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- W2016332326 abstract "Understanding the potential toxicities of manufactured nanoconstructs used for drug delivery and biomedical applications may help improve their safety. We sought to determine if surface-modified silica nanoparticles and poly(amido amine) dendrimers elicit genotoxic responses on vascular endothelial cells. The nanoconstructs utilized in this study had a distinct geometry (spheres vs worms) and surface charge, which were used to evaluate the contributions of these parameters to any potential adverse effects of these materials. Time-dependent cytotoxicity was found for surfaced-functionalized but geometrically distinct silica materials, while amine-terminated dendrimers displayed time-independent cytotoxicity and carboxylated dendrimers were nontoxic in our assays. Transcriptomic evaluation of human aortic endothelial cell (HAEC) responses indicated time-dependent gene induction following silica exposure, consisting of cell cycle gene repression and pro-inflammatory gene induction. However, the dendrimers did not induce genomic toxicity, despite displaying general cytotoxicity." @default.
- W2016332326 created "2016-06-24" @default.
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- W2016332326 date "2013-07-10" @default.
- W2016332326 modified "2023-09-27" @default.
- W2016332326 title "Transcriptional Responses of Human Aortic Endothelial Cells to Nanoconstructs Used in Biomedical Applications" @default.
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- W2016332326 doi "https://doi.org/10.1021/mp400285u" @default.
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