
• W2016331441 hasConceptScore W2016331441C144825837 @default.
• W2016331441 hasConceptScore W2016331441C146027311 @default.
• W2016331441 hasConceptScore W2016331441C150194340 @default.
• W2016331441 hasConceptScore W2016331441C153911025 @default.
• W2016331441 hasConceptScore W2016331441C156719811 @default.
• W2016331441 hasConceptScore W2016331441C159047783 @default.
• W2016331441 hasConceptScore W2016331441C179926584 @default.
• W2016331441 hasConceptScore W2016331441C188082640 @default.
• W2016331441 hasConceptScore W2016331441C2780115692 @default.
• W2016331441 hasConceptScore W2016331441C41895202 @default.
• W2016331441 hasConceptScore W2016331441C54355233 @default.
• W2016331441 hasConceptScore W2016331441C64350747 @default.
• W2016331441 hasConceptScore W2016331441C67705224 @default.
• W2016331441 hasConceptScore W2016331441C86339819 @default.
• W2016331441 hasConceptScore W2016331441C86803240 @default.
• W2016331441 hasIssue "2" @default.
• W2016331441 hasLocation W20163314411 @default.
• W2016331441 hasLocation W20163314412 @default.
• W2016331441 hasOpenAccess W2016331441 @default.
• W2016331441 hasPrimaryLocation W20163314411 @default.
• W2016331441 hasRelatedWork W1982726429 @default.

• next