Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016331919> ?p ?o ?g. }
- W2016331919 endingPage "789" @default.
- W2016331919 startingPage "783" @default.
- W2016331919 abstract "Inhibition of masculine copulatory behavior was previously demonstrated following systemic injections of hydroxyflutamide (OHF). In the present study, we examined the localization of the effects of this androgen receptor blocker by direct intracranial implantation of OHF into the medial preoptic area (MPOA), ventromedial nucleus of hypothalamus (VMN), medial amygdala (AME), and lateral septum (SEPT). Animals were implanted intracranially with crystalline OHF or cholesterol, and at the same time received two 10-mm testosterone-filled Silastic capsules SC. Tests for restoration of copulatory behavior were initiated 3 days later, and conducted twice weekly for 2 weeks. Implants of OHF into the MPOA were effective in preventing restoration of male sexual behavior. However, the most effective site was the VMN. Implants of OHF into the AME were only partially effective in stimulating male sexual behavior, whereas implants into the SEPT had no effect. The OHF was discontinued and 1 week later males were retested for sexual behavior. The majority of these animals ejaculated, indicating that the effects of OHF are reversible. The results of this study demonstrate that the functional integrity of androgen receptors in some, but not all, androgen-concentrating brain loci is necessary for the expression of the complete pattern of male sexual behavior. These data lend support to the view that androgen receptor populations in specific brain loci differentially express proteins involved in mediating the masculine copulatory response." @default.
- W2016331919 created "2016-06-24" @default.
- W2016331919 creator A5000462706 @default.
- W2016331919 creator A5004381678 @default.
- W2016331919 creator A5048672351 @default.
- W2016331919 date "1996-09-01" @default.
- W2016331919 modified "2023-10-14" @default.
- W2016331919 title "Inhibition of male sex behavior by androgen receptor blockade in preoptic area or hypothalamus, but not amygdala or septum" @default.
- W2016331919 cites W1977515663 @default.
- W2016331919 cites W1987226988 @default.
- W2016331919 cites W1987630753 @default.
- W2016331919 cites W1989064357 @default.
- W2016331919 cites W1997814801 @default.
- W2016331919 cites W1998196987 @default.
- W2016331919 cites W1998689277 @default.
- W2016331919 cites W1999629808 @default.
- W2016331919 cites W2007414241 @default.
- W2016331919 cites W2024117628 @default.
- W2016331919 cites W2029623655 @default.
- W2016331919 cites W2032642878 @default.
- W2016331919 cites W2038811111 @default.
- W2016331919 cites W2043392919 @default.
- W2016331919 cites W2059054885 @default.
- W2016331919 cites W2059297425 @default.
- W2016331919 cites W2060462002 @default.
- W2016331919 cites W2067648763 @default.
- W2016331919 cites W2070781517 @default.
- W2016331919 cites W2071319145 @default.
- W2016331919 cites W2079615173 @default.
- W2016331919 cites W2080778811 @default.
- W2016331919 cites W2083022526 @default.
- W2016331919 cites W2087062933 @default.
- W2016331919 cites W2087119152 @default.
- W2016331919 cites W2093797475 @default.
- W2016331919 cites W2107413237 @default.
- W2016331919 cites W2120380130 @default.
- W2016331919 cites W2121917893 @default.
- W2016331919 cites W2135397106 @default.
- W2016331919 doi "https://doi.org/10.1016/0031-9384(96)00088-1" @default.
- W2016331919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8873251" @default.
- W2016331919 hasPublicationYear "1996" @default.
- W2016331919 type Work @default.
- W2016331919 sameAs 2016331919 @default.
- W2016331919 citedByCount "88" @default.
- W2016331919 countsByYear W20163319192012 @default.
- W2016331919 countsByYear W20163319192013 @default.
- W2016331919 countsByYear W20163319192014 @default.
- W2016331919 countsByYear W20163319192015 @default.
- W2016331919 countsByYear W20163319192017 @default.
- W2016331919 countsByYear W20163319192018 @default.
- W2016331919 countsByYear W20163319192019 @default.
- W2016331919 countsByYear W20163319192020 @default.
- W2016331919 countsByYear W20163319192021 @default.
- W2016331919 countsByYear W20163319192022 @default.
- W2016331919 crossrefType "journal-article" @default.
- W2016331919 hasAuthorship W2016331919A5000462706 @default.
- W2016331919 hasAuthorship W2016331919A5004381678 @default.
- W2016331919 hasAuthorship W2016331919A5048672351 @default.
- W2016331919 hasConcept C121608353 @default.
- W2016331919 hasConcept C126322002 @default.
- W2016331919 hasConcept C134018914 @default.
- W2016331919 hasConcept C15744967 @default.
- W2016331919 hasConcept C2776046087 @default.
- W2016331919 hasConcept C2776451244 @default.
- W2016331919 hasConcept C2777003273 @default.
- W2016331919 hasConcept C2777911890 @default.
- W2016331919 hasConcept C2778652331 @default.
- W2016331919 hasConcept C2779144063 @default.
- W2016331919 hasConcept C2779279991 @default.
- W2016331919 hasConcept C2780192828 @default.
- W2016331919 hasConcept C61367390 @default.
- W2016331919 hasConcept C71315377 @default.
- W2016331919 hasConcept C71924100 @default.
- W2016331919 hasConcept C86803240 @default.
- W2016331919 hasConceptScore W2016331919C121608353 @default.
- W2016331919 hasConceptScore W2016331919C126322002 @default.
- W2016331919 hasConceptScore W2016331919C134018914 @default.
- W2016331919 hasConceptScore W2016331919C15744967 @default.
- W2016331919 hasConceptScore W2016331919C2776046087 @default.
- W2016331919 hasConceptScore W2016331919C2776451244 @default.
- W2016331919 hasConceptScore W2016331919C2777003273 @default.
- W2016331919 hasConceptScore W2016331919C2777911890 @default.
- W2016331919 hasConceptScore W2016331919C2778652331 @default.
- W2016331919 hasConceptScore W2016331919C2779144063 @default.
- W2016331919 hasConceptScore W2016331919C2779279991 @default.
- W2016331919 hasConceptScore W2016331919C2780192828 @default.
- W2016331919 hasConceptScore W2016331919C61367390 @default.
- W2016331919 hasConceptScore W2016331919C71315377 @default.
- W2016331919 hasConceptScore W2016331919C71924100 @default.
- W2016331919 hasConceptScore W2016331919C86803240 @default.
- W2016331919 hasIssue "3" @default.
- W2016331919 hasLocation W20163319191 @default.
- W2016331919 hasLocation W20163319192 @default.
- W2016331919 hasOpenAccess W2016331919 @default.
- W2016331919 hasPrimaryLocation W20163319191 @default.
- W2016331919 hasRelatedWork W1976078643 @default.
- W2016331919 hasRelatedWork W2004033001 @default.
- W2016331919 hasRelatedWork W2062244832 @default.