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- W2016333855 abstract "The effect of ethanol exposure in vitro on the GABA receptor-operated chloride channel was evaluated by monitoring 36Cl− influx in a membrane vesicle suspension (microsacs) prepared from mouse cerebellum. These experiments directly demonstrate ethanol augmentation of muscimol-stimulated chloride flux. DBA/2J mice were made tolerant to and dependent on ethanol by administration of an ethanol containing liquid diet for 7 days. Exposure to physiologically relevant concentrations of ethanol (10–45 mM) in vitro potentiated muscimol stimulation of 36Cl− uptake in control (pair-fed) membranes, but had no effect on cerebellar microsacs from tolerant/dependent mice. Muscimol stimulation of 36Cl− uptake was not different for pair-fed and ethanol-treated mice. Augmentation of muscimol-induced 36Cl− flux by in vitro ethanol was abolished by a single 4 g/kg injection of ethanol. This “acute tolerance” occurred within 5 min and disappeared within 24 hr after ethanol treatment. The reduced sensitivity of ethanol treated (chronic and acute) mice to ethanol potentiation of muscimol stimulated 36Cl− uptake offers a biochemical correlate to the phenomenon of ethanol tolerance. Moreover, the findings suggest that this biochemical tolerance develops rapidly following a single hypnotic dose of ethanol." @default.
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- W2016333855 title "Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels" @default.
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- W2016333855 doi "https://doi.org/10.1016/0091-3057(87)90192-4" @default.
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